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RCT of post-conflict trauma interventions in the Central African Republic

Published online by Cambridge University Press:  29 May 2025

William John Froming*
Affiliation:
Department of Psychology, https://ror.org/04f812k67Palo Alto University, Palo Alto, CA, USA
Maryke Van Zyl
Affiliation:
Department of Psychiatry, https://ror.org/04g9q2h37San Francisco Veterans Health Administration, San Francisco, CA, USA
Karen Bronk Froming
Affiliation:
Department of Psychology, https://ror.org/04f812k67Palo Alto University, Palo Alto, CA, USA
Vicky Bouche
Affiliation:
Department of Psychology, https://ror.org/04f812k67Palo Alto University, Palo Alto, CA, USA Department of Psychology, https://ror.org/0282qcz50Rady’s Children’s Health, Orange, CA, USA
Sita G. Patel
Affiliation:
Department of Psychology, https://ror.org/04f812k67Palo Alto University, Palo Alto, CA, USA
*
Corresponding author: William John Froming; Email: wfroming@paloaltou.edu
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Abstract

This study evaluates mental health treatment in a post-conflict setting with scant mental health resources. The study reports on a randomized crossover control group design with one intervention and two control groups implemented in the Central African Republic (CAR).

The intervention’s impact on symptoms of depression, anxiety and trauma was analyzed among a sample of 298 participants located in the capital city, Bangui. Participants were screened for elevated levels of anxiety and depression and randomly assigned to one of three groups: control, intervention and active control. Data included an initial interview, measurement following the two intervention workshops and a 3-month post-intervention follow-up.

The trauma reduction intervention significantly reduced symptoms of depression, anxiety and trauma compared to the waitlist control. The active control group focused on peace and value education and produced equivalent outcomes to the trauma-reduction intervention group. Further, at 3 months follow-up, the impact of both interventions remained significant, although lower. The two interventions did not differ from one another.

The study demonstrates two practical approaches for addressing anxiety, depression and trauma symptoms in post-conflict, low-resource settings. The similar outcome of the two interventions may suggest that they share common therapeutic elements.

Information

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2025. Published by Cambridge University Press

Impact statement

The Central African Republic (CAR), one of the most resource-poor countries in the world, has been ravaged by armed conflict for decades. CAR is considered a low- and middle-income country (LMIC; World Health Organization [WHO], 2017), and its people continue to suffer due to significant gaps in mental health treatment. The immense mental health gap in LMIC worldwide is, in part, related to a scarcity of effective programs that address the mental health burden of armed conflict in the civilian population (WHO, 2017). The WHO (2015) has provided suggestions for bridging mental health gaps in LMIC, such as CAR. These suggestions include implementing evidence-based programs through task shifting or task sharing, which involves interventions delivered by nonspecialists.

This study examined the impact of a psychosocial intervention that addressed trauma and compared it to an active control group that emphasized peace and value education and a waitlist control. The trauma-focused intervention, as well as the active control group, significantly reduced mental health symptoms compared to the waitlist control group, suggesting that these interventions may share common factors (Pedersen et al., Reference Pedersen, Lakshmin, Schafer, Watts, Carswell, Willhoite, Ottman, van ‘t Hof and Kohrt2020). In addition, these empirically supported mental health interventions were delivered by nonspecialists from the region, providing support for task shifting (WHO, 2022) to address gaps in treatment.

These interventions offer a way to reduce the levels of distress among communities in post-conflict societies, thereby increasing the capacity to reengage with their families and their economic tasks, helping to restore a sense of normalcy. Beyond the impact of these interventions on the people of CAR, this work supports the task-shifting model as well as immediate brief psychosocial interventions.

Introduction

One in five people who have experienced armed conflict develops a mental health diagnosis within 10 years, which may include depression, anxiety, post-traumatic stress disorder (PTSD), bipolar disorder or schizophrenia (Charlson et al., Reference Charlson, Ommeren, Flaxman, Cornett, Whiteford and Saxena2019). Other symptoms experienced when exposed to armed conflict include social isolation, emotional distress, insomnia, family conflict and a tendency toward aggressive or risky behavior (Van der Kolk et al., Reference Van der Kolk, Van der Hart, Burbridge, Hobfoll and de Vries1995; Betancourt et al., Reference Betancourt, Speelman, Onyango and Bolton2009; Dorrepaal et al., Reference Dorrepaal, Thomaes, Smit, van Balkom, van Dyck, Veltman and Draijer2010). Post-conflict settings present a complex, interactive milieu of social and structural determinants of health inequalities, including mental health, involving most aspects of day-to-day living. Furthermore, the most vulnerable members of the population are women, children, internally displaced persons and people with preexisting symptoms of mental illness (Bwirire et al., Reference Bwirire, Crutzen, Namegabe, Letschert and de Vries2022).

In addition to the mental health burden on individuals, family systems are significantly impacted by armed conflict through the loss of lives (Weine et al., Reference Weine, Muzurovic, Kulauzovic, Besic, Lezic, Mujagic, Muzurovic, Spahovic, Feetham, Ware, Knafl and Pavkovic2004), family separation and displacement (Bass et al., Reference Bass, Annan, McIvor Murray, Kaysen, Griffiths, Cetinoglu, Wachter, Murray and Bolton2013) and financial strain (Patel, Reference Patel2012). Families are often displaced and separated during armed conflict and experience severe losses in social and financial support, leaving survivors to take on multiple caregiving roles on behalf of those who were displaced, left behind, injured or killed. The effects of trauma on families can be long-standing and intergenerational, leading to ripple effects that negatively impact communities long after a conflict has ended (Pearrow and Cosgrove, Reference Pearrow and Cosgrove2009; Bezo and Maggi, Reference Bezo and Maggi2015; Sangalang and Vang, Reference Sangalang and Vang2017). Where neighbors with different ethnic or religious backgrounds may have coexisted or even coalesced in a pre-conflict society, communities are often fractured due to public misinformation, politically charged bias and interethnic conflict (Ajdukovic and Biruski, Reference Ajdukovic and Biruski2008). The cycles of conflict-inflicted poverty and trauma have been well-documented (Lund et al., Reference Lund, De Silva, Plagerson, Cooper, Chisholm, Das, Knapp and Patel2011; Patel, Reference Patel2012; Chisholm et al., Reference Chisholm, Sweeny, Sheehan, Rasmussen, Smit, Cuijpers and Saxena2016; Patel et al., Reference Patel, Saxena, Lund, Thornicroft, Baingana, Bolton, Chisholm, Collins, Cooper, Eaton, Herrman, Herzallah, Huang, Jordans, Kleinman, Omigbodun, Prince, Rahman, Saraceno, Sarkar, de Silva, Singh, Stein, Sunkel and Unutzer2018) regarding the broad community burdens.

Violent conflict in the CAR

The current study was conducted in the CAR. CAR has many ethnic groups (e.g., Twa, Gbaya, Banda, Mandjia, Sara, Mbum and Ngbaka ethnic groups) and an extensive history of interethnic, interreligious and colonial conflicts (Carayannis, Reference Carayannis and Lombard2015; Lombard, Reference Lombard2016). CAR has experienced decades of political instability and violence, including six governmental coups (Gang et al., Reference Gang, O’Keefe and Roberts2023). In a recent outbreak of violence, starting in 2013, an alliance of predominantly Muslim militia groups named Seleka overthrew the government and seized power. An alliance of predominantly Christian militia groups, known as the Anti-balaka, responded and drove the Seleka out of the capital city of Bangui. During this period, ~1.2 million people were displaced, either internally or to surrounding countries, and several thousand were killed (United Nations High Commissioner for Refugees [UNHCR], 2024). More recently, the UN peacekeeping forces have increased, and ongoing violence still occurs regularly (Global Centre for the Responsibility to Protect [GCR2P], 2025; UNHCR, 2024; World Bank, 2024).

Unfortunately, CAR lacks the mental health infrastructure to manage the psychological consequences of the conflict. CAR has almost none of its own healthcare (Baleta, Reference Baleta2021; United Nations Office for the Coordination of Humanitarian Affairs, 2024) or mental health resources (Vinck and Pham, Reference Vinck and Pham2010), with only one practicing physician with psychiatric training in a country of 4.6 million people at the time of this study (Baxter and Allison, Reference Baxter and Allison2020). Current population estimates suggest an increase to over 6 million people, with some psychosocial workers providing services to only 2,982 people in 5 district health centers (World Bank, 2024). Mental health resources are primarily provided by nongovernmental organizations (NGOs; Bass et al., Reference Bass, Neugebauer, Clougherty, Verdeli, Wickramaratne, Ndogoni, Speelman, Weissman and Bolton2006), which means that providers are typically trained in the United States or Europe, work primarily in the capital and tend to only stay for a few months (Baxter and Allison, Reference Baxter and Allison2020), leaving the community in flux. This model of mental healthcare is unsustainable, provides only temporary care and does not utilize local resources.

To provide quality global mental health care for all, a few key strategies have enabled more people to access appropriate care (Patel and Thornicroft, Reference Patel and Thornicroft2009; WHO, 2019). These strategies include thorough needs assessments (Patel, Reference Patel2012; Becker and Kleinman, Reference Becker and Kleinman2013), adapting Eurocentric approaches to the relevant context (Bolton et al., Reference Bolton, Bass, Neugebauer, Verdeli, Clougherty, Wickramaratne, Speelman, Ndogoni and Weissman2003; Patel et al., Reference Patel, Unanue, Crittenden, Kieschnick, Froming, Brown, Ntakarutimana, Bertrand Lazaret, Dailami and Froming2020) and involving local stakeholders, such as community members and religious leaders, through task shifting (Patel et al., Reference Patel, Unanue, Crittenden, Kieschnick, Froming, Brown, Ntakarutimana, Bertrand Lazaret, Dailami and Froming2020). Before implementing mental health programs, a thorough understanding of the population, possible barriers and common challenges experienced by similar organizations (Patel, Reference Patel2012; Becker and Kleinman, Reference Becker and Kleinman2013) is necessary.

