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Effective Antibiotic Conservation by Emergency Antimicrobial Stewardship During a Drug Shortage

  • Kevin Hsueh (a1), Maria Reyes (a1), Tamara Krekel (a2), Ed Casabar (a2), David J. Ritchie (a2) (a3), S. Reza Jafarzadeh (a1), Amanda J. Hays (a4), Michael A. Lane (a1) (a4) and Michael J. Durkin (a1) (a5)...


We present the first description of an antimicrobial stewardship program (ASP) used to successfully manage a multi-antimicrobial drug shortage. Without resorting to formulary restriction, meropenem utilization decreased by 69% and piperacillin-tazobactam by 73%. During the shortage period, hospital mortality decreased (P=.03), while hospital length of stay remained unchanged.

Infect Control Hosp Epidemiol 2017;38:356–359


Corresponding author

Address correspondence to Kevin Hsueh, MD, Division of Infectious Diseases, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8051, St. Louis, MO, 63110 (


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Supplementary materials

Hsueh supplementary material
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