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Sex differences in fitness and selection for centric fusions between sex-chromosomes and autosomes

  • D. Charlesworth (a1) and B. Charlesworth (a1)

Summary

A model of centric fusions between the X or Y chromosome and an autosome carrying a selected locus is studied. It is assumed that fusions are not associated with any fitness effects, and that all chromosomes disjoin regularly from their homologues. It is shown that a necessary condition for the fusion to be favoured is that there is a selectively maintained sex difference in allele frequencies at the selected locus. If this condition is satisfied, the initial rate of increase of a rare Y-autosome fusion is about three times that of an X-autosome fusion, with the same parameter values. Computer calculations of the final equilibrium states reached by populations containing such fusions were done.

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Copyright

References

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Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
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