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Screening of guinea pig strains for electrophoretic isoenzyme polymorphisms

Published online by Cambridge University Press:  14 April 2009

F. Csaikl
F. Csaikl
Affiliation:
Institute of Tumorbiology-Cancer Research of the University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria
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Summary

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Seven strains of guinea pig (Cavia porcellus) with different degrees of inbreeding were investigated for genetic variability by starch gel electrophoresis. Variants for six out of 31 loci (Gpd-1, Aat-1, Ak-2, Pgm-1, Ada and Gpi) are reported. The data suggest that the strains all come from a small founding population and therefore are genetically more homogenous than the visible characteristics imply. Differences between isoenzyme data and other genetic characters are described and possible underlying genetic mechanisms are discussed.

Type
Research Article
Information
Genetics Research , Volume 47 , Issue 1 , February 1986 , pp. 53 - 57
Copyright
Copyright © Cambridge University Press 1986

References

Altman, P. L. & Katz, D. D. (1979). Inbred and Genetically Defined Strains of Laboratory Animals. Part 2. Bethesda, Maryland. Hamster, Guinea Pig, Rabbit and Chicken. Federation of American Societies for Experimental Biology.Google Scholar
Ayala, F. J. (1976). Molecular Evolution. Sunderland, Mass: Sinauer Ass., Inc.Google Scholar
Bacon, L. D., Rose, N. R., Lisah, R. P. & de Week, A. L. (1979). Immune reactions and immunological diseases: guinea pig. In Inbred and Genetically Defined Strains of Laboratory Animals. Part 2 (ed. Altman, P. L. and Katz, D. D.). Bethesda, Maryland: Hamster, Guinea Pig, Rabbit and Chicken. FASEB.Google Scholar
Bender, K. & Günther, E. (1977). Screening of inbred rat strains for electrophoretic protein polymorphisms. Biochemical Genetics 16, 387.CrossRefGoogle Scholar
Carter, N. D. (1972). Carbonic anhydrase in Cavia aperea, Cavia porcellus and their hybrids. Comparative Biochemistry and Physiology B 43, 743.Google ScholarPubMed
Carter, N. D. & Festing, M. F. W. (1972). Erythrocyte enzyme and protein variation in three guinea-pig strains. Guinea-Pig Newsletter 6, 12.Google Scholar
Carter, N. D., Hill, M. R. & Weir, B. J. (1972). Genetic variation of phosphoglucose isomerase in some hystrichomorph rodents. Biochemical Genetics 63, 147.CrossRefGoogle Scholar
Csaikl, F. (1984). Electrophoretic comparison of Syrian and Chinese hamster species. Heredity 52, 141.CrossRefGoogle ScholarPubMed
Csaikl, F., Engel, W. & Schmidtke, J. (1980). On the biochemical systematics of three Apodemus species. Comparative Biochemistry and Physiology 65 B, 411.Google Scholar
Engel, W., Schmidtke, J. & Wolf, U. (1971). Genetic variation of α-glycerophosphate dehydrogenase isoenzymes in clupeoid and salmonoid fish. Experientia 27, 1489.CrossRefGoogle ScholarPubMed
Frick, L. (1983). An electrophoretic and immunological reinvestigation of the cytosolic di- and tri-peptidases of the guinea pig. Journal of Experimental Zoology 226, 379.CrossRefGoogle Scholar
Harris, H. (1980). The Principles of Human Biochemical Genetics. Amsterdam: North-Holland.Google Scholar
Harris, H. & Hopkinson, D. A. (1976). Handbook of Enzyme Electrophoresis in Human Genetics. Amsterdam: North-Holland.Google Scholar
Hopkinson, D. A., Peters, J. & Harris, H. (1974). Rare electrophoretic variants of glycerol-3-phosphate dehydro-genase: evidence for two structural gene loci (GPD1 and GPD2). Annales of Human Genetics 37, 477.CrossRefGoogle Scholar
Kömpf, J., Ritter, H. & Schmitt, J. (1971). Genetic polymorphism of glycerol-3-phosphate dehydrogenase (E.C. 1.1.1.8). I. Transspecific variability of G-3-PD subunit B in primates. Humangenetik 13, 75.CrossRefGoogle ScholarPubMed
Kömpf, J., Ritter, H. & Schmitt, J. (1972). Genetic polymorphism of glycerol-3-phosphate dehydrogenase (E.C. 1.1.1.8). II. Transpecific variability of G-3-PD subunit A in primates. Formal genetics and population genetics. Humangenetik 14, 103.CrossRefGoogle Scholar
Kozak, L. P. (1972). Genetic control of α-glycerolphosphate dehydrogenase in mouse brain. Proceedings of the National Academy of Sciences, USA 69, 3170.Google Scholar
Kozak, L. P. & Erdelsky, K. J. (1975). The genetics and development regulation of L-glycerol 3-phosphate dehydrogenase. Journal of Cellular Physiology 85, 437.CrossRefGoogle ScholarPubMed
Lyon, M. (1977). Genetic nomenclature and nomenclatorial rules in the mouse. Immunogenetics 5, 393.Google Scholar
Nei, M. (1975). Molecular Population Genetics and Evolution. Amsterdam: North-Holland.Google Scholar
Searle, A. G. (1968). Comparative Genetics of Coat Colour in Mammals. New York: Academic Press.Google Scholar
Staats, J. (1980). Standardized nomenclature for inbred strains of mice: seventh listing. Cancer Research 40, 2083.Google ScholarPubMed
Whang-Peng, J., Lee, E. & Hubbell, H. R. (1979). Karyology: guinea pig. In Inbred and Genetically Defined Strains of Laboratory Animals, Part 2 (ed. Altman, P. L. and Katz, D. D.). Bethesda, Maryland: Hamsters, Guinea Pig, Rabbit and Chicken. FASEB.Google Scholar
Wagner, J. E. & Manning, P. J. (1976). The Biology of the Guinea Pig. New York: Academic Press.Google Scholar
Wright, S. (1963). Genie interaction. In Methodology in Mammalian Genetics, (ed. Burdelle, W. J.). San Francisco, California: Holden-Day.Google Scholar
Wriston, J. C. (1981). Biochemical peculiarities of the guinea pig and some possible examples of convergent evolutions. Journal of Molecular Evolution 17, 1.CrossRefGoogle Scholar
Wriston, J. C. (1984). Comparative biochemistry of the guinea pig: a partial checklist. Comparative Biochemistry and Physiology 77B, 253.Google Scholar