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Genetic loads at a polymorphic locus which is maintained by frequency-dependent selection*

Published online by Cambridge University Press:  14 April 2009

Motoo Kimura  and
Tomoko Ohta
Motoo Kimura
Affiliation:
National Institute of Genetics, Mishima, Japan
Tomoko Ohta
Affiliation:
National Institute of Genetics, Mishima, Japan
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Summary

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If a polymorphic locus is maintained in finite populations by frequency-dependent selection with selective neutrality at equilibrium, it is generally accompanied by two genetic loads, i.e. the dysmetric and the drift loads. The former arises because the fitness of the population may not be at a maximum at the equilibrium gene frequency and the latter because genetic drift in small populations displaces the gene frequency from its equilibrium value.

In some simple models of frequency-dependent selection considered, the drift load is independent of selection coefficients and is approximately equal to (n−1)/(2Ne), where n is the number of alleles and Ne is the effective population size.

Information

Type
Research Article
Information
Genetics Research , Volume 16 , Issue 2 , October 1970 , pp. 145 - 150
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Clarke, B. & O'Donald, P. (1964). Frequency-dependent selection. Heredity 19, 201–206.CrossRefGoogle Scholar
Haldane, J. B. S. (1954). The statics of evolution. In Evolution as a Process (Ed. Huxley, J. et al. ), pp. 109–121. London: George Allen and Unwin.Google Scholar
Kojima, K. & Yarbrough, K. M. (1967). Frequency-dependent selection at the esterase 6 locus in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America, 57, 645–649.CrossRefGoogle ScholarPubMed
Robertson, A. (1970). The reduction of fitness from genetic drift at heterotic loci in small populations. Genetical Research 15, 257–260.CrossRefGoogle ScholarPubMed
Wright, S. (1949). Adaptation and selection. In Genetics, Paleontology and Evolution (Ed. Jepsen, G. et al. ), pp. 365–389. Princeton: Princeton University Press.Google Scholar
Wright, S. & Dobzhansky, Th. (1946). Genetics of natural populations. XII. Experimental reproduction of some of the changes caused by natural selection in certain populations of Drosophila pseudoobscura. Genetics 31, 125–156.CrossRefGoogle Scholar