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Estimating the recombination parameter of a finite population model without selection

  • Richard R. Hudson (a1)

Summary

An estimator is proposed for the parameter C = 4Nc. where N is the population size and c is the recombination rate. The estimator is appropriate for use with sequence or restriction site data from random samples from within populations. Properties of the estimator are investigated for an infinite-sites neutral model using Monte Carlo simulations. The median and mode of the distribution of the estimator are close to the true value for all parameter values examined, but large data sets are required to obtain reliable estimates.

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References

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Brown, A. H. D., Feldman, M. W. & Nevo, E. (1980). Multilocus structure of natural populations of Hordeum spontaneum. Genetics 96, 523536.
Chakraborty, R. (1984). Detection of nonrandom association of alleles from the distribution of the number of heterozygous loci in a sample. Genetics 108, 719731.
Chakraborty, R. (1981). The distribution of the number of heterozygous loci in an individual in natural populations. Genetics 98, 461466.
Chakravarti, A., Buetow, K. H., Antonarakis, S. E., Waber, P. G., Boehm, C. D. & Kazazian, H. H. (1984). Nonuniform recombination within the human β-globin gene cluster. American Journal of Human Genetics 36, 12391258.
Chovnick, A., Gelbart, W. & McCarron, M. (1977). Organization of the Rosy locus in Drosophila melanogaster. Cell 11, 110.
Ewens, W. J. (1979). Mathematical Population Genetics. New York: Springer-Verlag.
Hill, W. G. (1981). Estimation of effective population size from data on linkage disequilibrium. Genetical Research 38, 209216.
Hudson, R. R. (1983). Properties of a neutral allele model with intragenic recombination. Theoretical Population Biology 23, 183201.
Hudson, R. R. (1985). The sampling distribution of linkage disequilibrium under an infinite allele model without selection. Genetics 109, 611631.
Hudson, R. R. & Kaplan, N. L. (1985). Statistical properties of the number of recombination events in the history of a sample of DNA sequences. Genetics 111, 147164.
Hudson, R. R., Kreitman, M. & Aguadé, M. (1987). A test of neutral molecular evolution based on nucleotide data. Genetics 116, 153159
Kreitman, M. (1983). Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster. Nature 304, 412417.
Kreitman, M. & Aguadé, M. (1986 a). Genetic uniformity in two populations of Drosophila melanogaster as revealed by filter hydridization of four-nucleotide-recognizing restriction enzyme digests. Proceedings of the National Academcy of Sciences, USA 83, 35623566.
Kreitman, M. & Aguadé, M. (1986 b). Excess polymorphism at the Adh locus in Drosophila melanogaster. Genetics 114, 93110.
Langley, C. H. (1977). Nonrandom associations between allozymes in natural populations of Drosophila melanogaster. In Lecture Notes in Biomathematics, 19, Measuring Selection in Natural Populations (ed. Christiansen, F. B. and Fenchell, T. M.), pp. 265273. New York: Springer-Verlag.
Laurie-Ahlberg, C. & Weir, B. S. (1979). Allozyme variation and linkage disequilibrium in some laboratory populations of Drosophila melanogaster. Genetics 92, 12951314.
Li, W.-H., Luo, C.-C. & Wu, C.-I. (1985). Evolution of DNA sequences, in Molecular Evolutionary Genetics (ed. Maclntyre, R. J.). New York: Plenum
Ohta, T. (1980). Linkage disequilibrium between amino acid sites in immunoglobulin genes and other multigene families. Genetical Research 36, 181197.
Strobeck, C. & Morgan, K. (1978). The effect of intragenic recombination on the number of alleles in a finite population. Genetics 88, 829844.
Sved, J. A. (1968). The stability of linked systems of loci with small population size. Genetics 59, 543563.
Tajima, F. (1983). Evolutionary relationships of DNA sequences in finite populations. Genetics 105, 437460.
Weir, B. S. & Hill, W. G. (1980). Effect of mating structure on variation in linkage disequilibrium. Genetics 95, 477488.
Weir, B. S. & Hill, W. G. (1986). Nonuniform recombination within the human β-globin gene cluster. American Journal of Human Genetics 38, 776778.

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