The present study

The conflict in CAR, which started in 2012–2013 between the Seleka and the anti-Balaka, came to the attention of the UN Security Council. A Commission (The International Commission of Inquiry on the Central African Republic) was appointed and a report was filed on the situation (United Nations Security Council, 2014). The report noted the death and destruction already present, and that CAR was vulnerable to additional violence. While it did find genocidal acts had occurred, it did not find evidence of genocidal intent on the part of any of the combatant groups but did not rule it out for the future.

The situation continues to be dire with violence and insecurity erupting periodically. It was recently estimated that about 60% of the population is traumatized (Dozio et al., Reference Dozio, Dill and Bizouerne2021). In response to the complex and extreme humanitarian crisis, the US Agency for International Development developed a multipronged plan for improving the CAR situation: (1) promote civil institutions in establishing a leadership role in peacebuilding, (2) reestablish livelihood security and (3) foster social cohesion through psychological intervention. The plan was carried out by a number of NGOs that were already active in CAR: Catholic Relief Services (CRS), Aegis Trust (AT), Islamic Relief Worldwide (IRW) and World Vision International (WVI).

The focus of this study centers on the effort to improve mental health conditions in the traumatized population (the third of the goals outlined above). Identifying empirically supported treatment(s) for improving mental health during quiet periods or in post-conflict situations can improve the lives of individuals and their social networks. The current study rigorously tested the efficacy of a trauma reduction intervention that had not been subjected to extensive testing. Two comparison groups were included. The study utilized cross-culturally validated measures, independent data gatherers and a randomized crossover design. We build on our earlier work (Patel et al., Reference Patel, Unanue, Crittenden, Kieschnick, Froming, Brown, Ntakarutimana, Bertrand Lazaret, Dailami and Froming2020), which not only sheds light on the dire need for mental health services in CAR but also provides vital information to guide culturally congruent interventions. Findings from that study confirmed the prevalence of traumatic experiences and traumatic stress among survivors of armed conflict in this region, as also found in previous studies (Bolton, Reference Bolton2001; Bass et al., Reference Bass, Neugebauer, Clougherty, Verdeli, Wickramaratne, Ndogoni, Speelman, Weissman and Bolton2006; Vinck and Pham, Reference Vinck and Pham2010; Patel et al., Reference Patel, Unanue, Crittenden, Kieschnick, Froming, Brown, Ntakarutimana, Bertrand Lazaret, Dailami and Froming2020). Patel et al. (Reference Patel, Unanue, Crittenden, Kieschnick, Froming, Brown, Ntakarutimana, Bertrand Lazaret, Dailami and Froming2020)) described conducting focus groups in CAR that yielded the following three themes: (1) the need to reestablish safety, (2) trauma experiences and local manifestations of distress and (3) local mental health treatment.

Two task-shifting interventions were implemented by community leaders who had been trained by CRS and Aegis staff members. The first intervention, Healing and Rebuilding Our Communities (HROC), was explicitly intended to improve aspects of mental health by reducing high levels of anxiety, depression and trauma symptoms as culturally described by community members. Prior workshop participants reported that they found the workshop very helpful, and it has been used in several countries in sub-Saharan Africa, the United States and Canada. Yeomans et al. (Reference Yeomans, Forman, Herbert and Yuen2010) used two variants of HROC and a waitlist control group in Burundi to examine the efficacy of HROC. They found both versions of HROC improved trauma symptom reporting but not broader measures of stress. The remainder of available unpublished outcome data are generally limited to pre- and posttest ratings on the Harvard Trauma Questionnaire (HTQ) and the Hopkins Symptom Checklist (HSCL-25) along with informal comments (Karen B. Froming, personal communication, 2015).

The second intervention, AT’s Peace and Values Education (PVE) was developed in the aftermath of the Genocide Against the Tutsi in Rwanda. Based on the work of Staub (Staub, Reference Staub1994, Reference Staub2015) and Stanton (Reference Stanton1999), it utilizes an African modality of oral history and storytelling (Afriklens, Reference Afriklens2024).

Community is at the heart of African oral traditions. Storytelling sessions are not solitary activities but communal gatherings where people of all ages come together to engage in a shared experience. These gatherings allow communities to bond, transmit collective values, and celebrate their heritage. In African societies, storytelling is often performed in an interactive manner, with the audience responding to prompts or adding their input. This participatory element creates a dynamic atmosphere and strengthens the connection between the storyteller and the audience.

The ultimate goals of PVE were to experientially learn about empathy, tolerance, critical thinking and personal responsibility through facilitated dialogue. Although the PVE intervention has merit as a standalone workshop and has been adopted by schools throughout Rwanda, its content was not designed to improve emotional and mental health per se. Its intent is to improve critical thinking skills, empathy and social responsibility, thereby hoping to prevent people from falling prey to genocidal ideology. By comparing the impact of HROC to PVE, we hoped to better understand the critical components of the HROC intervention. The following provides a detailed description of the three experimental groups:

1. HROC was derived from the Quaker program “Alternatives to Violence Project” (AVP). AVP was created in 1975 for work with prisoners (John, Reference John2021). HROC originated in Rwanda in 2003 in the aftermath of the Genocide against the Tutsi in 1994. Groups of 15–25 individuals gather for a 3-day workshop. When feasible, group composition consists of members from each side of the conflict; in CAR, that meant Christians (Catholics and Protestants) and Muslims, as well as men and women. This will be discussed in more detail in the Methods section. Day 1 of the workshop is psychoeducational and skill-building. Presentations and discussions center on differentiating between normal and traumatic stress, defining traumatic stress symptoms and their health effects. Trauma-focused self-help skills are then introduced and practiced. Day 2 involves learning active listening techniques and the discussion of loss, grief and anger through limited and confidential sharing of personal testimonies. Despite complex content, empathy is a byproduct of sharing, as violence has negatively impacted all. Day 3 focuses on mistrust and the development of trust through communal activities. More information is available on the HROC website and in the manual, which can be retrieved here: https://healingandrebuildingourcommunities.org/philosophyandapproach/. The workshops are typically led by two to three individuals who have participated in a prior workshop and then attended a 5-day training program to qualify them as leaders. They are usually psychologically minded community members with credibility (e.g., community members, religious leaders and teachers).

2. The PVE workshop was developed by AT (https://www.aegistrust.org/) in Rwanda and was culturally adapted for use in CAR. The workshop lasts 2 days and is led by two to three leaders trained by AT. The overarching goals are to develop knowledge, personal attitudes and cognitive and behavioral skills that will lead the trainees to pursue and engage in positive activities in the future. Similarly, these same factors will reduce the likelihood of the participants being influenced by opposing (i.e., genocidal) ideologies and activities in the future. The workshop seeks to “inoculate” the participants should they face conditions like those present in pre-genocide Rwanda.

The first day consists of psychoeducation about the shared colonial history of the country, discussion and exercises on cycles of violence, genocide, loss of social cohesion and witness stories. The second day focuses on the future with stories of humanity and various exercises to promote the workshop’s goals. Exercises on this day explore topics, such as the road to peace, cycles of benevolence, forgiveness, critical thinking and prosocial action.

3. Waitlist control group. The third group in the study was a passive waitlist control group. The participants were assessed at the same time as the members of the intervention groups. They received no active treatments during the study, but participated in both treatments when the data-gathering phase concluded.

The group facilitators were experienced workshop leaders from CRS and AT. In addition, local religious and civic leaders joined in leading the workshops and provided credibility, local knowledge and translation assistance if needed.

Comparing the two interventions

The HROC intervention focuses on the trauma experienced by the individual, for example, its origins and symptoms, while normalizing responses to extreme stressors. Participants share some traumatic experiences that invariably generate mutual empathy and commonality among group members. HROC helps participants share their anger and loss while introducing coping strategies and exercises specific to the trauma responses. Finally, the shared experience in the workshop enables all community members to begin building social cohesion. (Table 1).

Table 1. Comparison of HROC and PVE

Note: Both workshops had activities and exercises interspersed throughout the day. The exercises were mood enhancing and/or socially interactive. They also dined together at lunch and at a tea break.

The PVE program focuses on genocide (e.g., its origins with its ties to the colonial past, failed governance and inequities among members of the group/society that produce violence. The workshop draws on examples of genocides from around the world, forgiveness and ways to counteract/prevent genocide. It utilizes Socratic questioning to engage participants in discussion of shared history and didactics related to cycles of violence as well as the cycle of positive, prosocial behavior to reduce the likelihood of violence.

Thus, the content focus of the two interventions is different, as are the kinds of exercises and analyses used. However, both interventions are group interventions that aim to bring together participants from both sides of the conflict. Each intervention demonstrates and encourages active listening and interactive discussion of the material. The next phase introduces storytelling and testimonies, as well as exercises for coping. Through this phase, the identification of the commonality of experience and emotional impacts is discussed. As mentioned, PVE was not designed to improve mental health. A fair test of the PVE intervention’s ability to meet its intended goals would employ different outcome measures than the ones used here. Such an analysis is beyond the scope of this article.

With limited empirical support in the literature for HROC as an effective mental health treatment for lowering stress-related emotions, the first hypothesis is whether HROC reduces stress more than the waitlist control group. In the context of this study, the PVE group then forms a critical comparison group for interpreting the outcomes of the HROC intervention. HROC primarily focuses on traumatic events that the participants have already experienced. PVE looks ahead as it seeks to prevent the participants from succumbing to genocidal ideology that they may be exposed to in the future. There is no data in the literature documenting that PVE impacts mental health variables, and as mentioned earlier, it was not designed to do so. Essentially, then, the PVE intervention will function as an active control condition. This study will examine that possibility. In addition, the two interventions may interact. For example, a discussion of society’s role in creating the distal conditions leading up to the conflict (PVE) might lead to a greater appreciation of the proximal causes of one’s personal trauma (HROC). Conversely, the HROC intervention may make participants in the PVE groups more receptive to that content.

If HROC produces significant changes in the dependent variables compared to the other two groups, all else assumed equal, the trauma focus can be assumed as the mechanism of change. If both HROC and PVE produce similar positive results (with no interaction), then we must consider whether they share anything in common that may explain their similar outcomes.

