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Controlling elements in the mouse: IV. Evidence of non-random X-inactivation

Published online by Cambridge University Press:  14 April 2009

P. G. Johnston
Affiliation:
School of Biological Sciences, Macquarie University, North Ryde, New South Wales 2113, Australia
B. M. Cattanach
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Oxon 0X11 ORD, U.K.
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Summary

The non-random X chromosome expression that has been observed with coat markers in female mice heterozygous for the Xce alleles, Xcea and Xceb, has now been investigated with the electrophoretic enzyme marker, Pgk-1. Because the Xce status of the Pgk-1a marked chromosome was not known, PGK expression was assessed in Pgk-1a/Pgk-lb heterozygotes which carried either Xcea or Xceb on their Pgk-1b chromosome. The PGK-1A allozyme was found to predominate in both genotypes but when Xceb was present on the Pgk-lb chromosome the expression of the two allo-zymes was less unequal. This effect was seen in both liver and kidney of adults and to at least the same degree in embryos aged 13·5 and 7·5 days. The results have been interpreted to mean that the non-random X expression derives from a primary non-randomness of the X inactivation process and that a new and more extreme Xce allele, designated Xcec, was present on the Pgr-1a-marked X chromosome.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1981

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