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Current Definitions of Central Line–Associated Bloodstream Infection Is the Emperor Wearing Clothes?

  • Daniel J. Sexton (a1), Luke F. Chen (a1) and Deverick J. Anderson (a1)


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Box 102359, Duke University Medical Center, Durham, North Carolina, 27710, (


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1.Pronovost, P, Needham, D, Berenholtz, S, et al.An intervention to decrease catheter-related BSIs in the ICU. N Engl J Med 2006;355(26):27252732.
2.Cooper, LM, Oden, MA, Elliott, BK, Harger, IA, Anderson, DJ. Increased hand hygiene observations add validity to infection control data—but how to achieve in a busy hospital world? In: Program and abstracts of the Fifth Decennial International Conference on Healthcare-Associated Infections; Atlanta, GA; 2010.
3.Shuman, EK, Washer, LL, Arndt, JL, et al.Analysis of central line-associated BSIs in the intensive care unit after implementation of central line bundles. Infect Control Hosp Epidemiol 2010;31(5):551553.
4.National Healthcare Safety Network (NHSN). Central line-associated BSI (CLABSI) event. Updated June 2010. Accessed October 13, 2010.
5.O'Boyle, CJ, MacFie, J, Mitchell, CJ, Johnstone, D, Sagar, PM, Sedman, PC. Microbiology of bacterial translocation in humans. Gut 1998;42(1):2935.
6.MacFie, J, O'Boyle, C, Mitchell, CJ, Buckley, PM, Johnstone, D, Sudworth, P. Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity. Gut 1999;45(2):223228.
7.Reddy, BS, MacFie, J, Gatt, M, Macfarlane-Smith, L, Bitzopoulou, K, Snell-ing, AM. Commensal bacteria do translocate across the intestinal barrier in surgical patients. Clin Nutr 2007;26(2):208215.
8.Reddy, BS, Gatt, M, Sowdi, R, MacFie, J. Surgical manipulation of the large intestine increases bacterial translocation in patients undergoing elective colorectal surgery. Colorectal Dis 2006;8(7):596600.
9.Woodcock, NP, Sudheer, V, El-Barghouti, N, Perry, EP, MacFie, J. Bacterial translocation in patients undergoing abdominal aortic aneurysm repair. Br I Surg 2000;87(4):439442.
10.Turner, JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009;9(11):799809.
11.Stechmiller, JK, Treloar, D, Allen, N. Gut dysfunction in critically ill patients: a review of the literature. Am J Crit Care 1997;6(3):204209.
12.Van Leeuwen, PA, Boermeester, MA, Houdijk, AP, et al.Clinical significance of translocation. Gut 1994;35(1 Suppl):S28S34.
13.Weinstein, MP, Towns, ML, Quartey, SM, et al.The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 1997;24(4):584602.
14.Weinstein, MP, Relier, LB, Murphy, IR, Lichtenstein, KA. The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. Rev Infect Dis 1983;5(1):3553.
15.Beezhold, DW, Slaughter, S, Hayden, MK, et al.Skin colonization with vancomycin-resistant enterococci among hospitalized patients with bacteremia. Clin Infect Dis 1997;24(4):704706.
16.Hall, KK, Lyman, JA. Updated review of blood culture contamination. Clin Microbiol Rev 2006;19(4):788802.
17.Weinstein, MP. Blood culture contamination: persisting problems and partial progress. J Clin Microbiol 2003;41(6):22752278.
18.Chen, LF, Freeman, JT, Sexton, DJ, Choi, YI, Anderson, DJ. NHSN definition of laboratory-detected BSI is overly sensitive for Enterococcus. In: Program and abstracts of the 19th Annual Scientific Meeting of the Society for Healthcare Epidemiology of America (SHEA); San Diego, CA; 2009.
19.Friedman, ND, Kaye, KS, Stout, IE, et al.Health care-associated BSIs in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002;137(10):791797.
20.McDonald, LC, Coignard, B, Dubberke, E, Song, X, Horan, T, Kutty, PK. Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 2007;28(2):140145.
21.Sassetti, CM, Rubin, EJ. The open book of infectious diseases. Nat Med 2007;13(3):279280.


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