Skip to main content
×
Home
    • Aa
    • Aa

Control of Influenza in the Long-Term–Care Facility: A Review of Established Approaches and Newer Options

  • Nancy H. Arden (a1)
Abstract
Abstract

Influenza infections pose a serious threat to residents of nursing homes and other long-term–care facilities. Annual vaccination of residents and staff with the currently licensed inactivated influenza vaccine continues to be the mainstay of prevention. Live attenuated influenza vaccine, which is expected to be licensed in the United States in the near future, may offer added protection for elderly persons when administered in conjunction with inactivated vaccine. Antiviral agents also can be useful as an adjunct to vaccination, especially for control of institutional outbreaks. Two new antiviral agents that appear to be less toxic than amantadine and rimantadine have recently been approved.

Copyright
Corresponding author
9253 Brookwater Cr, College Station, TX 77845
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. L Simonsen , MJ Clarke , GD Williamson , DF Stroup , NH Arden , LB Schonberger . The impact of influenza on mortality: introducing a severity index. Am J Public Health 1997;87:19441950.

2. TC Eickhoff , IL Sherman , RE Serfling . Observations on excess mortality associated with epidemic influenza. JAMA 1961;176:776782.

4. RA Goodman , WA Orenstein , TF Munro , SC Smith , RK Sikes . Impact of influenza A in a nursing home. JAMA 1982;247:14511453.

5. DM Morens , VM Rash . Lessons from a nursing home outbreak of influenza A. Infect Control Hosp Epidemiol 1995;16:275280.

6. WN Hall , RA Goodman , GR Noble , AP Kendal , RS Steece . An outbreak of influenza B in an elderly population. J Infect Dis 1981;144:297302.

8. RB Couch , JA Kasel , Immunity to influenza in man. Annu Rev Microbiol 1983;37:529549.

9. DC Powers . Effect of age on serum immunoglobulin G subclass antibody responses to inactivated influenza virus vaccine. J Med Virol 1994;43:5761.

10. PA Patriarca , JA Weber , RA Parker , WN Hall , AP Kendal , DJ Bregman , et al. Efficacy of influenza vaccine in nursing homes: reduction in illness and complications during an influenza A (H3N2) epidemic. JAMA 1985;253:11361139.

13. PA Gross , AW Hermogenes , HS Sacks , J Lau , RA Levandowski . The efficacy of influenza vaccine in elderly persons: a meta-analysis and review of the literature. Ann Intern Med 1995;123:518527.

14. KL Nichol , KL Margolis , J Wouremna , T von Sternberg . Effectiveness of influenza vaccine in elderly. Gerontology 1996:42:274279.

15. FB Coles , GJ Balzano , DL Morse , An outbreak of influenza A (H3N2) in a well immunized nursing home population. J Am Geriatr Soc 1992;40:589592.

16. RW Christie , LL Marquis . Immunization roulette: influenza occurrence in five nursing homes. Am J Infect Control 1985;13:174177.

18. NH Arden , AS Monto , SE Ohmit . Vaccine use and risk of institutional outbreaks in a sample of nursing homes during a type A (H3N2) influenza epidemic. Am J Public Health 1995;85:399401.

19. AP Kendal , PA Patriarca , NH Arden . Policies and outcomes for control of influenza among the elderly in the USA. Vaccine 1985;3 (suppl) :274276.

21. J Potter , DJ Statt , MA Roberts , AG Elder , B O'Donnell , PV Knight , et al. Influenza vaccination of health care workers in long-term-care hospitals reduces the mortality of elderly patients. J Infect Dis 1997;175:16.

23. FL Ruben , F Johnston , EJ Streift . Influenza in a partially immunized aged population: effectiveness of killed Hong Kong vaccine against infection with the England strain. JAMA 1974;230:863866.

25. NH Arden , PA Patriarca MW Harmon , JK Lui , F Brandon , AP Kendal . Safety and immunogenirity of a 45-μg supplemental dose of inactivated influenza B vaccine in the elderly. J Infect Dis 1986;153:805806.

26. NL Peters , G Meiklejohn , DW Jahnigen . Antibody response of an elderly population to a supplemental dose of influenza B vaccine. J Am Geriatr Soc 1988;36:593599.

27. PA Gross , GV Quinnan , ME Weksler , PF Gaerlan , CR. Denning Immunization of elderly people with high doses of influenza vaccine. J Am Geriatr Soc 1988;36:209212.

30. WE Beyer , AM Palache , M Baljet , N Masurel . Antibody induction by influenza vaccines in the elderly: a review of the literature. Vaccine 1989;7:385394.

31. M Levine , BL Beattie , DM McLean , D Corman . Characterization of the immune response to trivalent influenza vaccine in elderly men. J Am Geriatr Soc 1987;35:609615.

32. PA Gross , GV Quinnan Jr, ME Weksler , U Setia , RG Douglas Jr. Relation of chronic disease and immune response to influenza vaccine in the elderly. Vaccine 1989;7:303308.

34. RB Belshe , PM Mendelman , J Treanor , J King , WC Gruber , R Piedra . et al. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenza-virus vaccine in children. N Engl JMed 1998;338:14051412.

36. GJ Gorse , MJ Campbell , EE Otto , DC Powers , GW Chambers , FK Newman , Increased anti-influenza A virus cytotoxic T cell activity following vaccination of the chronically ill elderly with live attenuated or inactivated influenza virus vaccine. J Infect Dis 1995;172:110.

39. JJ Treanor , HR Mattison , G Dumyati , A Yinnon , S Erb , D O'Brien , et al. Protective effect of combined live intranasal and inactivated influenza A vaccines in the elderly. Ann Intern Med 1992;117:625633.

41. DP Calfee , FG Hayden . New approaches to influenza chemotherapy: neuraminidase inhibitors. Drugs 1998;56:537553.

42. FG Hayden , AD Osterhaus , JJ Treanor , DM Fleming , FY Aoki , KG Nicholson , et al. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. GG167 Influenza Study Group. N Engl J Med 1997;337:874880.

44.The Mist Study Group. Randomized trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections. Lancet 1998;352:18771881.

45. AS Monto , DP Robinson , ML Herlocher , JM Hinson , MJ Elliott , A Crisp . Zanamivir in the prevention of influenza among healthy adults: a randomized controlled trial. JAMA 1999;282:3135.

48. MJ Daniel , JM Barnett , BA Pearson . The low potential for drug interactions with zanamivir. Clin Pharmacokinet 1999;36(suppl 1):4150.

50. JM Colacino , WG Laver , GM Air . Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture. J Infect Dis 1997;176(suppl 1):S66S68.

52. TJ Blick , T Tiong , A Sahasrabudhe , JN Varghese , PM Colman , GJ Hart , et al. Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-spe-cific inhibitor 4-guanidino-Neu5Ac2en. Virology 1995;214:475484.

54. AS Monto , NH Arden . Implications of viral resistance to amantadine in control of influenza A. Clin Infect Dis 1992;15 (suppl l):362367.

56. FG Hayden , RB Belshe , RD Clover , AJ Hay , MG Oakes , W Soo . Emergence and apparent transmission of rimantadine-resistant influenza A virus in families. N Engl J Med 1989;321:16961702.

58. HG Gomolin , HB Leib , NH Arden , FT Sherman . Control of influenza outbreaks in the nursing home: guidelines for diagnosis and management. JAm Geriatr Soc 1995;43:7174.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 1 *
Loading metrics...

Abstract views

Total abstract views: 76 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st August 2017. This data will be updated every 24 hours.