Skip to main content

A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice

  • Mary F. Lyon (a1) and P. H. Glenister (a1)

A mutation to an apparently new allele at the W-locus of the mouse arose spontaneously in a cross between two inbred strains. Heterozygotes have a broad white sash, leading to the name and symbol sash, Wsh. Homozygotes are black-eyed whites which are viable, fertile and not anaemic, although the gene does cause mild haematopoietic defects. The original mutant animal also carried a spontaneous recessive lethal mutation on chromosome 5, mapping at 2 cM distal to the W-locus.

Hide All
Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441454.
Evans, E. P. & Phillips, R. J. S. (1975). Inversion heterozygosity and the origin of XO daughters of Bpa/ + female mice. Nature 256, 4041.
Geissler, E. N., McFarland, E. C. & Russell, E. S. (1981). Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: A description of ten new W alleles. Genetics 97, 337361.
Guenet, J.-L., Marchal, G., Milon, G., Tambourin, P. & Wendlino, F. (1979). Fertile dominant spotting (Wf): A new allele at the W locus. Journal of Heredity 70, 912.
Haldane, J. B. S. (1936). The amount of heterozygosis to be expected in an approximately pure line. Journal of Genetics 32, 375391.
Loutit, J. F., Corp, M. J. & Adams, P. J. V. (1982). Radiosensitivity of mice with mutation at loci W, Ph. International Journal of Radiation Biology (in press).
Loutit, J. F., Peters, J. & Stevens, J. (1981). Spleen colony forming cell as common precursor for tissue mast cells and granulocytes. Nature 294, 290.
McLaren, A. (1976). Genetics of the early mouse embryo. Annual Review of Genetics 10, 361388.
Russell, E. S. (1979). Hereditary anaemias of the mouse: a review for geneticists. Advances in Genetics 20, 357459.
Schlager, G. & Dickie, M. M. (1971). Natural mutation rates in the house mouse: estimates for five specific loci and dominant mutations. Mutation Research 11, 8996.
Sherman, M. I. & Wudl, L. R. (1977). T-complex mutations and their effects. In Concepts in Mammalian Embryogenesis (ed. Sherman, M. I.), pp. 136234. Cambridge, Mass.: MIT Press.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed