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Antibiotic Resistance in ICUs: A Multifaceted Problem Requiring a Multifaceted Solution

Published online by Cambridge University Press:  02 January 2015

Robert Gaynes*
Affiliation:
Hospital Infections Program, National Centerfor Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
*
Chief Nosocomial Infections Surveillance Activity, Hospital Infections Program, Mailstop E55, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333
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Abstract

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Information

Type
Editorial
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1995 

References

1. Levy, SE. The Antibiotic Paradox. How Miracle Drugs Are Destroying the Miracle. New York, NY: Plenum Press; 1992.Google Scholar
2. Bryan, RT, Pinner, RW, Gaynes, RP Peters, CJ, Aguilar, JR, Berkelman, RL. Addressing emerging infectious disease threats: a prevention strategy for the United States. MMWR 1994;43(RR-5):118.Google Scholar
3. Tomasz, A. Multiple antibiotic resistant pathogenic bacteria. A report on the Rockefeller University workshop. N. Eng J Med 1994;330:12471251.Google Scholar
4. Billstein, SA. How the pharmaceutical industry brings an antibiotic drug to market in the United States. Antimicrob Agents Chmother 1994;38:26792682.Google Scholar
5. Coronado, VG. Edwards, JR, Culver, DH. Gaynes RP National Nosocomial Infections Surveillance system. Ciprofloxacin resistance among nosocomial Pseudomonas aeruginosa and Staphylococcus aureus in the United States. Infect Control Hosp Epidemiol 1995;16;7175.Google Scholar
6. Blumberg, HM, Rimland, D, Carroll, DJ, Terry, FP Wachsmuth, IK. Rapid development of ciprofloxacin resistance in methicillin-susceptible and resistant Staphylococcus aureus . J Infect Dis 1991;163:12791285.Google Scholar
7. Bryce, EA, Smith, JA Focused microbiological surveillance and gram-negative β-lactamase-mediated resistance in an intensive care unit. Infect Control Hosp Epidemiol 1995;16:331334.Google Scholar
8. Yu, VL, Oakes, CA, Axnick, KJ, Merigan, TC. Patient factors contributing to the emergence of gentamicin-resistant Serratia marcescens . Am J Med 1979;44:468473.Google Scholar
9. Weinstein, RA, Kabins, SA. Strategies for prevention and control of multiple drug-resistant nosocomial infection. Am J Med 1981;70:449452.Google Scholar
10. Centers for Disease Control and Prevention. Nosocomial enterococci resistant to vancomycin - United States, 1989-1993. MMWR 1993;42:597599.Google Scholar
11. Burwen, DR, Banerjee, SN, Gaynes, RP National Nosocomial Infections Surveillance system. Ceftazidime resistance among selected nosocomial gram-negative bacilli in the United States J Infect Dis 1994;170:16221625.Google Scholar
12. Gaynes, R, Culver, D, National Nosocomial Infections Surveillance (NNIS) system. Resistance to imipenem among selected gram-negative bacilli in the United States. Infect Control Hosp Epidemio1 1991;13:1014.Google Scholar
13. Weinstein, RA, Nathan, C, Gruensfelder, R, Kabins, SA. Endemic aminoglycoside resistance in gram-negative bacilli: epidemiology and mechanisms. J Infect Dis 1980;141:338342.Google Scholar
14. Centers for Disease Control and Prevention. Nosocomial infection rates for interhospital comparison: limitations and possible solutions. Infect Control Hosp Epidemiol 1991;12:609621.Google Scholar
15. McGowan, JE Jr. Do intensive hospital antibiotic control programs prevent the spread of antibiotic resistance? Infect Control Hosp Epidemiol 1994;15:478483.Google Scholar
16. Kritchevsky, SB, Simmons, BP Toward better antibiotic use in hospitals. Infect Control Hosp Epidemiol 1994;15:68&690.Google Scholar
17. McGowan, JE. Antibiotic-resistant bacteria and healthcare systems: four steps for effective response. Infect Control Hosp Epidemiol 1995;16:6770.Google Scholar
18. HICPAC. Recommendations for preventing the spread of vancomycin resistance. Infect Control Hosp Epidemiol 1995;16:105113.Google Scholar
19. Pallares, R, Dick, R, Wenzel, RP Adams, JR, Nettleman, MD. Trends in antimicrobial utilization at a tertiary teaching hospital during a 15-year period (19781992). Infect Control Hosp Epidemiol 1993;14:37&382.Google Scholar
20. Ballow, CH, Schentag, JJ. Trends in antibiotic utilization and bacterial resistance. Diagn Microbial Infect Dis 1992;15:37S42S.Google Scholar
21. Evans, RS, Larsen, RA, Burke, JP, et al. Computer surveillance of hospital-acquired infections and antibiotic use. JAMA 1986;256:10071011.Google Scholar