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Detection of fetal cells present in transcervical samples

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  15 January 2010

Matteo Adinolfi
Matteo Adinolfi*
Affiliation:
Department of Obstetrics and Gynaecology and Galton Laboratory, University College London, London.
*
Professor Matteo Adinolfi, The Galton Laboratory, Department of Genetics and Biometry, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE.
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Extract

In 1971 Shettles postulated that, during pregnancy, chorionic cellular elements from degenerating villi were shed into the endocervical canal and could be analysed to assess fetal sex. Accordingly, he retrieved transcervical cells (TCC's) with cotton swabs and tested them for the presence of the Y chromosome using a fluorescent dye (quinacrine mustard). At the time of publishing his note, he had correctly diagnosed the sex of 10 fetuses in 18 pregnancies investigated.

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 8 , Issue 1 , February 1996 , pp. 1 - 10
Copyright
Copyright © Cambridge University Press 1996

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References

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