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A correction to the exact test based on the Ewens sampling distribution

  • Montgomery Slatkin (a1)

Summary

The exact test for neutrality based on the Ewens sampling distribution described previously (Slatkin, 1994) is not correct. The problem is that the test as described is based on the probability of the ordered configuration of numbers of alleles, while it should be based on the probability of the unordered configuration. The correctly implemented exact test leads to results that are similar to those from the homozygosity test proposed by Watterson (1977) for relatively small sample sizes but can still differ substantially for larger sample sizes. Programs to perform the exact test are available from the author.

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Copyright

References

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Ewens, W. J., (1972). The sampling theory of selectively neutral alleles. Theoretical Population Biology 3, 87112.
Ewens, W. J., (1979). Mathematical Population Genetics. Berlin: Springer.
Keith, T. P., Brooks, L. D., Lewontin, R. C., Martinez-Cruzado, J. C., & Rigby, D. L., (1985). Nearly identical distributions of xanthine dehydrogenase in two populations of Drosophila pseudoobscura. Molecular Biology and Evolution 2, 206216.
Slatkin, M., (1994). An exact test for neutrality based on the Ewens sampling distribution. Genetical Research 64, 7174.
Stewart, F. M., (1977). Computer algorithm for obtaining a random set of allele frequencies for a locus in an equilibrium population. Genetics 86, 482483.
Watterson, G. A., (1977). Heterosis or neutrality? Genetics 85, 789814.

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