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A lethal mutation (cab) affecting heart function in the mouse

Published online by Cambridge University Press:  14 April 2009

Francine B. Essien
Francine B. Essien
Affiliation:
Department of Biological Sciences, Douglass College, Rutgers University, New Brunswick, New Jersey 80903
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Summary

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A new autosomal recessive gene (cab, ‘cardiac abnormality’), which affects heart differentiation appeared spontaneously in our mouse colony. The affected homozygotes die approximately half a day prior to birth or at term, with the myocardium exhibiting vacuolation and large areas of mesenchyme-like cells. A significant finding in mutant foetuses is the lack of histochemically detectable glycogen.

Type
Research Article
Information
Genetics Research , Volume 33 , Issue 1 , February 1979 , pp. 57 - 59
Copyright
Copyright © Cambridge University Press 1979

References

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