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Antagonism between novobiocin and coumermycin A1 in Bacillus subtilis

Published online by Cambridge University Press:  14 April 2009

István Gadó ,
Valéria Széll ,
Kálmán Büki  and
György Szvoboda
István Gadó
Affiliation:
Institute for Drug Research, Budapest, Hungary;
Valéria Széll
Affiliation:
Institute for Drug Research, Budapest, Hungary;
Kálmán Büki
Affiliation:
Second Institute of Biochemistry, Semmelweis University Medical School, Budapest, Hungary
György Szvoboda
Affiliation:
Institute for Drug Research, Budapest, Hungary;

Summary

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When combinations of inhibitors acting on the subunit B of DNA gyrase were tested in Bac. subtilis strains, the growth-inhibiting effect of novobiocin was specifically antagonized by subinhibitory concentrations of coumermycin A1. An antagonism in the opposite direction was not observed.

Two alternative models are proposed, where the supercoiling decrease caused by novobiocin is antagonized by coumermycin.

This phenomenon seems to be characteristic of the Bac. subtilis species.

Type
Research Article
Information
Genetics Research , Volume 44 , Issue 3 , December 1984 , pp. 243 - 250
Copyright
Copyright © Cambridge University Press 1984

References

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