Methods

Recruitment and sample selection

The initial pool of participants was 1,103 adults who lived in Bangui in 2017. Religious leaders nominated many individuals for participation based on the leaders’ belief that the individuals had suffered significantly because of the conflict. The senior religious leaders broadcast their joint support and advertised the work being done in an effort to quell the perception that the violence was faith-based. These leaders included the Catholic Archbishop (i.e., the senior Catholic prelate in CAR), the President of the Islamic Council (the senior Imam) and the President of CAR’s Evangelical Alliance. These religious leaders provided both nominations of local religious leaders and explicit permission for them to cooperate with the project. The research team visited local churches and was introduced by the church leader, after which they answered questions from the community about the project. Using snowball sampling, these initial participants spread the word and others volunteered to be interviewed.

The HSCL-25 was chosen as the screening device for the study. Meeting the HSCL-25 cutoff of 1.75 as well as age (i.e., adults over 18 years of age) were the only inclusion criteria. It is a brief screening instrument and targets two major components of PTSD (Barbano et al., Reference Barbano, van der Mei, deRoon-Cassini, Grauer, Lowe, Matsuoka, O’Donnell, Olff, Qi, Ratanatharathorn, Schnyder, Seedat, Kessler, Koenen and Shalev2019). The HSCL-25 has been used in diverse cultural settings around the world and has been found to have good structural integrity (e.g., see Wind et al., Reference Wind, van der Aa and Knipscheer2017). While studies showed some differences, the general pattern is that the HSCL-25 factor structure replicates across these varied samples. The cutoff points can vary slightly across studies (Christy et al., Reference Christy, Siriwardhana, Lohmann, Roberts and Smith2021), but Mollica recommended 1.75, which we adopted.

The original pool of 1,103 individuals was screened using the HSCL-25, and 502 were eligible for participation because their HSCL-25 score was 1.75 or higher (Ventevogel et al., Reference Ventevogel, Scholte, Shinwari, Faiz, Nassury, van den Brink and Olff2007; Mollica, Reference Mollica2012). The mean HSCL-25 score of the 298 participants in the study was 2.61, SD = 0.44. From the eligible participants, 143 were included in a pilot study to train the assessors, clear up any questions about testing procedures and identify issues with the accuracy of translation. That left a pool of 359 eligible participants (Table 2).

Table 2. Sample-selection flow chart

Note: Other scales had missing data as well (e.g., eight participants did not respond to some questions on the HTQ).

The remaining 359 participants were called and invited to participate in the workshops. Some people were unreachable, and some could not commit to the time requirements. The workshops were scheduled in rooms that would accommodate 20–25 participants plus workshop leaders. Typically, these rooms were in a local hotel conference room and occurred during the day. Thus, the time of day and time across multiple sessions were factors impacting who could be scheduled. The final number of participants was 298, defined as people who participated in at least three of the four assessment sessions (i.e., people who participated in the pretest, the two workshops and at least two of the three post-workshop assessment sessions). Those who were not scheduled were lost for several reasons, including being unavailable at the designated time(s), difficulty contacting them and limited numbers of workshops, among others.

A few (N = 8) participants declined to answer questions on the HTQ. We did not query them as to why they made this choice, given the personal nature of the questions, and we decided not to exclude these participants from the study as these questions were not central to our evaluation. Details of trauma experiences gathered from the HTQ (N = 290) are presented in Table 3.

Table 3. Self-reported traumatic events on a modified version of the Harvard Trauma Questionnaire

Sample size

Assuming a medium effect size, α = .05 and β = .8, the recommended sample size was 44 participants per group or 132 in total. With the unsettled conflict environment present in CAR, we did not know how many participants would be lost over the course of the study. Therefore, we increased our sample size goals to 100 per group to guard against significant attrition.

Participants

Participants (N = 298) were 70% male and 30% female, with an average age of 37.41 (SD = 12.97). The breakdown of religious affiliations was 25% Catholic, 42% Protestant and 27% Muslim. An additional 5% of the participants did not state a religious preference. It should be noted that the United States Department of State (2021) estimates the prevalence of religions in CAR as 61% Protestant, 28% Catholic, 9% Muslim and 2% other religious groups. Therefore, our sample overrepresents Muslims and underrepresents Protestants.

The single greatest factor contributing to the failure to complete the program was the 3-month follow-up. Of those who completed the program (missing no more than one assessment), 43 of 45 misses were in the follow-up session. Only two people missed a different session, but attended the follow-up session.

Study design

Eligible participants were assigned to conditions using a random number generator.

They were randomly assigned to receive either an HROC workshop or a PVE workshop first, followed by the other workshop approximately a week later. A third group was waitlisted and assessed at the same intervals as the two treatment groups. Participants stayed in the same groups when possible. If someone missed a session, they could attend a different group to make up for it.

This resulted in a randomized crossover clinical design. Thus, participants were assessed four times throughout the process (i.e., before any workshops, after the first, after the second and 3 months later).

Interviews and interviewers

An initial translation of the interview questions was performed by one of the team members who was trilingual. Interviewers were recruited by Echelle, a local organization recommended by other researchers in CAR. The interviewers were fluent in both Sango and French. Before conducting the interviews, the research team worked closely with interviewers to resolve any confusion over the meaning of the items as they were translated. The data questions were read in either Sango or French to the participants because literacy could not be assumed.

A 2-day workshop was then held for members of the research team together with interviewers. One half-day of the workshop was about the use of the KoboToolbox software and computer tablets. Most of the time was spent reviewing and discussing item translation to ensure that the meaning and intent of the question were maintained. When consensus was reached on the interview questions and the interviewers were able to operate the tablets, interviews could begin. For the first set of pilot interviews, the senior member of the research team was present to oversee the data gathering and address any questions.

In the original sample of 1,103, 96% did the assessment in Sango, 2.25% did it in Arabic and the remainder did it in French or one of the other local languages. Of the 298 who were included in the study, 296 completed the assessments in Sango and two in French. The answers were input in Sango on tablets using KoboToolbox software. The data were stored numerically so they could be interpreted directly by the data analyst without further translation.

All interviews were one-on-one, lasting about 1–2 h, and were conducted in the participants’ neighborhoods whenever possible. When this was not possible, the participants traveled to an office or community space that minimized distractions. In these cases, participants were reimbursed for their travel expenses. Payments were restricted to transportation costs for each session completed. Refreshments were provided during the workshops as well.

Raw answers to the 1,103 initial interviews were sent via an electronic file to the senior researcher. Participants who met the selection criteria were identified (N = 502). Training of the interviewers was conducted on 143 eligible participants, and thus disqualified them from the main study. Groups of 15–25 individuals were then formed using blocking factors: sex and religion (Catholic, Protestant, Muslim and other [e.g., animists]). Members of the group were called by a research team member to schedule their attendance in one of the three conditions, and 298 were successfully scheduled. Neither the people making the calls nor the participants knew to what group they were being assigned.

Measures

The extensive interview questionnaires used in this study included instruments that were cross-culturally validated in settings around the globe and included the HSCL-25, the HTQ (Mollica et al., Reference Mollica, McDonald, Massagli and Silove2004) and the PTSD Checklist-5 (PCL-5). These instruments were translated and back-translated by team members fluent in English and Sango. Additional local experts in Sango/French translated/back-translated twice from English to Sango, and from French back to Sango. Constraints of the present study environment (funding, security situation and rapid needs for implementation) did not allow for an in-depth cross-validation of each instrument.

The HSCL-25, which was used as a screening measure, was discussed earlier in this section. For this measure, individual responses can range from 1 (not at all) to 4 (extremely) on each item. The PCL-5 measures DSM-5 symptom criteria for PTSD. The PCL-5 is a 20-item self-report measure. Responses range from 0 (not at all) to 4 (extremely) on each item. The PCL-5 has cross-cultural support from other studies (e.g., Lima et al., Reference Lima, Vasconcelos, Berger, Kristensen, Nascimento, Figueira and Mendlowicz2016). In considering whether to use the PCL-5 or HSCL-25, we decided to include both as they are both relevant to what we wanted to measure; however, we were looking for broad post-trauma symptom distress rather than diagnosing PTSD according to the Diagnostic and Statistical Manual-5. It should be noted that over half the sample (54%) reported that they had no education, and another 24% did not finish elementary school.

Responses to the HTQ provided evidence of the type and extent of the trauma the study participants had experienced. Over 89% of the participants reported witnessing pillaging and beatings, and 77% witnessed killings. Most (93%) of them had been forced to flee, and 91% were expected to die. Thus, the participants reported exposure to traumatic events and elevated levels of anxiety and depression, as measured by the HSCL-25.

Institutional review

The institutional review for the study was carried out at Palo Alto University, as there was no functioning review board in Bangui. We sought consultation with an IRB in CAR regarding the proposed study, but due to the armed conflict, the University of Bangui was functionally shut down and we were unable to locate an IRB. The proposed study was discussed with a psychology professor at the University of Bangui, in an effort to approximate an in-country ethical review. The professor and some of the local NGO (CRS, AT, IRW and WVI) leaders supported the effort as its goal was to investigate treatments for widespread trauma that existed in the wake of the conflict. Dozio et al. (Reference Dozio, Dill and Bizouerne2021) described a similar situation.

Results

Preliminary analyses

Study participants

Scores on the HSCL-25 > 1.75 were the basis for eligibility for the study. They were randomly assigned to conditions blocked by sex and religion. The distribution within the groups by sex and religion is displayed in Table 4.

Table 4. Sex and religion

Note: Eight participants did not answer this question.

Within each experimental group, the χ 2 value is not significant. Across all participants, the χ 2 is significant, p < .01. This finding is partly due to low expected frequencies in some of the cells; however, eliminating the category of “other religions” does not eliminate the problem. It appears to be the result of larger male/female ratios among Christians and “other” religions compared to Muslims, who were roughly equally divided by sex. We were unable to more fully explain this finding.

We did not find any differences between the larger pool of qualifying participants and the actual study participants. About 17% of the qualifying pool did not participate in the actual study. Initial participation in the study was done on recommendations by clergy, imams and local leaders and done by word of mouth. Contacting potential participants to schedule them for the workshops was done by phone. While phones were/are relatively common in CAR, the living situation was very chaotic. The chaos may have introduced any number of factors that made some people easier to contact than others. The loss of 43 participants at the 3-month follow-up raised the concern that they might be different from those who participated. To address this, scores of the HSCL-25 on the third assessment were computed for the 43 participants who were not in the fourth assessment, compared to the other participants who were in the third and fourth assessments. This comparison was not significant, indicating that the participants leaving after the third assessment did not differ from those who went on to complete the fourth assessments.

