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Recombinational analysis of the viable t-haplotype t38

Published online by Cambridge University Press:  14 April 2009

Dorothea Bennett ,
Karen Artzt ,
Janice Cookingham  and
Catherine Calo
Dorothea Bennett
Affiliation:
Laboratory of Developmental Genetics, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, U.S.A.
Karen Artzt
Affiliation:
Laboratory of Developmental Genetics, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, U.S.A.
Janice Cookingham
Affiliation:
Laboratory of Developmental Genetics, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, U.S.A.
Catherine Calo
Affiliation:
Laboratory of Developmental Genetics, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, U.S.A.
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Summary

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A viable t-haplotype, t38, has been shown to distort linkage relations in the T−tf region of mouse chromosome 17. Separate experiments were done with two different interstitial markers, Low and qk, which map respectively about 5 and 4 centimorgans (cM) from the locus of T in female T + tf/ + (Low or qk)+ heterozygotes. In females that carried t38, however (i.e. t38+ + / + Low tf or t38+ + / + qk tf), there was virtually no recombination between t38 and either interstitial marker, although the t38−tf distance was normal. These observations suggest that t38 suppresses recombination in the lefthand part of that region and strongly enhances it further to the right.

Information

Type
Research Article
Information
Genetics Research , Volume 33 , Issue 3 , June 1979 , pp. 269 - 277
Copyright
Copyright © Cambridge University Press 1979

References

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