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Estimation of microsatellite mutation rates in Drosophila melanogaster

  • JOSÉ FERNANDO VÁZQUEZ (a1), TRINIDAD PÉREZ (a1), JESÚS ALBORNOZ (a1) and ANA DOMÍNGUEZ (a1)

Abstract

Microsatellite mutations were studied in a set of 175 mutation accumulation lines, all of them independently derived from a completely homozygous population of Drosophila melanogaster and maintained under strong inbreeding during 80 generations. We assayed 28 microsatellites and detected two mutations. One mutation consisted of a single addition of a dinucleotide repeat and the other was a deletion of five trinucleotide repeats. The average mutation rate was 5·1 × 10−6, in full agreement with previous estimates from two different sets of mutation accumulation lines.

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Corresponding author

Corresponding author. e-mail: ads@sauron.quimica.uniovi.es
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Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
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