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Does Nasal Colonization or Mupirocin Treatment Affect Recurrence of Methicillin-Resistant Staphylococcus aureus Skin and Skin Structure Infections?

  • Joseph Rahimian (a1), Raymond Khan (a2) and Keith A. LaScalea (a3)
Abstract

Some patients with community-associated methicillin-resistant Staphylococcus aureus skin and skin structure infections have experienced frequent recurrences. We performed a retrospective study and determined that the presence of nasal colonization did not affect recurrence and nasal mupirocin treatment marginally decreased recurrence

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Corresponding author
Weill Cornell Medical College, 201 East 80th Street, New York, NY 10075 (kal9006@med.cornell.edu)
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1. EA Eady , JH Cove . Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus—an emerging problem for the management of skin and soft tissue infections. Curr Opin Infect Dis 2003;16:103124.

2. BW Frazee , J Lynn , ED Charlesbois , L Labert , D Lowery , F Perdreau-Remington . High Prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections. Ann Emerg Med 2005;45:311320.

3. SK Fridkin , JC Hageman , M Morrison , et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med 2005;352 14361444

5. U Rohr , C Mueller , M Wilhelm , G Muhr , S Gatermann . Methicillin-resistant Staphylococcus aureus whole body decolonization among hospitalized patients with variable site colonization by using mupirocin in combination with octenidine dihydrochloride. J Hosp Infect 2003;54 305309.

6. K Laupland , J Conly . Treatment of Staphylococcus aureus colonization and prophylaxis for infection with topical intranasal Mupirocin: an evidence-based review. Clin Infect Dis 2003;37:933938.

7. L Mody , C Kauffman , S McNeil , A Galecki , S Bradley . Mupirocin-based decolonization of Staphylococcus aureus carriers in residents of 2 long-term care facilities: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2003;37:14671474.

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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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