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Carbapenem-Resistant Enterobacteriaceae: A Strategic Roadmap for Infection Control

  • N. Deborah Friedman (a1), Yehuda Carmeli (a2) (a3) (a4), Aaron Lea Walton (a1) and Mitchell James Schwaber (a3) (a4)
  • Please note a correction has been issued for this article.

The incidence of carbapenem-resistant Enterobacteriaceae (CRE) has increased worldwide with great regional variability. Infections caused by these organisms are associated with crude mortality rates of up to 70%. The spread of CRE in healthcare settings is both an important medical problem and a major global public health threat. All countries are at risk of falling victim to the emergence of CRE; therefore, a preparedness plan is required to avoid the catastrophic natural course of this epidemic. Proactive and adequate preventive measures locally, regionally, and nationally are required to contain the spread of these bacteria. The keys to success in preventing the establishment of CRE endemicity in a region are early detection through targeted laboratory protocols and containment of spread through comprehensive infection control measures. This guideline provides a strategic roadmap for infection control measures based on the best available evidence and expert opinion, to enable preparation of a multifaceted preparedness plan to abort epidemics of CRE.

Infect Control Hosp Epidemiol 2017;38:580–594

Corresponding author
Address correspondence to A/Prof. N. Deborah Friedman, Departments of Medicine and Infectious Diseases, Barwon Health, Geelong, VIC 3220 Australia (
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Infection Control & Hospital Epidemiology
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  • EISSN: 1559-6834
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