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The epidemiological impact and significance of carbapenem resistance in Pseudomonas aeruginosa bloodstream infections: a matched case–case-control analysis

Published online by Cambridge University Press:  14 August 2018

Tzach Aviv ,
Tsillia Lazarovitch ,
David Katz ,
Ronit Zaidenstein ,
Mor Dadon ,
Chen Daniel ,
Ruthy Tal-Jasper ,
Keith S. Kaye  and
Dror Marchaim
Tzach Aviv
Affiliation:
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Tsillia Lazarovitch
Affiliation:
Clinical Microbiology Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel
David Katz
Affiliation:
Department of Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
Ronit Zaidenstein
Affiliation:
Unit of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, Israel,
Mor Dadon
Affiliation:
Unit of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, Israel,
Chen Daniel
Affiliation:
Unit of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, Israel,
Ruthy Tal-Jasper
Affiliation:
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Keith S. Kaye
Affiliation:
Department of Medicine, University of Michigan, Ann Arbor, Michigan, United States
Dror Marchaim*
Affiliation:
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel Unit of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, Israel,
*
Author for correspondence: Dror Marchaim, MD, Unit of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, 70300, Israel. E-mail: drormarchaim@gmail.com
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Abstract

A case–case-control investigation (N = 255 patients) explored the epidemiology of carbapenem-resistant Pseudomonas aeruginosa (CRPA). Recent exposure to carbapenems and a rapidly fatal condition should prompt practitioners to shorten delays in initiating appropriate therapy, which can adversely impact CRPA outcomes, as opposed to the isolated impact of the carbapenem resistance determinant.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 39 , Issue 10 , October 2018 , pp. 1262 - 1265
Copyright
© 2018 by The Society for Healthcare Epidemiology of America. All rights reserved 

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