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Failure of Risk-Adjustment by Test Method for C. difficile Laboratory-Identified Event Reporting

  • Alexandre R. Marra (a1) (a2), Michael B. Edmond (a1) (a3), Bradley A. Ford (a4), Loreen A. Herwaldt (a3), Abdullah R. Algwizani (a1) and Daniel J. Diekema (a1) (a3) (a4)...


Using an algorithm including both enzyme immunoassay (EIA) and nucleic acid amplification (NAAT) for Clostridium difficile infection (CDI) diagnosis, we found that the use of NAAT versus EIA almost doubled our hospital-onset CDI laboratory-identified (LabID) event standardized infection ratio (SIR). We recommend that the current risk adjustment approach be modified.

Infect Control Hosp Epidemiol 2016:1–3


Corresponding author

Address correspondence to Alexandre Rodrigues Marra, MD, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 (


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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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