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The role of calcium channel blockers in the treatment of women with preeclampsia

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  15 January 2010

R Lewis ,
M Belfort  and
B Sibai
R Lewis
Affiliation:
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Tennessee, Memphis, Tennessee.
M Belfort
Affiliation:
Department of Obstetrics & Gynecology and Anesthesiology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, Texas.
B Sibai*
Affiliation:
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Tennessee, Memphis, Tennessee.
*
Baha Sibai, MD, Department of Obstetrics and Gynecology, 853 Jefferson Ave., Rm E-102, Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103.
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Extract

Preeclampsia was originally known as a process whereby an unknown “toxin” was responsible for a variety of responses. While this toxin has yet to be determined, many theories have prevailed as to the appropriate therapy for this condition.

Recently, antihypertensive therapy has become increasingly regarded as an important component of the medical management of women with preeclampsia. Initially, the ideal therapy for peripartum acute hypertensive emergencies was felt to be a smooth muscle relaxant and the most commonly prescribed agent was hydralazine. This drug was felt to be beneficial because of its action on vascular smooth muscle, decreasing vasospasm. Outside of the United States diazoxide was also used for this purpose, although this drug has been replaced because of the high incidence of fetal distress. Another agent that was frequently used was α-methyldopa which was initially considered to be the treatment of choice in the treatment of patieats with moderate and severe preeclampsia. Recently, α-methyldopa has been reserved for the outpatient management of gestational hypertension, especially in women with mild preeclampsia or chronic hypertension.

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 8 , Issue 1 , February 1996 , pp. 19 - 27
Copyright
Copyright © Cambridge University Press 1996

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