Hostname: page-component-7dd5485656-bvgqh Total loading time: 0 Render date: 2025-10-30T00:43:18.881Z Has data issue: false hasContentIssue false
  • English
  • Français

Timing of Intravenous Administration Set Changes: A Systematic Review

Published online by Cambridge University Press:  02 January 2015

Donna Gillies ,
Libba O'Riordan ,
Margaret Wallen ,
Karen Rankin ,
Anne Morrison  and
Sue Nagy
Donna Gillies*
Affiliation:
The Research Development Unit, The School of Nursing, Family and Community Health, The University of Western Sydney, New South Wales, Australia
Libba O'Riordan
Affiliation:
Oncology Department, The University of Technology, Sydney, New South Wales, Australia
Margaret Wallen
Affiliation:
Research Department, The University of Technology, Sydney, New South Wales, Australia
Karen Rankin
Affiliation:
Nursing Liaison Department, The University of Technology, Sydney, New South Wales, Australia
Anne Morrison
Affiliation:
Paediatric Intensive Care Unit, The Children's Hospital at Westmead, The University of Technology, Sydney, New South Wales, Australia
Sue Nagy
Affiliation:
Faculty of Nursing, Midwifery, and Health, The University of Technology, Sydney, New South Wales, Australia School of Nursing, Family and Community Health, University of Western Sydney, New South Wales, Australia
*
The Research Development Unit, The School of Nursing, Family and Community Health, The University of Western Sydney, Locked Bag 1797, Penrith South DC, NSW 1797, Australia
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To determine the optimal time interval for the routine replacement of intravenous administration sets when crystalloids or parenteral nutrition are administered via a central or peripheral catheter in an acute care setting.

Design:

Systematic review of all randomized or systematically allocated controlled trials addressing the frequency of replacing intravenous administration sets.

Methods:

The Cochrane Controlled Trials Register (June 2001) and the Ovid databases (Medline, CINAHL, and CancerLit-July 2001) were searched. Bibliographies, relevant conference proceedings, and any product information were also checked for references.

Results:

Eighteen studies were selected for review. The 12 included studies were separated into 3 intravenous administration set change comparisons; 24 hours versus 48 hours or more; 48 hours versus 72 hours or more; and 72 hours versus 96 hours or more. There was good evidence that changing intravenous administration sets every 72 hours or more does not increase the risk of infusate-related bloodstream infection (BSI) in patients with central or peripheral catheters and a fair level of evidence that it does not increase the risk of catheter-related BSI. There were insufficient data regarding the incidence of BSI among patients receiving parenteral nutrition, particularly lipid-containing parenteral nutrition.

Conclusions:

It appears that intravenous administration sets containing crystalloids can be changed in patients with central or peripheral catheters every 72 hours or more without increasing the risk of BSI. However, it is not possible to conclude that intravenous administration sets containing parenteral nutrition, particularly lipid-containing parenteral nutrition, can be changed at this interval.