Psychological measures

In the current study, the internal reliability of the HSCL-25 Anxiety Subscale was Cronbach’s α = .89. For the HSCL-25 Depression Subscale, Cronbach’s α = .80 and the PCL-5 scale had Cronbach’s α = .89. The correlation between the two HSCL-25 subscales was .55 (p < .001) and the correlation between the full scale HSCL-25 and the PCL was .62 (p < .001). Correcting for the restriction in range in the sample, using Thorndike’s (1949) method, the PCL-5 correlation with the HSCL-25 was .95, indicating that the two measures were tapping into the same construct.

Before turning to the main analysis, it needed to be established that the random assignment of participants to groups had been successful. A one-way analysis of variance (ANOVA) of the HSCL-25 scores by treatment group at Time 1 was not significant, F(2, 287) = .65, ns. This indicates that the random assignment process was successful.

Main analyses

The central question asked by the study was whether the treatments (HROC or PVE) significantly reduced anxiety and depression (as measured by the HSCL-25) in the participants compared to the waitlist control group. A mixed-design ANOVA was conducted to answer this question. There were four assessments, three groups of participants and two sexes. For this analysis, the total number of subjects with complete data was 253, and the dependent variable was the HSCL-25 mean scores.

The principal analysis produced three significant main effects: sex, experimental condition and assessment and one two-way interaction. The main effect for sex (F = 1, 247) = 4.58, p < .04) involved males having higher overall HSCL-25 scores (M = 2.19) compared to females (M = 2.07). The main effects of the experimental condition and assessment were also significant but are best understood in the context of the significant interaction of treatment group × assessment (F = 5.88, df = 5.88, 725.51 [using Greenhouse–Geiser correction], p < .001). Figure 1 shows the graph of the interaction.

Figure 1. Results for three experimental groups by four assessments on mean HSCL-25 scores.

Additional analyses found that this pattern was true for both the anxiety and depression subscales on the HSCL-25.

The HROC/PVE and PVE/HROC groups were analyzed independently of the control group to better understand the interaction. Recall that the PVE group was considered an active control group. An analysis of covariance (with sex as the covariate) found that these two conditions (i.e., the main effect) were not significantly different from each other overall, F(1, 170) = 0.01, ns. In addition, the interaction between the two conditions and the assessment factor was not significant, F(2.97, 504.13) = 3.54, ns. Therefore, the two experimental conditions were combined for the next set of analyses.

Comparing the combined treatment groups with the control group over the four assessments and using the HSCL-25 mean scores as the dependent variable and sex as a covariate produced a significant interaction, F(2.94, 734.88, using Greenhouse–Geisser correction) = 7.46, p < .0005. See Figure 2 below. The combined treatment groups reduced symptoms more quickly and to a greater degree over time than the waitlist control group.

Figure 2. Combined workshop groups compared to the waitlist control group on mean HSCL-25 scores.

To better understand the nature of the interaction, a series of interaction contrasts were performed, enabling an understanding of the impact of the combined HROC + PVE and the control group between Time 1 and Time 2 (after the first workshop), Time 2 and Time 3 (after the second workshop) and Time 3 to follow-up Time 4. These were 2 × 2 comparisons, with one factor being the two intervention groups (i.e., the combined treatment groups and the control group), and the second was the two assessment times. The first of these analyses produced a significant interaction, F(1, 296) = 11, p < .001. Given that the two treatment conditions were not different at the pretest Time 1 (t (296) = 0.91, ns), the interaction indicated that the groups did differ at the second assessment (t (296) = 4.14, p < .001). The combined treatment group had significantly greater symptom reduction than the control group. Figure 3 illustrates that the combined treatment group had significantly lower symptom severity scores on the HSCL-25 than the control group at Time 2.

Figure 3. PCL-5 mean scores for combined treatment groups and waitlist control group.

Moving to the second interaction contrast, the main effect of the combined intervention group versus the waitlist control group was significant, F(1, 294) = 21.80, p < .001, but the interaction was not F(1,294 = 1.03, p > .05). This result indicated that the difference between the combined treatment group and the control group comparison found in Assessment 2 was maintained in Assessment 3.

The final interaction contrast produced a significant interaction, F(1, 251) = 7.77, p = .006. At the third assessment, the groups were significantly different, t (294) = 5.66, p < .001, with the combined treatment group having significantly lower anxiety/depression severity scores than the control group. This group difference was still significant at the fourth assessment, t (253) = 2.45, p = .02, but to a lesser extent than at the third assessment. Thus, symptom reduction was maintained, but to a lesser degree.

To summarize, the level of symptom distress at baseline in the two combined treatment groups (HROC and PVE) and the control group started equal to each other. Both HROC and PVE proved effective in reducing anxiety/depression compared to the control group. These improvements were maintained after the second treatment was delivered. By the 3-month follow-up, the differences were still significant but less so.

Finally, the impact of the workshop interventions was examined on the PCL-5 scores. The interaction between the combined treatment groups and the control group was significant, F(5.78, 719.58, with Greenhouse–Geisser correction) = 3.70, p = .009. The results of this analysis paralleled those obtained when examining the HSCL-25. They are displayed in Figure 3.

Discussion

The study has demonstrated that, even in conflict zones, important steps can be taken to reduce the suffering of the local population. The HROC intervention significantly reduced anxiety, depression and traumatic stress symptoms for up to 4 months compared to the waitlist control group. There is substantial support in the global mental health community for the efficacy of psychosocial and brief psychological interventions that can be delivered by trained laypeople (Murray et al., Reference Murray, Dorsey, Bolton, Jordans, Rahman, Bass and Verdeli2011; WHO, 2015; 2022; 2023; Haroz et al., Reference Haroz, Nguyen, Lee, Tol, Fine and Bolton2020; Okoroafor and Christmals, Reference Okoroafor and Christmals2023). The current study is an example of how global mental health strategies, particularly research, evidence-based care, cultural adaptation and task shifting, may be implemented to broadly address traumatic distress and mental health concerns. This study employs a systematic empirical approach to evaluate the efficacy of psychosocial and peacebuilding interventions in the context of limited resources. The anxiety, depression and trauma symptom measures used in this study are consistent with other studies utilizing them in other international contexts (Lima et al., Reference Lima, Vasconcelos, Berger, Kristensen, Nascimento, Figueira and Mendlowicz2016; Mughal et al., Reference Mughal, Devadas, Ardman, Levis, Go and Gaynes2020). The measures used in this study were also supported by the Patel et al. (Reference Patel, Unanue, Crittenden, Kieschnick, Froming, Brown, Ntakarutimana, Bertrand Lazaret, Dailami and Froming2020) study from the same community examining anxiety, depression and traumatic stress symptoms.

Initial support for the HROC intervention came from Yeomans et al. (Reference Yeomans, Forman, Herbert and Yuen2010) and unpublished, informal feedback from earlier international cohorts. Participants reported reduced symptomatology, gained a better understanding of their symptoms and requested additional workshops to continue their recovery. What was more surprising was the impact the PVE workshops had on mental health variables. The PVE workshop was designed to inoculate participants against genocidal ideology and to make clear that there were stages to increasing aggression to genocidal levels and barriers to escalation through engaging in different positive dialogues and behaviors for peaceful solutions.

The significant differences between the HROC intervention group and the waitlist control provide empirical support for this intervention. However, the PVE intervention group provides crucial information on how we interpret the impact of the HROC intervention. The results indicated that the two treatment groups did not significantly differ. As noted earlier, the PVE was intended to be an active control group. Its subject matter focused on the CAR’s colonial history and episodes of repeated mass violence that could lead to genocide. It aimed to discuss ways of identifying and intervening in the cycles of violence that lead to genocidal ideology. When typically deployed, PVE target outcome questions were related to changes in social relationships, attitudes toward conflict resolution and revenge versus dialogue. In contrast, the HROC intervention focused on education about distress symptoms as an expected reaction to violence, grief, loss and anger, as well as the commonality of experience in civil war and how the symptoms could be managed. Thus, the interventions significantly differ in their content. Examples of this may be found in the comments of workshop participants, which clearly distinguished which workshop a participant attended.

While the substantive content of the two interventions focused on different topics (i.e., individual psychological distress vs. resisting or accepting retributive social norms), the two interventions produced comparable and positive outcomes (compared to the waitlist control). Explanations are likely to lie in the common group factors employed in the two interventions (McAleavey and Castonguay, Reference McAleavey, Castonguay, Gelo, Pritz and Rieken2014; Patel et al., Reference Patel, Unanue, Crittenden, Kieschnick, Froming, Brown, Ntakarutimana, Bertrand Lazaret, Dailami and Froming2020). Common factors found in treatment manuals may explain why our distinct interventions yielded similar results. Common factors research in psychotherapy outcomes has been discussed for decades, and more recently has been applied to brief psychosocial interventions in global mental health research. It may help explain why so many different psychosocial interventions in LMIC produce positive results.

LMIC psychosocial interventions are dependent upon the existing infrastructure and personnel. If infrastructure/personnel are minimal, then laypeople trained to deliver services through task shifting are utilized. With greater infrastructure/personnel, task sharing may be undertaken with mental health supervision of trained laypeople. These different models of service delivery often dictate the length of treatment that can be accomplished, usually between 1 and 18 sessions, but averaging around 8 sessions. In addition to this, earlier research on psychosocial interventions began with limited sessions or workshops. More recently, treatments have expanded to include transdiagnostic, symptom cluster-specific problems that can be treated in the short-term as needs arise (Murray et al., Reference Murray, Dorsey, Haroz, Lee, Alsiary, Haydary, Weiss and Bolton2014; Singla et al., Reference Singla, Kohrt, Murray, Arpita, Chorpita and Patel2017). Furthermore, recent research (Patel et al. Reference Patel, Chisholm, Parikh, Charlson, Degenhardt, Dua, Ferrari, Hyman, Laxminarayan, Levin, Lund, Medina Mora, Petersen, Scott, Shidhaye, Vijayakumar, Thornicroft and Whiteford2016; Singla, Reference Singla2021) suggests that the evidence gathered from global mental health work has demonstrated that psychosocial and targeted symptom-cluster interventions can be utilized in the same way in High income countries (HIC) that also have a limited supply of professionals for great demand and cost.

