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Estimating the recombination parameter of a finite population model without selection

  • Richard R. Hudson (a1)
Abstract
Summary

An estimator is proposed for the parameter C = 4Nc. where N is the population size and c is the recombination rate. The estimator is appropriate for use with sequence or restriction site data from random samples from within populations. Properties of the estimator are investigated for an infinite-sites neutral model using Monte Carlo simulations. The median and mode of the distribution of the estimator are close to the true value for all parameter values examined, but large data sets are required to obtain reliable estimates.

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A. Chovnick , W. Gelbart & M. McCarron (1977). Organization of the Rosy locus in Drosophila melanogaster. Cell 11, 110.

R. R. Hudson (1983). Properties of a neutral allele model with intragenic recombination. Theoretical Population Biology 23, 183201.

M. Kreitman (1983). Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster. Nature 304, 412417.

M. Kreitman & M. Aguadé (1986 a). Genetic uniformity in two populations of Drosophila melanogaster as revealed by filter hydridization of four-nucleotide-recognizing restriction enzyme digests. Proceedings of the National Academcy of Sciences, USA83, 35623566.

C. H. Langley (1977). Nonrandom associations between allozymes in natural populations of Drosophila melanogaster. In Lecture Notes in Biomathematics, 19, Measuring Selection in Natural Populations (ed. F. B. Christiansen and T. M. Fenchell ), pp. 265273. New York: Springer-Verlag.

W.-H. Li , C.-C. Luo & C.-I. Wu (1985). Evolution of DNA sequences, in Molecular Evolutionary Genetics (ed. R. J. Maclntyre ). New York: Plenum

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Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
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