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Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon  and
Kathleen B. Bechtol
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Harwell, Oxon
Kathleen B. Bechtol
Affiliation:
Department of Zoology, South Parks Road, Oxford, England
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The genetic properties of some new mutant t-haplotypes derived from the naturally occurring haplotype t6 have been investigated. Several mutant haplotypes gave taillessness with brachyury, T, were viable when homozygous, and when in compound with t6, and all these expressed tf and appeared to have arisen by meiotic crossing-over between T and tf in the region of crossover-suppression of t6. The haplotype th17 arose by crossing-over in a stock of t6 carrying the translocation T(1; 17) 190Ca, in which the translocation break in chromosome 17 is within the crossover-suppressing region; hence th17 could not be separated from T190. It was of the complementary crossover type in that it did not interact with T, and was lethal in compound with t6; its male segregation ratio was normal with heterogeneity. A further haplotype, th20, expressed tf, gave taillessness with T, and was lethal when homozygous and in compound with t6. The expression of tf was attributed to a deletion, which also covered the loci of the nearby lethals knobbly, Kb, and tw5. th20 showed weak complementation of tw5. The haplotype th7 had previously been interpreted as carrying a duplication; it was shown that this duplication was semi-lethal when homozygous. it is suggested that lethal mutant t-haplotypes commonly arise by duplication or deletion but such structural changes are not necessarily at the end of the haplotype, and need not arise by unequal meiotic crossing-over.

Information

Type
Research Article
Information
Genetics Research , Volume 30 , Issue 1 , August 1977 , pp. 63 - 76
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Bechtol, K. & Lyon, M. F. (1977) (in preparation).Google Scholar
Bennett, D. (1975). The t-locus of the mouse. Cell 6. 441–454.CrossRefGoogle Scholar
Bennett, D. & Dunn, L. C. (1964). Repeated occurrences in the mouse of lethal alleles of the same complementation group. Genetics 49. 949–958.CrossRefGoogle ScholarPubMed
Bennett, D., Dunn, L. C. & Badenhausen, S. (1959). A second group of similar lethals in populations of wild house mice. Genetics 44. 795–802.Google Scholar
Bennett, D., Dunn, L. C. & Artzt, K. (1976). Genetic change in mutations at the T/t-locus in the mouse. Genetics 83. 361–372.CrossRefGoogle Scholar
Carter, T. C. & Phillips, R. J. S. (1950). Three recurrences of mutants in the house mouse. Journal of Heredity 41, 252.CrossRefGoogle ScholarPubMed
Carter, T. C., Lyon, M. F. & Phillips, R. J. S. (1955). Gene-tagged chromosome translocations in eleven stocks of mice. Journal of Genetics 53. 154–166.Google Scholar
Carter, T. C.Lyon, M. F. & Phillips, R. J. S. (1956). Further genetic studies of eleven translocations in the mouse. Journal of Genetics 54. 462–473.CrossRefGoogle Scholar
Dunn, L. C. (1960). Variations in the transmission ratios of alleles through egg and sperm in Mus musculus. American Naturalist 94. 385–393.CrossRefGoogle Scholar
Dunn, L. C., Bennett, D. & Beasley, A. B. (1962). Mutation and recombination in the vicinity of a complex gene. Genetics 47. 285–303.CrossRefGoogle ScholarPubMed
Hammerberg, C. & Klein, J. (1975 a) Linkage disequilibrium between H-2 and t complexes in chromosome 17 of the mouse. Nature 258. 296–299.CrossRefGoogle Scholar
Hammerberg, C. & Klein, J. (1975 b). Linkage relationships of markers on chromosome 17 of the house mouse. Genetical Research 26. 203–211.CrossRefGoogle ScholarPubMed
Klein, J. (1975). Biology of the Mouse Histocompatibility-2 Complex. Berlin: Springer Verlag.CrossRefGoogle Scholar
Klein, J. & Hammerberg, C. (1977). The control of differentiation by the T complex. Immunological Reviews 33. 70–104.CrossRefGoogle ScholarPubMed
Klein, J. & Klein, D. (1972). Position of the translocation break T(2;9)138Ca in linkage group IX of the mouse. Genetical Research 19. 177–179.Google Scholar
Lyon, M. F. (1967). Private communication. Mouse News Letter 36, 35.Google Scholar
Lyon, M. F. & Mason, I. (1977). Information on the nature of t-haplotypes from the interaction of mutant haplotypes in male fertility and segregation ratio. Genetical Research (in the Press).CrossRefGoogle Scholar
Lyon, M. F. & Meredith, R. (1964 a) The nature of t-alleles in the mouse. I. Genetic analysis of a series of mutants derived from a lethal allele. Heredity 19. 301–312.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Meredith, R. (1964 b). The nature of t-alleles in the mouse. II. Genetic analysis of an unusual mutant allele and its derivatives. Heredity 19. 313–325.Google Scholar
Lyon, M. F. & Meredith, R. (1964 c) The nature of t-alleles in the mouse. III. Short tests of some further mutant alleles. Heredity 19. 327–330.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Phillips, R. J. S. (1959). Crossing-over in mice heterozygous for t-alleles. Heredity 13. 23–32.CrossRefGoogle Scholar
Silagi, S. (1962). A genetical and embryological study of partial complementation between lethal alleles at the T locus of the house mouse. Developmental Biology 5. 35–67.CrossRefGoogle Scholar