Skip to main content
×
Home
    • Aa
    • Aa

Selection for recombination in a polygenic model – the mechanism

  • J. Maynard Smith (a1)
Summary
Summary

A polygenic model has been simulated in order to reveal the process whereby selection in an infinite population can lead to an increase in the frequency of alleles causing higher rates of recombination (CH alleles). Directional selection generates repulsion linkage disequilibrium (+ − + −), which is less strong in CH gametes (gametes carrying CH alleles). In consequence, CH gametes contribute greater phenotypic variability, and therefore respond more to directional selection: that is, they accumulate more selectively favoured alleles. CH alleles then increase in frequency by hitch-hiking. In contrast, normalizing selection, or frequent changes in the direction of selection, favour alleles for a low recombination rate.

Copyright
References
Hide All
Bell G. & Maynard Smith J. (1987). Short-term selection for recombination among mutually antagonistic species. Nature 327, 6668.
Bulmer M. G. (1980). The Mathematical Theory of Quantitative Genetics. Oxford: Clarendon Press.
Burt A. & Bell G. (1987). Mammalian chiasma frequencies as a test of two theories of recombination. Nature 326, 803805.
Charlesworth B. (1976). Recombination modification in a fluctuating environment. Genetics 83, 181195.
Felsenstein J. (1965). The effect of linkage on directional selection. Genetics 52, 349363.
Fraser A. S. (1957). Simulation of genetic systems by automatic digital computers. II. Effects of linkage on rates of advance under selection. Australian Journal of Biological Science 10, 492499.
Maynard Smith J. (1980). Selection for recombination in a polygenic model. Genetical Research 35, 269277.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 13 *
Loading metrics...

Abstract views

Total abstract views: 48 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 20th October 2017. This data will be updated every 24 hours.