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A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 ORD, U.K.
P. H. Glenister
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 ORD, U.K.
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A mutation to an apparently new allele at the W-locus of the mouse arose spontaneously in a cross between two inbred strains. Heterozygotes have a broad white sash, leading to the name and symbol sash, Wsh. Homozygotes are black-eyed whites which are viable, fertile and not anaemic, although the gene does cause mild haematopoietic defects. The original mutant animal also carried a spontaneous recessive lethal mutation on chromosome 5, mapping at 2 cM distal to the W-locus.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

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A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice
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