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Does Nasal Colonization or Mupirocin Treatment Affect Recurrence of Methicillin-Resistant Staphylococcus aureus Skin and Skin Structure Infections?

  • Joseph Rahimian (a1), Raymond Khan (a2) and Keith A. LaScalea (a3)

Some patients with community-associated methicillin-resistant Staphylococcus aureus skin and skin structure infections have experienced frequent recurrences. We performed a retrospective study and determined that the presence of nasal colonization did not affect recurrence and nasal mupirocin treatment marginally decreased recurrence

Corresponding author
Weill Cornell Medical College, 201 East 80th Street, New York, NY 10075 (
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1. EA Eady , JH Cove . Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus—an emerging problem for the management of skin and soft tissue infections. Curr Opin Infect Dis 2003;16:103124.

2. BW Frazee , J Lynn , ED Charlesbois , L Labert , D Lowery , F Perdreau-Remington . High Prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections. Ann Emerg Med 2005;45:311320.

3. SK Fridkin , JC Hageman , M Morrison , et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med 2005;352 14361444

5. U Rohr , C Mueller , M Wilhelm , G Muhr , S Gatermann . Methicillin-resistant Staphylococcus aureus whole body decolonization among hospitalized patients with variable site colonization by using mupirocin in combination with octenidine dihydrochloride. J Hosp Infect 2003;54 305309.

6. K Laupland , J Conly . Treatment of Staphylococcus aureus colonization and prophylaxis for infection with topical intranasal Mupirocin: an evidence-based review. Clin Infect Dis 2003;37:933938.

7. L Mody , C Kauffman , S McNeil , A Galecki , S Bradley . Mupirocin-based decolonization of Staphylococcus aureus carriers in residents of 2 long-term care facilities: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2003;37:14671474.

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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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