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Bacitracin Versus Mupirocin for Staphylococcus aureus Nasal Colonization

Published online by Cambridge University Press:  02 January 2015

Norberto E. Soto ,
Ashok Vaghjimal ,
Annette Stahl-Avicolli ,
John R. Protic ,
Larry I. Lutwick  and
Edward K. Chapnick
Norberto E. Soto*
Affiliation:
Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, New York
Ashok Vaghjimal
Affiliation:
Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, New York
Annette Stahl-Avicolli
Affiliation:
Department of Pharmacy, Maimonides Medical Center, Brooklyn, New York
John R. Protic
Affiliation:
Division of Microbiology, Department of Pathology, Maimonides Medical Center, Brooklyn, New York
Larry I. Lutwick
Affiliation:
Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, New York
Edward K. Chapnick
Affiliation:
Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, New York
*
Maimonides Medical Center, 4802 Tenth Ave, Brooklyn, NY 11219
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Abstract

We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed S aureus. After 72 to 96 hours of treatment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P=.0031). Similar efficacy was demonstrated at 30 days. Mupirocin may be more effective than bacitracin for eradication of S aureus in healthy HCWs.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 20 , Issue 5 , May 1999 , pp. 351 - 353
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1999

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