Hostname: page-component-76c49bb84f-rx8cm Total loading time: 0 Render date: 2025-07-08T07:12:14.718Z Has data issue: false hasContentIssue false
  • English
  • Français

A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population*

Published online by Cambridge University Press:  14 April 2009

Tomoko Ohta  and
Motoo Kimura
Tomoko Ohta
Affiliation:
National Institute of Genetics, Mishima, Japan
Motoo Kimura
Affiliation:
National Institute of Genetics, Mishima, Japan
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A new model of mutational production of alleles was proposed which may be appropriate to estimate the number of electrophoretically detectable alleles maintained in a finite population. The model assumes that the entire allelic states are expressed by integers (…, A−1, A0, A1, …) and that if an allele changes state by mutation the change occurs in such a way that it moves either one step in the positive direction or one step in the negative direction (see also Fig. 1). It was shown that for this model the ‘effective’ number of selectively neutral alleles maintained in a population of the effective size Ne under mutation rate υ per generation is given by

When 4Neυ is small, this differs little from the conventional formula by Kimura & Crow, i.e. ne = 1 + 4Neυ, but it gives a much smaller estimate than this when 4Neυ is large.

Information

Type
Short Papers
Information
Genetics Research , Volume 22 , Issue 2 , October 1973 , pp. 201 - 204
Copyright
Copyright © Cambridge University Press 1973

References

REFERENCES

Ayala, F. J., Powell, J. R., Tracey, M. L., Moubão, C. A. & Pébez-Salas, S. (1972). Enzyme variability in the Drosophila willistoni group. IV. Genetic variation in natural populations of Drosophila willistoni. Genetics 70, 113–139.CrossRefGoogle ScholarPubMed
Henning, U. & Yanofsky, C. (1963). An electrophoretic study of mutationally altered A proteins of the tryptophan synthetase of Escherichia coli. J. Molecular Biology 6, 16–21.CrossRefGoogle ScholarPubMed
Kimura, M. & Crow, J. F. (1964). The number of alleles that can be maintained in a finite population. Genetics 49, 725–738.CrossRefGoogle Scholar
Kimura, M. & Ohta, T. (1971). Protein polymorphism as a phase of molecular evolution. Nature 229, 467–469.CrossRefGoogle ScholarPubMed
Ohta, T. & Kimura, M. (1971). Linkage disequilibrium between two segregating nucleotide sites under the steady flux of mutations in a finite population. Genetics 68, 571–580.CrossRefGoogle Scholar