Skip to main content Accessibility help
×
Home

Selection against harmful mutations in large sexual and asexual populations

  • Alexey S. Kondrashov (a1)

Summary

Selection against harmful mutations in large populations is studied assuming that the rate of fitness decrease grows with every new mutation added to a genome. Under this reasonable assumption (Mayr, 1970) the average fitness of a sexual population, without linkage between the loci, is higher, and the average equilibrium number of harmful mutations per individual lower, than in an asexual population. If a gamete contains on the average one or more new mutations, the resulting advantage of sexual reproduction and recombination seems to be sufficient to counterbalance the double advantage of parthenogenesis. Moreover, selection against harmful mutations is probably the most powerful factor preventing linkage disequilibrium even with epistatic interaction between the loci.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Selection against harmful mutations in large sexual and asexual populations
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Selection against harmful mutations in large sexual and asexual populations
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Selection against harmful mutations in large sexual and asexual populations
      Available formats
      ×

Copyright

References

Hide All
Clegg, M. T., Kidwell, J. F. & Horch, C. R. (1980). Dynamics of correlated genetic systems. V. Rates of decay of linkage disequilibria in experimental population of Drosophila melanogaster. Genetics 94, 217234.
Feldman, M. W., Christiansen, F. B. & Brooks, L. D. (1980). Evolution of recombination in constant environment. Proceedings of the National Academy of Sciences of the USA 77, 48384841.
Kimura, M. & Crow, J. F. (1979). Efficiency of truncation selection. Proceedings of the National Academy of Sciences of the USA 76, 396399.
Leslie, J. F. & Vrijenhoek, R. C. (1978). Genetic dissection of clonally inherited genomes of Poecilopsis. I. Linkage analysis and preliminary assessment of deleterious gene loads. Genetics 90, 801811.
Li, W.-H., Gojobori, T. & Nei, M. (1981). Pseudogenes as a paradigm of neutral evolution. Nature 292, 82378239.
Loukas, M., Vegrini, Y. & Krimbas, C. B. (1981). The genetics of Drosophila subobscura populations. XVII. Further genie heterogeneity within electromorphs by urea denaturation and the effect of the increased genie variability on linkage disequilibrium studies. Genetics 97, 429441.
Maynard Smith, J. (1978). The Evolution of Sex. Cambridge University Press.
Maynard Smith, J. (1980). Selection for recombination in a polygenic model. Genetical Research 35, 269278.
Mayr, E. (1970). Populations, species and evolution. Harvard University Press, Cambridge, Mass.
Mukai, T., Chigusa, S. T., Mettler, L. E. & Crow, J. F. (1972). Mutation rate and dominance of genes affecting viability in Drosophila melanogaster. Genetics 72, 335355.
Muller, H. J. (1964). The relation of recombination to mutational advance. Mutation Research 1, 29.

Selection against harmful mutations in large sexual and asexual populations

  • Alexey S. Kondrashov (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed