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Exeporfinium chloride (XF-73) nasal gel significantly reduces Staphylococcus aureus nasal carriage in cardiac surgery patients throughout surgery and the early recovery period: results from a randomized placebo-controlled Phase 2 study

Published online by Cambridge University Press:  10 October 2024

Julie E. Mangino ,
Michael S. Firstenberg Open the ORCID record for Michael S. Firstenberg [Opens in a new window] ,
William Rhys-Williams Open the ORCID record for William Rhys-Williams [Opens in a new window] ,
James P. Lees ,
Aaron Dane ,
William G. Love ,
Jesus Gonzalez Moreno ,
Yuri Martina  and
Debra Barker Open the ORCID record for Debra Barker [Opens in a new window]
Julie E. Mangino
Affiliation:
Division of Infection Diseases, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
Michael S. Firstenberg
Affiliation:
Department of Surgery, Maui Memorial Medical Center, Maui, HI, USA
William Rhys-Williams*
Affiliation:
Destiny Pharma plc, Brighton, UK
James P. Lees
Affiliation:
Formerly at Destiny Pharma plc, Brighton, UK
Aaron Dane
Affiliation:
Danestat Consulting Ltd., Macclesfield, UK
William G. Love
Affiliation:
Destiny Pharma plc, Brighton, UK
Jesus Gonzalez Moreno
Affiliation:
Formerly at Destiny Pharma plc, Brighton, UK
Yuri Martina
Affiliation:
Formerly at Destiny Pharma plc, Brighton, UK
Debra Barker
Affiliation:
Destiny Pharma plc, Brighton, UK
*
Corresponding author: William Rhys-Williams; Email: wrw@destinypharma.com
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Abstract

Staphylococcus aureus nasal carriers were randomized (1:1) to XF-73 or placebo nasal gel, administered 5x over ∼24hrs pre-cardiac surgery. S. aureus burden rapidly decreased after 2 doses (–2.2log10 CFU/mL; placebo –0.01log10 CFU/mL) and was maintained to 6 days post-surgery. Among XF-73 patients, 46.5% received post-operative anti-staphylococcal antibiotics versus 70% in placebo (P = 0.045).

Information

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 45 , Issue 11 , November 2024 , pp. 1355 - 1357
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Copyright
© Destiny Pharma Limited, 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

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