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Antimicrobial resistance in human populations: challenges and opportunities

  • S. Allcock (a1) (a2), E. H. Young (a1) (a2), M. Holmes (a3), D. Gurdasani (a1) (a2), G. Dougan (a2), M. S. Sandhu (a1) (a2), L. Solomon (a4) and M. E. Török (a1) (a5) (a6)...
Abstract
Abstract

Antimicrobial resistance (AMR) is a global public health threat. Emergence of AMR occurs naturally, but can also be selected for by antimicrobial exposure in clinical and veterinary medicine. Despite growing worldwide attention to AMR, there are substantial limitations in our understanding of the burden, distribution and determinants of AMR at the population level. We highlight the importance of population-based approaches to assess the association between antimicrobial use and AMR in humans and animals. Such approaches are needed to improve our understanding of the development and spread of AMR in order to inform strategies for the prevention, detection and management of AMR, and to support the sustainable use of antimicrobials in healthcare.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
* Address for correspondence: Dr M. E. Török, Department of Medicine, University of Cambridge, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. (Email: et317@cam.ac.uk)
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5. R Smith , J. Coast The true cost of antimicrobial resistance. British Medical Journal 2013; 346: f1493.

6. YY Liu , Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. The Lancet Infectious Diseases 2016; 16: 161168.

7. AH Holmes , Understanding the mechanisms and drivers of antimicrobial resistance. Lancet 2015; 387: 176187.

8. M Woolhouse , Antimicrobial resistance in humans, livestock and the wider environment. Philosophical Transactions of the Royal Society of London B Biological Sciences 2015; 370: 20140083.

9. RS Singer , J. Williams-Nguyen Human health impacts of antibiotic use in agriculture: a push for improved causal inference. Current Opinion in Microbiology 2014; 19: 18.

12. SJ Chandy , High cost burden and health consequences of antibiotic resistance: the price to pay. Journal of Infection in Developing Countries 2014; 8: 10961102.

13. D Ashiru-Oredope , S Hopkins , English Surveillance Programme for Antimicrobial Utilization Resistance Oversight Group. Antimicrobial stewardship: English surveillance programme for antimicrobial utilization and resistance (ESPAUR). Journal of Antimicrobial Chemotherapy 2013; 68: 24212423.

14. JMA Blair , Molecular mechanisms of antibiotic resistance. Nature Reviews Microbiology 2015; 13: 4251.

15. C. Walsh Molecular mechanisms that confer antibacterial drug resistance. Nature 2000; 406: 775781.

17. R Laxminarayan , Antibiotic resistance – the need for global solutions. The Lancet Infectious Diseases 2013; 13: 10571098.

18. H Goossens , Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 2005; 365: 579587.

22. V Krishnasamy , J Otte , E. Silbergeld Antimicrobial use in Chinese swine and broiler poultry production. Antimicrobial Resistance & Infection Control 2015; 4: 17.

23. SA McEwen , PJ. Fedorka-Cray Antimicrobial use and resistance in animals. Clinical Infectious Diseases 2002; 34(Suppl. 3): S93S106.

24. BG Bell , A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infectious Diseases 2014; 14: 13.

25. RL Finley , The scourge of antibiotic resistance: the important role of the environment. Clinical Infectious Diseases 2013; 57: 704710.

26. ECDC (European Centre for Disease Prevention and Control), E.E.F.S.A.a.E.E.M.A. ECDC/EFSA/EMA first joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals. EFSA Journal 2015; 13: 4006.

27. AE Mather , An ecological approach to assessing the epidemiology of antimicrobial resistance in animal and human populations. Proceedings of the Royal Society B: Biological Sciences 2012; 279: 16301639.

28. LB Price , Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock. mBio 2012; 3: e00305e00311.

29. GK Paterson , The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species. Journal of Antimicrobial Chemotherapy 2012; 67: 28092813.

30. EM Harrison , Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC. EMBO Molecular Medicine 2013; 5: 509515.

31. R Datta , Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition. Antimicrobial Resistance & Infection Control 2014; 3: 19.

32. V Schechner , Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance. Clinical Microbiology Reviews 2013; 26: 289307.

33. BV Lowder , Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America 2009; 106: 1954519550.

34. A Voss , Methicillin-resistant Staphylococcus aureus in pig farming. Emerging Infectious Diseases 2005; 11: 19651966.

35. KE Baptiste , Methicillin-resistant Staphylococci in companion animals. Emerging Infectious Diseases 2005; 11: 19421944.

36. E Machado , Antibiotic resistance integrons and extended-spectrum beta-lactamases among Enterobacteriaceae isolates recovered from chickens and swine in Portugal. Journal of Antimicrobial Chemotherapy 2008; 62: 296302.

37. Y Doi , Extended-spectrum and CMY-type beta-lactamase-producing Escherichia coli in clinical samples and retail meat from Pittsburgh, USA and Seville, Spain. Clinical Microbiology and Infection 2010; 16: 3338.

38. M de Been , Dissemination of cephalosporin resistance genes between Escherichia coli strains from farm animals and humans by specific plasmid lineages. PLoS Genetics 2014; 10: e1004776.

39. AE Mather , Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts. Science 2013; 341: 15141517.

40. E Tacconelli , STROBE-AMS: recommendations to optimise reporting of epidemiological studies on antimicrobial resistance and informing improvement in antimicrobial stewardship. BMJ Open 2016; 6: e010134.

41. SJ Leopold , Antimicrobial drug resistance among clinically relevant bacterial isolates in sub-Saharan Africa: a systematic review. Journal of Antimicrobial Chemotherapy 2014; 69: 23372353.

42. T-P van Staa , Pragmatic randomised trials using routine electronic health records: putting them to the test. British Medical Journal 2012; 344: e55.

43. CU Koser , MJ Ellington , SJ. Peacock Whole-genome sequencing to control antimicrobial resistance. Trends in Genetics 2014; 30: 401407.

44. G Lopardo , Antimicrobial stewardship program in a developing country: the epidemiological barrier. Revista Panamericana de Salud Publica 2011; 30: 667668.

45. A Aryee , N. Price Antimicrobial stewardship – can we afford to do without it? British Journal of Clinical Pharmacology 2015; 79: 173181.

46. LM Bebell , AN. Muiru Antibiotic use and emerging resistance: how can resource-limited countries turn the tide? Global Heart 2014; 9: 347358.

47. IN Okeke , Diagnostics as essential tools for containing antibacterial resistance. Drug Resistance Updates 2011; 14: 95106.

49. A Delepierre , A Gayot , A. Carpentier Update on counterfeit antibiotics worldwide; public health risks. Medecine et Maladies Infectieuses 2012; 42: 247255.

50. T Kelesidis , Counterfeit or substandard antimicrobial drugs: a review of the scientific evidence. Journal of Antimicrobial Chemotherapy 2007; 60: 214236.

51. GN Forrest , Use of Electronic health records and clinical decision support systems for antimicrobial stewardship. Clinical Infectious Diseases 2014; 59(Suppl. 3): S122S133.

52. R Pires dos Santos , Hand hygiene, and not ertapenem use, contributed to reduction of carbapenem-resistant Pseudomonas aeruginosa rates. Infection Control and Hospital Epidemiology 2011; 32: 584590.

53. LL. Silver Challenges of antibacterial discovery. Clinical Microbiology Reviews 2011; 24(1): 71109.

54. M Debono , A21978C, a complex of new acidic peptide antibiotics: isolation, chemistry, and mass spectral structure elucidation. Journal of Antibiotics (Tokyo) 1987; 40: 761777.

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Global Health, Epidemiology and Genomics
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