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Linkage mapping of sex-specific differences

Published online by Cambridge University Press:  02 April 2002

RONGLING WU ,
CHANG-XING MA ,
S. S. WU  and
ZHAO-BANG ZENG
RONGLING WU
Affiliation:
Department of Statistics, University of Florida, Gainesville, FL 32611 USA
CHANG-XING MA
Affiliation:
Department of Statistics, University of Florida, Gainesville, FL 32611 USA Department of Statistics, Nankai University, Tianjin 300071, China
S. S. WU
Affiliation:
Department of Statistics, University of Florida, Gainesville, FL 32611 USA
ZHAO-BANG ZENG
Affiliation:
Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
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Abstract

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Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based on sex-specific linkage maps.

Type
Research Article
Information
Genetics Research , Volume 79 , Issue 1 , February 2002 , pp. 85 - 96
Copyright
© 2002 Cambridge University Press