Our interventions fall into the former category of workshop interventions in a post-conflict/conflict environment. There was essentially no infrastructure, and one general medical provider with some mental health training. Training trusted community members was a necessity. The context also meant that providers and participants shared quite recent and similar experiences. Participants were very motivated to receive help, and likely their expectations were heightened by the urgency of their need. The match between provider-community members and participant-community members is akin to therapist/client matching, which provides a preordained congruence in the relationship. This supports the common factor of relationship and expectations of help. Wampold (Reference Wampold2015) explores how empathic communication is central to establishing the relationship.

Cuipers et al. (Reference Cuipers, Reijnders and Marcus2019) take exception to the conclusion that common factors are involved in why different interventions have comparable outcomes, pointing out that not all studies demonstrate this finding. To resolve these differences, multiple, very large (for power) and complicated experimental studies must be carried out to systematically look at different process variables involved in outcomes.

Regardless, Cuipers is identifying meta-analyses that involved what are called “bona fide” treatments of greater duration than our interventions. In our case, 2- to 3-day workshops may be more likely to involve the common elements because of the context (relief from ongoing violence) and the level of need for relief from psychological distress. As such, there may be great hope and optimism for being attended to, being acknowledged for their suffering and sharing with others in their community so that the commonality of experience is relieving.

Yeomans et al. (Reference Yeomans, Forman, Herbert and Yuen2010) provide further evidence of process components in HROC. Their study administered HROC under two conditions against a waitlist control group. Groups attended HROC that included psychoeducation about post-traumatic stress and another version of HROC that did not include psychoeducation about trauma. To make both HROC interventions equivalent in time, investigators added exercises devoted to social engagement. The exercises included pairing participants and having them answer or discuss questions provided to them. The exercise facilitated greater communication about trust, safety, sense of security and interethnic conflict. Discussion questions, such as “someone I trust and why” and “a time I overcame fear,” were used and the pairs were asked to share information about how interethnic conflict had impacted each of them. While both HROC groups experienced a reduction in symptoms as measured by the HSCL-25, the group that improved the most was the group with enhanced social engagement. The increased time devoted to enhancing the interpersonal relationship through dialogue benefited and reduced subjects’ distressing symptoms more than HROC with PTSD psychoeducation.

Whether the benefits observed were due to common factors or due to specific aspects of each intervention is a question that warrants additional evaluation and may guide future research. That said, the value of these interventions is clear, as illustrated by the comments of one study participant: “I called him ‘my brother’… He was surprised! Then I continued: ‘It would have been your end today if I had not been in a workshop and learned about the consequences of violence and steps leading to it. Come with me tomorrow morning and attend the last day of the workshop: you will understand that you were wrong being in a militia killing people.’” There were also requests from militia leaders for their children to experience PVE treatment, even though they themselves would not. They felt they were caught up in the hostilities but hoped for a better life for their children.

Returning to the combined workshop groups compared to the waitlist controls, the two intervention groups yielded similar results. Therefore, they were combined for analysis and compared to the waitlist control group. These two groups – intervention and control – started with a similar symptomology (depression, anxiety and trauma), but the intervention group experienced a significant decline in symptoms compared to the control group. The control group also reported a gradual decline in symptoms, but the intervention group experienced significantly fewer symptoms than the control group. The gradual improvement of the control group was not anticipated but might be due to several factors. We consider two possible explanations for this finding: first, if there is a reduction in conflict, then lives stabilize and emotional distress returns to baseline levels. At the time of this study, there were UN peacekeeping troops on the ground that served to reduce the level of conflict. At the same time, the research team heard gunfire twice during the study, and they were not allowed to go outside of Bangui because it was judged too dangerous. This instability is reflected in an overview of the conflict (International Peace Information Service, 2018). Another possible explanation for these outcomes is that the repeated interviews in and of themselves acted as an intervention since individuals on the waitlist were given the opportunity to share their experiences. Similar waitlist control effects were observed in Patterson et al. (Reference Patterson, Boyle, Kivlenieks and Van Ameringen2016). In future studies, it may be prudent to add additional waitlist control groups with fewer interviews.

Since this study was conducted, more advancements have occurred in the Global Mental Health field. Systematized training and monitoring paradigms have been developed to train community-based or nonspecialist health workers. The WHO has developed manualized interventional training on various mental health topics (WHO, n.d.). The Ensuring Quality in Psychological Support is a joint WHO and UNICEF online training tool that includes all e-learning courses and competency assessment tools for scaling up community health workers in the key areas of depression and anxiety (Kohrt et al., Reference Kohrt, Pedersen, Schafer, Carswell, Rupp, Jordans, West, Akellot, Collins, Contreras, Galea, Gebrekristos, Mathai, Metz, Morina, Mwenge, Steen, Willhoite, van Ommeren and Underhill2024). In addition, a more sophisticated strategy for demonstrating training and adherence to common elements practices in psychosocial healing has been demonstrated with the enhancing assessment of common therapeutic factors (Kohrt et al., Reference Kohrt, Jordans, Rai, Shrestha, Luitel, Ramaiya, Singla and Patel2015). Similarly, the Common Element Treatment Approach (CETA) methodology developed by Murray et al. (Reference Murray, Dorsey, Haroz, Lee, Alsiary, Haydary, Weiss and Bolton2014) requires supervision by mental health professionals of trained laypeople. However, these more recent advancements presuppose infrastructure, personnel and trainers that do not exist in CAR.

It should be noted that a distinction must be made between different dimensions in the implementation of interventions. That is, is it early/later in the cessation of conflict/disaster, what is the infrastructure and what personnel are available and is the intervention community-based or individually based? The Interagency Standing Committee on Mental Health and Psychosocial Support identifies a continuum of service delivery (IASC, 2006). This parallels the development of interventions across time in the literature. Generally speaking, post-conflict results in degradation of infrastructure. Preexisting conditions in the country relate to what personnel may be mobilized. In the CAR, there was a paucity of infrastructure as well as almost nonexistent personnel. As such, immediate community-based interventions were carried out. Our study focuses on brief psychosocial interventions early in recovery. Targeting regionally based training could enhance service provision so that both sustainability and interventions could move beyond the immediate capital area.

A limitation to the generalizability and replicability of this study in other settings is that community partnerships were critical to our ability to bring together formerly warring groups, who were essential to this study. Without their cooperation and support, the study could not have happened. In addition, this study may only be sustainable with funding from NGOs and other donors. Although the study is of low cost and involves laypeople, significant sustainability issues exist. Providing the training is dependent on funding and psychologically minded NGOs. In-country trainers may come from around the country, so transportation and lodging costs must be covered. Meeting rooms must be rented, travel costs for participants must be reimbursed and food and drink need to be provided. Ongoing training and support for the trainers are essential as well, as this is taxing work.

Sustainability may also be addressed by looking to literature on digital interventions using computer technology. For example, both individual and group interventions have been shown to improve depression, maternal/infant health, smoking cessation and other mental health disorders (Muñoz et al., Reference Muñoz, Chavira, Himle, Koerner, Muroff, Reynolds, Rose, Ruzek, Teachman and Schueller2018). Unfortunately, access to telecommunications in CAR is both expensive and the infrastructure is lacking (International Telecommunication Union, 2023). When it does become practically available, one of the important questions to ask will be whether advances in communication impact the outcomes found in this study.

Another limitation is related to the feasibility of such a study in the context of ongoing conflict. Beyond the preexisting challenges to mental health care in under-resourced communities, ongoing conflict presents a host of additional challenges to trauma healing. Studies on the efficacy of trauma treatment have found that interventions are less effective when those in treatment continue to be exposed to traumatic stress (Bass et al., Reference Bass, Annan, McIvor Murray, Kaysen, Griffiths, Cetinoglu, Wachter, Murray and Bolton2013). Moreover, when resources are scarce, it is often deemed unreasonable to pursue interventions aimed at trauma. A community in the throes of a conflict has more pressing needs related to the physical safety of the public, and this applies to the interventionists as well (Bolton et al., Reference Bolton, Bass, Betancourt, Speelman, Onyango, Clougherty, Neugebaeur, Murray and Verdeli2007). Nonetheless, group psychotherapy for the treatment of traumatic stress symptoms is still effective in communities that continue to experience traumatic events (Bass et al., Reference Bass, Annan, McIvor Murray, Kaysen, Griffiths, Cetinoglu, Wachter, Murray and Bolton2013; Resick and Monson, Reference Resick, Monson and Chard2024). The issue of ongoing conflict is certainly relevant to CAR. At the time of this study, the conflict had mostly stopped, and it seemed as though CAR was going into a relatively peaceful time. This turned out not to be sustained peace. However, it raises the question of whether this work could have been done amid conflict and whether warring factions could have been brought together in this way had there not been a sense of hope that they were entering a period of peace.

Conclusions

The findings from this study provide support for the practice of training and supporting local paraprofessionals in the implementation of short-term, culturally appropriate, evidence-based interventions. These findings suggest that these interventions can reduce symptoms related to anxiety, depression and traumatic stress symptoms in post-conflict settings. However, the longevity of these effects may depend on how stable the environment is and what other activities the participants engage in. It is imperative to continue assessing the impact of psychologically related interventions. Funding agencies understandably prioritize the emergency needs of the populations in crisis. Mental health needs are typically not addressed first, although they are crucial to getting the local economies functioning again and improving the lives of the affected citizens. Given that resources are often limited in post-conflict settings, it is important to maximize the usefulness of any mental health intervention. Understanding which mental health interventions work and which do not is vital. Further, even interventions (e.g., PVE), which were not expected to have an impact on mental health, turned out to be effective, which raises the very important question as to what the active elements are in the mental health interventions that work. The fact that some effective interventions can be delivered by paraprofessionals at low cost means that the help that once seemed unattainable is within reach.

