Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 36
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Coates, Brad S 2015. Horizontal transfer of a non-autonomous Helitron among insect and viral genomes. BMC Genomics, Vol. 16, Issue. 1, p. 137.

    Charlesworth, Brian and Campos, José L. 2014. The Relations Between Recombination Rate and Patterns of Molecular Variation and Evolution inDrosophila. Annual Review of Genetics, Vol. 48, Issue. 1, p. 383.

    Gallach, M. 2014. Recurrent Turnover of Chromosome-Specific Satellites in Drosophila. Genome Biology and Evolution, Vol. 6, Issue. 6, p. 1279.

    Guerreiro, M P García 2012. What makes transposable elements move in the Drosophila genome?. Heredity, Vol. 108, Issue. 5, p. 461.

    Thomas, Cristel G. Woodruff, Gavin C. and Haag, Eric S. 2012. Causes and consequences of the evolution of reproductive mode in Caenorhabditis nematodes. Trends in Genetics, Vol. 28, Issue. 5, p. 213.

    García Guerreiro, María and Fontdevila, Antonio 2011. Osvaldo and Isis retrotransposons as markers of the Drosophila buzzatii colonisation in Australia. BMC Evolutionary Biology, Vol. 11, Issue. 1, p. 111.

    Granzotto, Adriana Lopes, Fabrício R. Vieira, Cristina and Carareto, Claudia M. A. 2011. Vertical inheritance and bursts of transposition have shaped the evolution of the BS non-LTR retrotransposon in Drosophila. Molecular Genetics and Genomics, Vol. 286, Issue. 1, p. 57.

    Petrov, D. A. Fiston-Lavier, A.-S. Lipatov, M. Lenkov, K. and Gonzalez, J. 2011. Population Genomics of Transposable Elements in Drosophila melanogaster. Molecular Biology and Evolution, Vol. 28, Issue. 5, p. 1633.

    Yurchenko, N. N. Kovalenko, L. V. and Zakharov, I. K. 2011. Transposable elements: Instability of genes and genomes. Russian Journal of Genetics: Applied Research, Vol. 1, Issue. 6, p. 489.

    Schaack, S. Pritham, E. J. Wolf, A. and Lynch, M. 2010. DNA transposon dynamics in populations of Daphnia pulex with and without sex. Proceedings of the Royal Society B: Biological Sciences, Vol. 277, Issue. 1692, p. 2381.

    González, Josefa and Petrov, Dmitri A. 2009. The adaptive role of transposable elements in the Drosophila genome. Gene, Vol. 448, Issue. 2, p. 124.

    Carr, Martin Nelson, Michaela Leadbeater, Barry S.C. and Baldauf, Sandra L. 2008. Three Families of LTR Retrotransposons are Present in the Genome of the Choanoflagellate Monosiga brevicollis. Protist, Vol. 159, Issue. 4, p. 579.

    Subramanian, Ramanand A. Akala, Olabiyi O. Adejinmi, Johnson O. and O'Brochta, David A. 2008. Topi, an IS630/Tc1/mariner-type transposable element in the African malaria mosquito, Anopheles gambiae. Gene, Vol. 423, Issue. 1, p. 63.

    Takahashi, K. H. Tanaka, K. Itoh, M. and Takano-Shimizu, T. 2008. Reduced X-Linked Rare Polymorphism in Males in Comparison to Females of Drosophila melanogaster. Journal of Heredity, Vol. 100, Issue. 1, p. 97.

    Bergman, C. M. and Bensasson, D. 2007. Recent LTR retrotransposon insertion contrasts with waves of non-LTR insertion since speciation in Drosophila melanogaster. Proceedings of the National Academy of Sciences, Vol. 104, Issue. 27, p. 11340.

    Song, Mingzhou and Boissinot, Stéphane 2007. Selection against LINE-1 retrotransposons results principally from their ability to mediate ectopic recombination. Gene, Vol. 390, Issue. 1-2, p. 206.

    TAM, S. M. CAUSSE, M. GARCHERY, C. BURCK, H. MHIRI, C. and GRANDBASTIEN, M.-A. 2007. The distribution of copia-type retrotransposons and the evolutionary history of tomato and related wild species. Journal of Evolutionary Biology, Vol. 20, Issue. 3, p. 1056.

    Casals, Ferran González, Josefa and Ruiz, Alfredo 2006. Abundance and chromosomal distribution of six Drosophila buzzatii transposons: BuT1, BuT2, BuT3, BuT4, BuT5, and BuT6. Chromosoma, Vol. 115, Issue. 5, p. 403.

