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Estimation of effective population size from data on linkage disequilibrium1

  • William G. Hill (a1)
  • DOI:
  • Published online: 01 April 2009

A method is proposed for estimating effective population size (N) from data on linkage disequilibrium among neutral genes at several polymorphic loci or restriction sites. The efficiency of the method increases with larger sample size and more tightly linked genes; but for very tightly linked genes estimates of N are more dependent on long-term than on recent population history. Two sets of data are analysed as examples.

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W. G. Hill (1974). Estimation of linkage disequilibrium in randomly mating populations. Heredity 33, 229239.

W. G. Hill (1976). Non-random association of neutral linked genes in finite populations. In Population Genetics and Ecology (ed. S. Karlin and E. Nevo ), pp. 339376. New York: Academic Press.

W. G. Hill (1977). Correlation of gene frequencies between neutral linked genes in finite populations. Theoretical Population Biology 11, 239248.

W. G. Hill & A. Robertson (1968). Linkage disequilibrium in finite populations. Theoretical and Applied Genetics 38, 226231.

Y. W. Kan & A. M. Dozy (1978). Polymorphism of DNA sequence adjacent to human β-globulin structural gene: relationship to sickle mutation. Proceedings of the National Academy of Sciences of USA 75, 56315635.

C. H. Langley (1977). Nonrandom associations between allozymes in natural populations of Drosophila melanogaster. In Lecture Notes in Biomathematics. 19. Measuring Selection in Natural Populations (ed. F. B. Christiansen and T. M. Fenchel ), pp. 265273. New York: Springer-Verlag.

J. A. Sved & M. W. Feldman (1973). Correlation and probability methods for one and two loci. Theoretical Population Biology 4, 129132.

B. S. Weir (1979). Inferences about linkage disequilibrium. Biometrics 35, 235254.

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Genetics Research
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