Open peer review

To view the open peer review materials for this article, please visit http://doi.org/10.1017/gmh.2025.10015.

Data availability statement

Due to the sensitive nature of participant responses, data are not made available to the general public. Researchers can request the sharing of data from W.J.F.

Acknowledgments

The authors specially thank all members of the Catholic Relief Services staff, in particular Robert Groelsema, Driss Moumane, Ariana Proctor, Florence Ntakarutimana and Olive Somse; Aegis staffs Freddy Mutanguha, Alain Lazaret, Lambert Kanamugire and Glen Ford; Echelle Translation Services staff Alain Serge Magbe and Dr. Lisa Brown of Palo Alto University. Natasha Greenberg of USAID believed in the project and helped get it funded. Dr. Chad Murchison provided expert statistical consultation.

Author contribution

Conceptualization: W.J.F., K.B.F., S.G.P.; Data curation: W.J.F.; Formal analysis: W.J.F.; Funding acquisition: K.B.F., Glen Ford (Aegis Trust), W.J.F.; Investigation: W.J.F.; Methodology: W.J.F.; Project administration: W.J.F., K.B.F.; Supervision: W.J.F., K.B.F.; Writing – original draft: W.J.F., M.V.Z., K.B.F., V.B., S.G.P.; Writing – review and editing: W.J.F., M.V.Z., K.B.F., V.B., S.G.P.

Financial support

The research project was funded directly by a contract to Palo Alto University from the Catholic Relief Services as part of a grant from USAID (USAID RFA-OAA-15-000017). A combination of funders provided necessary direct and indirect support and donations in kind. These organizations were USAID, Aegis Trust, Global Inter-Religious Alliance, Plateforme Des Confessions Religieuses de Centrafrique, Islamic Relief and World Vision. The Sea Grape Foundation provided important matching funds in the public/private funding of this project.

Competing interests

The authors declare no competing interests exist.

Ethics statement

This study was approved through the IRB at Palo Alto University. Informed consent was obtained from all participants, including information explaining that data would be anonymized to preserve the privacy of participants. Information was provided as to the rationale for the study and storage of data.

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Figure 0

Table 1. Comparison of HROC and PVE

Figure 1

Table 2. Sample-selection flow chart

Figure 2

Table 3. Self-reported traumatic events on a modified version of the Harvard Trauma Questionnaire

Figure 3

Table 4. Sex and religion

Figure 4

Figure 1. Results for three experimental groups by four assessments on mean HSCL-25 scores.

Figure 5

Figure 2. Combined workshop groups compared to the waitlist control group on mean HSCL-25 scores.

Figure 6

Figure 3. PCL-5 mean scores for combined treatment groups and waitlist control group.

Author comment: RCT of post-conflict trauma interventions in the Central African Republic — R0/PR1

Comments

Judith Bass, Ph. D.

Editor

Cambridge Prisms: Global Mental Health

Dear Dr. Bass:

This cover letter is to accompany the manuscript we have attached. The work we did was in the Central African Republic. The first manuscript (Patel et al. 2020) was Phase 1 of the project and was a qualitative study where we sought to understand the cultural context of mental health in CAR, especially anxiety, depression and trauma. This manuscript is quantitative. We screened participants for high levels of anxiety/depression and then randomly assigned them to one of 3 group interventions run by local paraprofessionals. We wanted to investigate if the trauma focused intervention would reduce anxiety/depression and PTSD compared to the wait list control, which it did. The third group focused on the causes of genocide and ways to counter it. This group performed like the trauma intervention group—both were significantly more effective than the wait list control group. The fact that they performed the same suggests that their impact is due to common factors.

This study provides important information in several ways:

1. The RCT component allows us to make causal statements about the impact of the interventions. Prior work with these measures gathered pre and posttest data but didn’t employ any control groups

2. The study shows that task shifting can extend the impact of mental health professionals, something that is critically important in a place like CAR where there are few if any mental health professionals.

3. The similar impact of the two interventions suggests that the first phase in the healing process is likely due to group processes after conflict has set people against each other. Informal reports from the participants expressed relief and eagerness to continue with similar experiences as it was starting to heal the conflict induced psychological wounds.

We look forward to the reviewers’ feedback.

Sincerely,

William J. Froming, Ph.D.

Review: RCT of post-conflict trauma interventions in the Central African Republic — R0/PR2

Conflict of interest statement

Reviewer declares none.

Comments

The article makes some important points and presents useful analyses in terms of what works in humanitarian and crisis settings. Its also points out very important arguments regarding sustainability, significance of contextually informed interventions, and dependence on outside NGOs. Some suggestions for improving the manuscript:

Overall, the flow of the article is a bit hard to follow. some of the sections seem to be overlapping, or mismatched (eg results in methods, methods in results), and its hard to understand how the authors get to their conclusions in the discussion given the lack of attention to common factors and process elements in the intro and methods. Some other specific feedback:

1. clean up the aims to clarify what you are testing. Specifically, the wording for the sentence starting on line 190, “if both HROC and PVE produce similar positive results, then the common elements of the two…” —common elements have not been introduced, and this is an assumption. I would be specific in defining what common elements (or factors) are. Additionally, it’s not clear how or whether the group vs individual focus of the interventions is assessed as a component for symptom change, and additionally, it’s not clear about what skill sets of the workshop facilitators have that could influence outcomes, and whether those are assessed or not.

2. add a table to show the differences in components for the two interventions, and consider describing the two interventions in the methods section.

3. methods - interviews are introduced but not explained, are they one-on-one, or qualitative? the assumption is that they are one-on-one to fill out surveys, this should be clarified.

--can you say more about the validity of the tools in general, as well as the impact of not having the tools translated but rather read out in one language or the other? how was the translation confirmed for the items, what process was used?

—please describe in more detail the consent and recruitment process, as well as the randomization (eg blinding or no blinding, who was it done by).

4. results - the first 3 sentences are methods and should be moved there. same for the exploratory methods on gender.

5. discussion — it’s unclear why the authors would jump to CETA besides the trauma module, there isn’t indication from participants that they would want or need further individualized TX, particularly as this study couldn’t differentiate between the group and individual-focused TX outcomes.

- the authors suggest that there are process elements and common factors that are the cause for the outcomes, which could be true, but the authors did not seem to present, code, or analyze distinct common factors or process elements. This would be a key next step (eg moderation or mediation analyses). Additionally, regarding contextual and cultural reflections as the authors mention a few times, it’d be a critical next step to interview qualitatively with the participants to determine what they find as the most impactful elements, or conduct something like a theory of change workshop, and again, whether more individualized focused trauma care is useful.

It’s confusing why so much description is given to CETA in the discussion, given the amount of time the authors highlight, in honesty, the lack of resources to sustain such a rigorously implemented form of care and highlight how impactful the two psychoeducation-based workshops are. It could be useful for the authors to consider other routes or options in the discussion, as well as to consider future steps in terms of answering what could work next, including further analyses on common factors, qualitative and stakeholder interviews, and potentially considering transitional justice reform or larger policy changes that are needed, including who and how these interventions are used. For instance, it would be great to hear the authors' thoughts on whether there are ways to sustain this delivery outside of psychologically-minded NGOs dropping in and leaving again, for instance via train-the-trainer models and reimagining traditional or colonialist-informed clinical supervision models, and whether trauma care is something different in this setting than the western clinical models currently dominating the world.

Review: RCT of post-conflict trauma interventions in the Central African Republic — R0/PR3

Conflict of interest statement

Reviewer declares none.

Comments

This is an interesting study and a contribution to the literature, particularly with regards to interventions in CAR. There are a number of areas where more detail is needed and the analytic plan needs to be revisited since the intervention was group based rather than individual. In addition, the finding that effects were not maintained over time requires more discussion. The results seem overstated, as the intervention was not more effective than waitlist control at follow-up.

Page 7, line 112: The authors note that the measures are “cross-culturally validated.” Please provide details about the validity testing of the HSCL, HTQ and PCL in CAR.

Page 8, line 135: The authors note that group composition should consist of both Christians and Muslims (both sides of the conflict). Did this occur? Please provide a demographics table of the whole sample and then for each of the 3 conditions. How many members of each of the groups were in each of the workshops?

Page 11 Participants:

- Please provide more details about who the religious leaders were and how and why they were selected to nominate individuals. Were the data derived from just a few religious communities? How many people were self-nominated and how did they hear about the study?

- Please provide a flow chart explaining the reduction in participants from 960 to 290.

- Were there any differences between the 260 who completed the program and those who did not?

- There appear to be more Christians (67%) than Muslims (27%). What are the implications for the intervention? What was the background of the facilitators?

Page 12 line 216: The authors note that transportation costs were paid to those who participated at the office or community space. Were any incentives provided for the assessments themselves? For the workshops?

Page 12, line 221: What was the translation process and who did the translations? How many participants completed the interview in Sango vs. French?

Page 12, Measures and Inclusion Criteria: Was the HSCL cut-off the only inclusion criteria? Why was the HSCL used and not the PCL if the primary outcome was PTSD symptoms? Were there any exclusion criteria? How was the cut-off score determined? Line 234: “a subset was scheduled and could participate as required.” Why just a subset? How was this subset selected?

Page 13 line 238: Please provide the N sizes and not just the percents. A table of trauma events would be helpful.

Page 13, line 248: The authors state “the proposed study was discussed with a psychology professor at the University of Bangui.” What does this mean? What happened in the discussion? what was the purpose and outcome of the discussion? Was the professor involved?

Page 13 line 250: In what ways was the Consortium of Interfaith Peacebuilding Platform involved in the study?

Study Design:

- Who led the groups/workshops? what was their training and supervision? How were they selected?

- Provide more detail about the workshops. Where were they conducted? How long were they? Were participants compensated for participating in or traveling to the workshops?

- Who were the assessors? were they blind to participant condition?

- How was randomization done?

- How many workshops were conducted and how many people were in each group?

- This was a group-based treatment and so analyses should be conducted at the group level rather than the individual level. Multi-level models?

- Were the same participants together in each group, i.e., if they completed HROC first were they with the same people to complete the PVE?