    O’Brochta, David A. Subramanian, Ramanand A. Orsetti, Jamison Peckham, Edward Nolan, Nicole Arensburger, Peter Atkinson, Peter W. and Charlwood, Derek J. 2006. hAT element population genetics in Anopheles gambiae s.l. in Mozambique. Genetica, Vol. 127, Issue. 1-3, p. 185.

    Jurka, J. Kohany, O. Pavlicek, A. Kapitonov, V.V. and Jurka, M.V. 2005. Clustering, duplication and chromosomal distribution of mouse SINE retrotransposons. Cytogenetic and Genome Research, Vol. 110, Issue. 1-4, p. 117.


The distribution of transposable elements within and between chromosomes in a population of Drosophila melanogaster. II. Inferences on the nature of selection against elements

  • Brian Charlesworth (a1), Angela Lapid (a1) and Darlene Canada (a1)
  • DOI:
  • Published online: 01 April 2009

Data were collected on the distribution of nine families of transposable elements among a sample of autosomes isolated from a natural population of Drosophila melanogaster, by means of in situ hybridization of biotinylated probes to polytene chromosomes. There is no general tendency for elements to accumulate at the tips of chromosomes. Elements tend to be present in excess of random expectation in the euchromatin proximal to the centromeres of the major autosomes, and on chromosome four. There is considerable heterogeneity between different families in the extent of this excess. The overall abundance of element families is inversely related to the extent to which they accumulate proximally. The level of proximal accumulation for the major autosomes is similar to that on the fourth chromosome, but less than that for the X chromosome. There is an overall deficiency of elements in the mid-section of the X compared with the mid-sections of the major autosomes, with considerable heterogeneity between families. The magnitude of this deficiency is positively related to the extent to which elements accumulate proximally. No such deficiency is seen if the proximal regions of the X and autosomes are compared. There is a small and non-significant excess of elements in third chromosomes carrying inversions. There is some between-year heterogeneity in element abundance. The implications of these findings are discussed, and it is concluded that they generally support the hypothesis that transposable element abundance is regulated primarily by the deleterious fitness consequences of meiotic ectopic exchange between elements. If this is the case, such exchange must be very infrequent in the proximal euchromatin, and the elements detected in population surveys of this kind must be inserted into sites where they have negligible mutational effects on fitness.

Corresponding author
*Corresponding author.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

D. J. Begun & C. F. Aquadro (1992). Levels of naturally occurring DNA polymorphism correlate with recombination rate in D.melanogaster. Nature 356, 519520.

V. N. Bolshakov A. A. Zharkikh & I. F. Zhimulev (1985). Intercalary heterochromatin in Drosophila. II. Heterochromatic features in relation to local DNA content along the polytene chromosomes of Drosophila melanogaster. Chromosoma 92, 200208.

B. Charlesworth & D. Charlesworth (1985). Genetic variation in recombination in Drosophila. I. Responses to selection and preliminary genetic analysis. Heredity 54, 7184.

B. Charlesworth & C. H. Langley (1989). The population genetics of Drosophila transposable elements. Annual Review of Genetics 23, 251287.

B. Charlesworth J. A. Coyne & N. H. Barton (1987). The relative rates of evolution of sex chromosomes and autosomes. American Naturalist 130, 113146.

D. L. Hartl J. W. Ajioka H. Cai A. R. Lohe E. R. Lozovskaya D. A. Smoller & I. W. Duncan (1992). Towards a Drosophila genome map. Trends in Genetics 8, 7075.

D. L. Lindsley & G. Zimm (1992). The Genome of Drosophila melanogaster. San Diego: Academic Press.

G. L. G. Miklos & J. N. Cotsell (1990). Chromosome structure at interfaces between major chromosomal types: β-heterochromatin and β-heterochromatin. Bioessays 12, 17.

M. J. Simmons & J. F. Crow (1977). Mutations affecting fitness in Drosophila. Annual Review of Genetics 11, 4978.

W. Stephan T. H. E. Wiehe & M. W. Lenz (1992). The effect of strongly selected substitutions on neutral polymorphism: analytical results based on diffusion theory. Theoretical Population Biology 41, 237254.

S. Tanda A. E. Shrimpton C. Ling-Ling H. Itayama H. Matsubayashi K. Saigo Y. N. Tobari & C. H. Langley (1988). Retrovirus-like features and site specific insertions of a transposable element, torn, in Drosophila ananassae. Molecular and General Genetics 214, 405411.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Genetics Research
  • ISSN: 0016-6723
  • EISSN: 1469-5073
  • URL: /core/journals/genetics-research
Please enter your name
Please enter a valid email address
Who would you like to send this to? *