Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-10-31T23:15:59.618Z Has data issue: false hasContentIssue false

Risk Factors for Methicillin-Resistant Staphylococcus aureus Surgical Site Infection

Published online by Cambridge University Press:  02 January 2015

Stephan Harbarth*
Affiliation:
Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
Benedikt Huttner
Affiliation:
Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
Pascal Gervaz
Affiliation:
Department of Surgery, University of Geneva Hospitals and Medical School, Geneva, Switzerland
Carolina Fankhauser
Affiliation:
Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
Marie-Noelle Chraiti
Affiliation:
Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
Jacques Schrenzel
Affiliation:
Microbiology Laboratory, University of Geneva Hospitals and Medical School, Geneva, Switzerland
Marc Licker
Affiliation:
Department of Anesthesiology, Pharmacology and Intensive Care, University of Geneva Hospitals and Medical School, Geneva, Switzerland
Didier Pittet
Affiliation:
Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
*
Infection Control Program, University of Geneva Hospitals and Medical School, 24, rue Micheli-du-Crest, 1211 Geneva 14 - , Switzerland (stephan.harbarth@hcuge.ch)

Abstract

We prospectively evaluated 46 possible risk factors for methicillin-resistant Staphylococcus aureus (MRSA) surgical site infection (SSI) among patients with MRSA carriage in a large intervention study. Of 6,130 study patients, 68 (1.1%) developed MRSA SSI, which occurred a median of 14 days after surgery. Risk factors associated with MRSA SSI were receipt of emergency surgery, presence of comorbid condition, receipt of immunosuppressive therapy, receipt of contaminated surgery, and a surgical duration longer than the 75th percentile. MRSA carriage on admission did not predict MRSA SSI.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Davis, KA, Stewart, JJ, Crouch, HK, Florez, CE, Hospenthal, D. Methicillin-resistant Staphylococcus aureus (MRSA) nares colonization at hospital admission and its effect on subsequent MRSA infection. Clin Infect Dis 2004;39:776782.CrossRefGoogle ScholarPubMed
2.Morange-Saussier, V, Giraudeau, B, van der Mee, N, Lermusiaux, P, Quentin, R. Nasal carriage of methicillin-resistant Staphylococcus aureus in vascular surgery. Ann Vase Surg 2006;20:767772.Google Scholar
3.Manian, FA, Meyer, PL, Setzer, J, Senkel, D. Surgical site infections associated with methicillin-resistant Staphylococcus aureus: do postoperative factors play a role? Clin Infect Dis 2003;36:863868.CrossRefGoogle ScholarPubMed
4.Harbarth, S, Fankhauser, C, Schrenzel, J, et al.Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 2008;299:11491157.Google Scholar
5.Mangram, AJ, Horan, TC, Pearson, ML, Silver, LC, Jarvis, WR. Guideline for prevention of surgical site infection, 1999. Infect Control Hosp Epidemiol 1999;20:250278.CrossRefGoogle ScholarPubMed
6.Anderson, DJ, Sexton, DJ, Kanafani, ZA, Auten, G, Kaye, KS. Severe surgical site infection in community hospitals: epidemiology, key procedures, and the changing prevalence of methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 2007;28:10471053.CrossRefGoogle ScholarPubMed
7.Engemann, JJ, Carmeli, Y, Cosgrove, SE, et al.Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis 2003;36:592598.CrossRefGoogle ScholarPubMed
8.Marshall, C, Wolfe, R, Kossmann, T, Wesselingh, S, Harrington, G, Spelman, D. Risk factors for acquisition of methicillin-resistant Staphylococcus aureus (MRSA) by trauma patients in the intensive care unit. J Hosp Infect 2004;57:245252.CrossRefGoogle ScholarPubMed
9.Shams, WE, Rapp, RP. Methicillin-resistant staphylococcal infections: an important consideration for orthopedic surgeons. Orthopedics 2004;27:565568.CrossRefGoogle ScholarPubMed
10.San Juan, R, Chaves, F, Lopez Gude, MJ, et al.Staphylococcus aureus post-sternotomy mediastinitis: description of two distinct acquisition pathways with different potential preventive approaches. J Thorac Cardiovasc Surg 2007;134:670676.Google Scholar