Results

- Line 264: Was the final sample 290 or 253? Was the analysis only based on the complete cases? Why not use an intent-to-treat approach? Were there differences between those who dropped out and those who completed?

- Line 268: “the subject’s sex was not involved in any significant interactions” What does this mean? If sex predicted the primary outcome then it makes sense to include it as a covariate

Discussion

- Line 371: “Examples of this may be found in the comments of workshop participants, which clearly distinguished which workshop a participant attended.” What comments of workshop participants? to the assessors? If so, then were the assessors actually blind to condition?

- Line 427: who were the “key stakeholders and community partners” and what was their involvement?

- Line 431: Who were the in-country trainers and what was their involvement?

- More needs to be said about the fact that differences were not observed between the waitlist condition and the intervention condition at 3 months. In what ways does this reduce enthusiasm for the interventions or not?

Figure 1

- In the legend, list the interventions as the combined HROC/PVE and PVE/HROC

- add 95% CI to the graph

Recommendation: RCT of post-conflict trauma interventions in the Central African Republic — R0/PR4

Comments

No accompanying comment.

Decision: RCT of post-conflict trauma interventions in the Central African Republic — R0/PR5

Comments

No accompanying comment.

Author comment: RCT of post-conflict trauma interventions in the Central African Republic — R1/PR6

Comments

Victoria Lane

Editorial Office, Cambridge Prisms: Global Mental Health

Dear Victoria,

Thanks again for your time extension on our manuscript. I have posted the clean revision and the “track changes” version to the website. I have also included an Excel spreadsheet (in the supplemental materials section) that compiles the comments of the reviewers and our responses to them. Those comments are typically in this letter, but we worked off of the Excel file and it is straightforward. It should make it clear how we responded to the editorial comments.

There are two tables and three figures for the manuscript. I cut two tables detailing the participants’ characteristics. They had been suggested by the reviewers. I covered the information in the text. However, the 5 tables/figures maximum meant something had to be eliminated and I chose those two. If there is flexibility in the rule, I can restore them.

If there is anything I have overlooked, please let me know.

Many thanks,

Bill Froming

Review: RCT of post-conflict trauma interventions in the Central African Republic — R1/PR7

Conflict of interest statement

Reviewer declares none.

Comments

Thanks to the authors for the revisions. This work remains imporant and it is clear that the authors implementing the interventions are quite knowledged about the processes and their impact.

The authors’ edits have improved the article as a whole, including adding more tables and descriptions to support the overall goals of the article. However, a few comments go unaddressed and the article could benefit from further revision, particularly to clarify the approach in formulating the hypothesis and goals of the research, and connecting to recent, relevant global work.

A few specific comments:

1.The authors must elaborate on the common elements argument via existing evidence, ideally both in the intro or the discussion. For instance, the common factors has empirical evidence and huge impact to the field over the last 10 years, especially the last 6 (e.g., ENACT tool, “EQUIP”, reviews by Singla et al, Wampold et al, Cuijpers et al, and other researchers in the common factors field). It’s unclear why the authors do not delve into this argument, as was suggested in one of the reviewers’ comments, as it would support the research study more strongly. I suggest the authors consider strengthening their argument about common factors as effective components by citing relevant literature from the field to bolster their hypothesis and goal of the research itself.

2. similarly, the argument that the two interventions are uniquely different via its trauma-focus remains slightly undermined by how the authors compare and describe the two. under the present study, the authors outline that PVE isn’t intended to improve MH outcomes thus allowing it to act as an “active control.“ However, going through the article, it seems perhaps the difference is simply in how mental health or trauma is framed when the intervention was developed, leaving questions as to whether PVE is doing trauma-informed work but without the Westernized lens? For instance, when authors describe PVE, they lay out that it uses mental health techniques, ”cognitive and behavioral skills “, and the outcome “to engage in positive activities in the future”. The comparison table shows that PVE uses common factors, or training in mental health foundational helping skills, such as empathy & active listening . Additionally, in the section ”comparing interventions", HVOC is described as different because it discusses history and concept of collective trauma for the individual versus PVE focusing on a genocide (a collective traumatic event) and discussing shared histories of cycles of violence such as colonialism. How are these components uniquely different? Both are group-based. And both seem to offer coping skills based on the authors’ descriptions. As such, the authors could clarify what they mean by not being different since one is not “trauma-focused”. For instance, describing what it means to for interventions or psychosocial support to be trauma-focused, and how one would know it wasn’t, especially given the group-based context.

3. the table comparing interventions needs clearer column and row headings

4. suggest to add numeric psychometric properties such as internal consistency, construct validity, and validated cut-offs for the measures.

5. similar to the intro, the discussion writes about common factors but does not include any recent (the last 1-3 yrs) citations. Given common factors is evidenced so widely in the field, the article could be improved by linking to empirical research in more depth, such as providing explicit examples of how it’s been identified as effective when compared to tx specific elements, and how much attention has been given in the last 6 years alone on concretely training non-specialists and specialist alike, (particularly in humanitarian settings), in these skills and group-facilitation skills.

6. The authors do not aptly elaborate in the discussion as to why a more intensive, individualized, resource-heavy trauma intervention, like CETA, is the appropriate next step whilst they accurately describe the context as "significant sustainability issues exist. Providing the training is dependent on psychologically minded NGOs. In-country trainers may come from around the country, so transportation and lodging costs must be covered. Meeting rooms must be rented and food and drink need to be provided. Ongoing training and support is essential as this is taxing work.

Another limitation is related to the feasibility of such a study in the context of ongoing conflict. Beyond the pre-existing challenges to mental health care in under-resourced communities, ongoing conflict presents a host of additional challenges to trauma healing.”

The nod to group psychotherapy is useful, but also lends the question as to why a group-based psychotherapy intervention wouldn’t be the logical next step vs an individual-based trauma therapy like CETA.

7. Overall, the original supposition of the article, that common elements/factors are important and, trauma-focused or not, the intervention helps folks because of common elements/factors, remains unclear since it was not analyzed specifically for this study. It would be ideal to discuss other critical next steps, such as more in-depth quant or qual analysis into the impactful and effective components of each intervention.

Review: RCT of post-conflict trauma interventions in the Central African Republic — R1/PR8

Conflict of interest statement

Reviewer declares none.

Comments

I thank the authors for their attention to addressing the reviewer comments. There are still some areas that I recommend be improved prior to publication:

1. The details of the sample are a bit conflicting:

- One abstract says 298 participants, the other says 290.

- In the methods it says “The initial pool of participants was 960 adults who lived in Bangui” and then later it says “The initial testing involved 1103 individuals. The first set of participants (N = 143) were used as pilot subjects for the assessors in order to clear up any questions about testing procedures and meaning of the questions. The formal testing was then conducted on 960 participants.” I suggest starting with the 1103 and then explaining how you reduce down to 960. Why was the sample size of 143 selected?

- Why were only 450 participants called out of the 502 who met the HSCL cutoff of 1.75? What happened to the other 52 people?

- Sometimes the authors state that 650 people met the HSCL but off, and other times it says that 502 met the cut-off. Which is correct? Please provide a participant flowchart starting with the 1103 and ending with the 290 indicating how many participants dropped out or were removed from the study at each step.

2. The mechanisms underlying the two interventions are still not well-fleshed out. The HROC intervention is defined as having a “trauma-focus” but the outcome is anxiety and depression symptoms. Please describe the mechanisms of the HROC intervention that are theorized to be the “active ingredients” of anxiety and depression symptoms and why these factors are not theorized to be present in the PVE intervention.

3. At a few points the HSCL is referred to as HSRC. Please correct and spell out HSCL the first time it used.

4. The authors state “The final number of participants was 290, defined as people who participated in at least 3 of the 4 assessment sessions.” How many participants participated in each workshop and each assessment session?

5. Were there any differences in the key variables and demographics of those who were initially screened, those who met inclusion criteria but did not complete the sessions, and those who completed the full study and were included in the final sample of 290 participants?

6. Why were participants not scheduled for the next assessment if they missed the preceding workshop? This process does not align with best practices of an intent-to-treat approach.

7. The decision to use and anxiety/depression measure (the HSCL-25) as the screening criteria for a PTSD intervention is still unclear. There is no literature cited to support the statement “however the HSCL-25 has been used more internationally and is easier to understand compared to the PCL-5.” In addition, the Barbano et al 2019 citation was not listed in the reference list so I could not check the cited reference that the HSCL “targets two major inherent components of PTSD.”

8. The justification for sample size of “we wanted to test as many subjects as possible” is not adequate. Please provide more information to justify the sample size.

9. The authors note “This study was part of a larger effort to de-escalate the violence gripping CAR. The CIPP was an interfaith group composed of Catholic Relief Services (CRS), Aegis Trust (AT), Islamic Relief Worldwide (IRW), and World Vision International (WVI). The function of the group included three major foci: 1. Civil Institutions Establish Leadership Role in Peacebuilding; 2. Livelihoods Security is Re-established; 3. Social Cohesion Fostered through HROC and PVE.” It is not clear what CIPP is or how these organizations interfaced with the study.

10. There are repeated and redundant sections throughout the manuscript.

Recommendation: RCT of post-conflict trauma interventions in the Central African Republic — R1/PR9

Comments

Dear Dr. Froming,

Thank you for submitting the revised manuscript entitled “RCT of Post-Conflict Trauma Interventions in the Central African Republic” to Cambridge Prisms: Global Mental Health. We appreciate the effort you have put into addressing the comments from the previous round of reviews. After a careful re-evaluation of the revised manuscript, we would like to offer the following additional feedback, which we hope will help guide you toward further enhancing the clarity and quality of your article.

The reviewers have provided detailed and constructive suggestions that we strongly encourage you to carefully consider. We recommend that you respond thoroughly to each of the reviewers' comments, providing justifications for any suggestions that you choose not to incorporate. If you do decide not to implement specific feedback, please explain why this decision was made, ensuring that your response reflects a thoughtful and evidence-based approach.

Reviewer 1:

Thanks to the authors for the revisions. This work remains imporant and it is clear that the authors implementing the interventions are quite knowledged about the processes and their impact.