Information

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 25 , Issue 3 , March 2004 , pp. 240 - 250
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1.Centers for Disease Control and Prevention. Guidelines for prevention of intravascular catheter-related infections. MMWR 2002;51(RR-10):1–29.Google Scholar
2.Mermel, LA, Farr, BM, Sherertz, PJ, et al. Guidelines for the management of intravascular catheter-related infections. Infect Control Hosp Epidemiol 2001;22:222–242.Google Scholar
3.Melly, MA, Meng, HC, Schaffner, W. Microbiol growth in lipid emulsions used in parenteral nutrition. Arch Surg 1975;110:1479–1481.CrossRefGoogle ScholarPubMed
4.Scott, EM, Gorman, SP, Wyatt, TD, Magill, EA. Growth of microorganisms in total parenteral nutrition mixtures and related clinical observation. Journal of Clinical and Hospital Pharmacy 1985;10:79–88.Google Scholar
5.Gilbert, M, Gallagher, SC, Eads, M, Elmore, ME. Microbial growth patterns in total parenteral nutrition formulation containing lipid emulsion. JPEN J Parenter Enteral Nutr 1986;10:494–497.CrossRefGoogle ScholarPubMed
6.Maki, DG, Botticelli, JT, LeRoy, ML, Thielke, TS. Prospective study of replacing administration sets for intravenous therapy at 48- vs 72-hour intervals: 72 hours is safe and cost-effective. JAMA 1987:258:1777–1781.Google Scholar
7.Snydman, DR, Donnelly-Reidy, M, Perry, LK, Martin, WJ. Intravenous tubing containing burettes can be safely changed at 72-hour intervals. Infect Control 1987;8:113–116.CrossRefGoogle ScholarPubMed
8.Jakobsen, CJ, Grabe, N, Nielsen, E, et al. Contamination of intravenous infusion systems: the effect of changing administration sets. J Hosp Infect 1986;8:217–223.Google Scholar
9.Sitges-Serra, A, Linares, J, Perez, JL, Jaurrieta, E, Lorente, L. A randomized trial on the effect of tubing changes on hub colonization and catheter sepsis during parenteral nutrition. JPEN J Parenter Enteral Nutr 1985;9:322–325.CrossRefGoogle ScholarPubMed
10.Robertson, J. Changing central venous catheter lines: evaluation of a modification to clinical practice. J Pediatr Oncol Nurs 1991;8:173–179.Google Scholar
11.Band, JD, Maki, DG. Safety of changing intravenous delivery systems at longer than 24-hour intervals. Ann Intern Med 1979;91:173–178.Google Scholar
12.Cohen, DM. A replication study: analysis of bacterial colonization of intravenous administration sets in use for 72 hours. Journal of the New York State Nurses Association 1989;20:12.Google Scholar
13.Robathan, G, Woodger, S, Merante, D. A prospective study evaluating the effects of extending total parenteral nutrition line changes to 72 hours. Journal of Intravenous Nursing 1995;18:84–87.Google ScholarPubMed
14.Powell, CR, Traetow, MJ, Fabri, PJ, Kudsk, KA, Ruberg, RL. Op-Site dressing study: a prospective randomized study evaluating povidone iodine ointment and extension set changes with 7-day Op-Site dressings applied to total parenteral nutrition subclavian sites. JPEN J Parenter Enteral Nutr 1985;9:443–446.Google Scholar
15.Raad, I, Hanna, H, Richardson, D, et al. Optimal frequency of changing intravenous administration sets (IVAS): is it safe to prolong duration of use beyond three days? Infect Control Hosp Epidemiol 1998;19:S682.Google Scholar
16.Raad, I, Hanna, HA, Awad, A, et al. Optimal frequency of changing intravenous administration sets: is it safe to prolong use beyond 72 hours? Infect Control Hosp Epidemiol 2001;22:136–139.CrossRefGoogle Scholar
17.Fox, M, Molesky, M, Van Aerde, JE, Muttitt, S. Changing parenteral nutrition administration sets every 24 h versus every 48 h in newborn infants. Can J Gastroenterol 1999;13:147–151.CrossRefGoogle Scholar
18.Matlow, AG, Kitai, I, Kirpalani, H, et al. A randomized trial of 72 versus 24 hour intravenous tubing set changes in newborns receiving lipid therapy. Infect Control Hosp Epidemiol 1999;20:487–493.CrossRefGoogle ScholarPubMed
19.Blight, I, Amadio, J, Thomas, P, Wilkinson, I, Lusis, I. Randomised Prospective Study of Replacing Intravenous Administration Sets at 72 Hours Versus 120 Hour Intervals in Central Venous Catheters: 4th Nursing Practice Conference Book of Abstracts. Adelaide: Royal Adelaide Hospital Nurse's Education; 1998:3.Google Scholar
20.DeMoissac, D, Jensen, L. Changing IV administration sets: is 48 versus 24 hours safe for neutropenic patients with cancer? Oncol Nurs Forum 1998;25:907–913.Google Scholar
21.Buxton, AE, Highsmith, AK, Garner, JS, et al. Contamination of intravenous infusion fluid: effects of changing administration sets. Ann Intern Med 1979;90:764–768.Google Scholar
22.Gorbea, HF, Snydman, DR, Delaney, A, Stockman, J, Martin, WJ. Intravenous tubing with burettes can be safely changed at 48-hour intervals1. JAMA 1984;251:2112–2115.Google Scholar
23.Josephson, A, Gombert, ME, Sierra, MF, Karanfil, LV, Tansino, GF. The relationship between intravenous fluid contamination and the frequency of tubing replacement. Infect Control 1985;6:367–370.CrossRefGoogle ScholarPubMed