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Probability of identical monomorphism in related species

  • Masatoshi Nei (a1) and Wen-Hsiung Li (a1)
  • DOI:
  • Published online: 01 April 2009

A mathematical method for evaluating the probability that a locus is monomorphic for the same allele in related species is developed under the neutral mutation hypothesis. A formula for the proportion of identically monomorphic loci in related species is also worked out. The results of the application of this method to Drosophila data do not support Prakash & Lewontin's (1968) contention that the strong association between gene arrangements (inversion chromosomes) and alleles at protein loci is evidence of coadaptation of genes in the inverted segment of chromosomes. Similarly, unlike Haigh & Maynard Smith's (1972) contention, the monomorphism of the haemoglobin α chain locus in man can be accommodated with the neutral mutation hypothesis without invoking the bottleneck effect.

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Genetics Research
  • ISSN: 0016-6723
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