The authors’ edits have improved the article as a whole, including adding more tables and descriptions to support the overall goals of the article. However, a few comments go unaddressed and the article could benefit from further revision, particularly to clarify the approach in formulating the hypothesis and goals of the research, and connecting to recent, relevant global work.

A few specific comments:

1.The authors must elaborate on the common elements argument via existing evidence, ideally both in the intro or the discussion. For instance, the common factors has empirical evidence and huge impact to the field over the last 10 years, especially the last 6 (e.g., ENACT tool, “EQUIP”, reviews by Singla et al, Wampold et al, Cuijpers et al, and other researchers in the common factors field). It’s unclear why the authors do not delve into this argument, as was suggested in one of the reviewers’ comments, as it would support the research study more strongly. I suggest the authors consider strengthening their argument about common factors as effective components by citing relevant literature from the field to bolster their hypothesis and goal of the research itself.

2. similarly, the argument that the two interventions are uniquely different via its trauma-focus remains slightly undermined by how the authors compare and describe the two. under the present study, the authors outline that PVE isn’t intended to improve MH outcomes thus allowing it to act as an “active control.“ However, going through the article, it seems perhaps the difference is simply in how mental health or trauma is framed when the intervention was developed, leaving questions as to whether PVE is doing trauma-informed work but without the Westernized lens? For instance, when authors describe PVE, they lay out that it uses mental health techniques, ”cognitive and behavioral skills “, and the outcome “to engage in positive activities in the future”. The comparison table shows that PVE uses common factors, or training in mental health foundational helping skills, such as empathy & active listening . Additionally, in the section ”comparing interventions", HVOC is described as different because it discusses history and concept of collective trauma for the individual versus PVE focusing on a genocide (a collective traumatic event) and discussing shared histories of cycles of violence such as colonialism. How are these components uniquely different? Both are group-based. And both seem to offer coping skills based on the authors’ descriptions. As such, the authors could clarify what they mean by not being different since one is not “trauma-focused”. For instance, describing what it means to for interventions or psychosocial support to be trauma-focused, and how one would know it wasn’t, especially given the group-based context.

3. the table comparing interventions needs clearer column and row headings

4. suggest to add numeric psychometric properties such as internal consistency, construct validity, and validated cut-offs for the measures.

5. similar to the intro, the discussion writes about common factors but does not include any recent (the last 1-3 yrs) citations. Given common factors is evidenced so widely in the field, the article could be improved by linking to empirical research in more depth, such as providing explicit examples of how it’s been identified as effective when compared to tx specific elements, and how much attention has been given in the last 6 years alone on concretely training non-specialists and specialist alike, (particularly in humanitarian settings), in these skills and group-facilitation skills.

6. The authors do not aptly elaborate in the discussion as to why a more intensive, individualized, resource-heavy trauma intervention, like CETA, is the appropriate next step whilst they accurately describe the context as "significant sustainability issues exist. Providing the training is dependent on psychologically minded NGOs. In-country trainers may come from around the country, so transportation and lodging costs must be covered. Meeting rooms must be rented and food and drink need to be provided. Ongoing training and support is essential as this is taxing work.

Another limitation is related to the feasibility of such a study in the context of ongoing conflict. Beyond the pre-existing challenges to mental health care in under-resourced communities, ongoing conflict presents a host of additional challenges to trauma healing.”

The nod to group psychotherapy is useful, but also lends the question as to why a group-based psychotherapy intervention wouldn’t be the logical next step vs an individual-based trauma therapy like CETA.

7. Overall, the original supposition of the article, that common elements/factors are important and, trauma-focused or not, the intervention helps folks because of common elements/factors, remains unclear since it was not analyzed specifically for this study. It would be ideal to discuss other critical next steps, such as more in-depth quant or qual analysis into the impactful and effective components of each intervention.  

Reviewer 2:

I thank the authors for their attention to addressing the reviewer comments. There are still some areas that I recommend be improved prior to publication:

1. The details of the sample are a bit conflicting:

- One abstract says 298 participants, the other says 290.

- In the methods it says “The initial pool of participants was 960 adults who lived in Bangui” and then later it says “The initial testing involved 1103 individuals. The first set of participants (N = 143) were used as pilot subjects for the assessors in order to clear up any questions about testing procedures and meaning of the questions. The formal testing was then conducted on 960 participants.” I suggest starting with the 1103 and then explaining how you reduce down to 960. Why was the sample size of 143 selected?

- Why were only 450 participants called out of the 502 who met the HSCL cutoff of 1.75? What happened to the other 52 people?

- Sometimes the authors state that 650 people met the HSCL but off, and other times it says that 502 met the cut-off. Which is correct? Please provide a participant flowchart starting with the 1103 and ending with the 290 indicating how many participants dropped out or were removed from the study at each step.

2. The mechanisms underlying the two interventions are still not well-fleshed out. The HROC intervention is defined as having a “trauma-focus” but the outcome is anxiety and depression symptoms. Please describe the mechanisms of the HROC intervention that are theorized to be the “active ingredients” of anxiety and depression symptoms and why these factors are not theorized to be present in the PVE intervention.

3. At a few points the HSCL is referred to as HSRC. Please correct and spell out HSCL the first time it used.

4. The authors state “The final number of participants was 290, defined as people who participated in at least 3 of the 4 assessment sessions.” How many participants participated in each workshop and each assessment session?

5. Were there any differences in the key variables and demographics of those who were initially screened, those who met inclusion criteria but did not complete the sessions, and those who completed the full study and were included in the final sample of 290 participants?

6. Why were participants not scheduled for the next assessment if they missed the preceding workshop? This process does not align with best practices of an intent-to-treat approach.

7. The decision to use and anxiety/depression measure (the HSCL-25) as the screening criteria for a PTSD intervention is still unclear. There is no literature cited to support the statement “however the HSCL-25 has been used more internationally and is easier to understand compared to the PCL-5.” In addition, the Barbano et al 2019 citation was not listed in the reference list so I could not check the cited reference that the HSCL “targets two major inherent components of PTSD.”

8. The justification for sample size of “we wanted to test as many subjects as possible” is not adequate. Please provide more information to justify the sample size.

9. The authors note “This study was part of a larger effort to de-escalate the violence gripping CAR. The CIPP was an interfaith group composed of Catholic Relief Services (CRS), Aegis Trust (AT), Islamic Relief Worldwide (IRW), and World Vision International (WVI). The function of the group included three major foci: 1. Civil Institutions Establish Leadership Role in Peacebuilding; 2. Livelihoods Security is Re-established; 3. Social Cohesion Fostered through HROC and PVE.” It is not clear what CIPP is or how these organizations interfaced with the study.

10. There are repeated and redundant sections throughout the manuscript.

Reviewer 1 has expressed concerns regarding the broader scientific goals of the manuscript, particularly around the conceptual framing of the hypothesis and the lack of engagement with recent research and broader perspectives in the discussion. Specifically, they noted that some critical comments regarding the article’s scientific goals were not adequately addressed, and that the manuscript could benefit from a more in-depth exploration of the future research directions in the field.

Additionally, Reviewer 1 highlighted the potential bias in the citation patterns, particularly in the discussion, where many of the recent references come from the same high-income country (HIC) institution. In this context, Reviewer 1 has suggested that the authors more explicitly engage with a wider range of sources, including from LMIC contexts, to avoid a narrow perspective and to foster equity in the framing of future research directions.

As editors, we are open to these important suggestions. We encourage the authors to consider how they might revise the manuscript to address Reviewer 1’s concerns by:

Expanding the discussion of the study’s scientific goals, particularly with regard to the field of global mental health and the role of common factors in interventions. This might involve incorporating more recent literature and clearer explanations of how this research fits into broader trends and gaps in the field.

Reassessing the citation patterns in the manuscript to ensure a broader and more equitable representation of research from both HIC and LMIC contexts. This would contribute to a more balanced perspective and address concerns about bias in the literature cited.

Considering ways in which future research in this area can better integrate ethical partnerships between HIC institutions and LMIC organizations, ensuring that research and publications reflect more equitable and inclusive collaborations.

We believe these revisions will help strengthen the manuscript and its relevance to a wider, global audience. We encourage the authors to engage thoughtfully with these suggestions, as doing so will not only enhance the article but also contribute to a richer, more diverse discourse in global mental health research.

We hope that this feedback is helpful as you move forward with revising your manuscript. If you have any questions or require further clarification regarding the reviewers' comments, please don’t hesitate to reach out. We look forward to receiving your revised manuscript and accompanying responses to the reviewers.

Best regards,

Sara Romero

Decision: RCT of post-conflict trauma interventions in the Central African Republic — R1/PR10

Comments

No accompanying comment.

Author comment: RCT of post-conflict trauma interventions in the Central African Republic — R2/PR11

Comments

Dear Dr. Romero,

Thank you for the thoughtful review of our manuscript entitled “RCT of Post-Conflict Trauma Interventions in the Central African Republic”, which we submitted for consideration to Cambridge Prisms: Global Mental Health (GMH-2024-0121.R1). We are pleased to learn that the reviewers recommend publication of the manuscript. We also understand that they suggest some remaining revisions, which we have now completed.

We carefully considered and addressed each comment from you and the two reviewers. All substantive changes within the body of the manuscript are highlighted in yellow. Our responses to each individual comment, with specific manuscript changes noted, as well as any associated page numbers, are listed below.

Thank you again for taking the time to review this manuscript. We welcome your response, and any continued suggestions for revisions. We believe that this study makes an important contribution to the field: a controlled trial of a trauma intervention within a conflict setting with limited or no mental health infrastructure. Thus, this paper provides a suggested pathway toward supporting the mental health of the world’s most vulnerable populations living in contexts of humanitarian crisis.

Many thanks,

William J. Froming, Ph. D.

Review: RCT of post-conflict trauma interventions in the Central African Republic — R2/PR12

Conflict of interest statement

Reviewer declares none.

Comments

The authors have addressed my comments.

Recommendation: RCT of post-conflict trauma interventions in the Central African Republic — R2/PR13

Comments

No accompanying comment.

Decision: RCT of post-conflict trauma interventions in the Central African Republic — R2/PR14

Comments

No accompanying comment.