To the Editor—Infection prevention programs have been consumed by coronavirus disease 2019 (COVID-19) pandemic response efforts. There is concern that preoccupation with COVID-19 mitigation efforts might affect traditional healthcare-associated infection (HAI) surveillance and prevention operations. ^{Reference Stevens, Doll, Pryor, Godbout, Cooper and Bearman1} Evidence surrounding the impact of COVID-19 on traditional infection prevention efforts has been limited to anecdotal data and retrospective studies of highly variable quality.

We conducted 4 PubMed searches on February 4, 2021, utilizing the following search terms: “COVID-19 and healthcare associated infections,” “COVID-19 and central line associated bloodstream infections,” “COVID-19 and Clostridioides difficile infections” and “COVID-19 and catheter associated urinary tract infections.” In total, 43 relevant articles were retrieved; of these, only 10 reported on our outcomes of interest. The reported data were limited to retrospective cohort studies of variable quality. Key representative studies are included in Table 1.2–6 Within these limitations, these data show an increase in bloodstream infections (BSIs) in hospitals that experienced a breakdown in infection prevention best practices during COVID-19 surges while also demonstrating a decrease in Clostridioides difficile infection (CDI) rates.

A health system in Singapore reported a significant reduction in central-line–associated bloodstream infection (CLABSI) rates during the pandemic compared with prepandemic rates. ^{Reference Wee, Conceicao and Tan2} The authors note that prior experience with severe acute respiratory syndrome (SARS) in 2003 led to the early adoption of enhanced infection prevention strategies. In contrast, other hospitals reported that COVID-19 negatively impacted infection prevention practices and observed increased BSI rates. ^{Reference LeRose, Sandhu and Polistico3,Reference Buetti, Ruckly and Montmollin4,Reference Sturdy, Basarab and Cotter7} Suboptimal nurse-to-patient ratios, barriers to accessing personal protective equipment, and barriers to performing hand hygiene were reported, as well as increased blood culture contamination rates. ^{Reference LeRose, Sandhu and Polistico3,Reference Buetti, Ruckly and Montmollin4,Reference Sturdy, Basarab and Cotter7} Data related to catheter-associated urinary tract infections (CAUTIs) are more limited. A single study from Singapore reported no change in CAUTI rates. ^{Reference Wee, Conceicao and Tan2} Although not peer reviewed, the Association of Professionals in Infection Control and Epidemiology conducted a survey in which 21.4% of respondents noted an increase in CAUTIs during the pandemic and another 27.8% noted an increase in CLABSIs. ⁸ Among the 3 studies included in Table 1 reporting comparative data on CDI rates, either a reduction in CDI rate or no change in CDI rate was observed. ^{Reference Wee, Conceicao and Tan2,Reference Bentivegna, Alessio and Spuntarelli5,Reference Ponce-Alonso, Fuente and Rincón-Carlavilla6}

Table 1. Key Articles on COVID-19 and Healthcare-Associated Infections

Note. CLABSI, central-line–associated bloodstream infection; CAUTI, catheter-associated urinary tract infection; CDI, Clostridiodes difficile infection; BSI, bloodstream infection; IRR, incidence-rate-ratio; PPE, personal protective equipment; HR, hazard ratio.

Although the data are limited, at least 1 health system with robust outbreak preparedness was able to mitigate the impact of the COVID-19 pandemic and actually reported a significant reduction in CLABSIs. Conversely, multiple other health systems that reported a breakdown in infection prevention best practices reported increases in BSIs. Ultimately, our understanding of the impact of the COVID-19 pandemic on HAIs will be limited, due in part to the relaxation of mandatory reporting requirements during the pandemic. ^{Reference Stevens, Doll, Pryor, Godbout, Cooper and Bearman1} Data on healthcare-associated non–central-catheter–associated BSI rates will be particularly limited because reporting in the United States is not mandated.

Currently, the full scope of the impact of COVID-19 on HAIs is unclear. However, important opportunities exist for health systems (both on the local level and nationally) to utilize their experiences during the current pandemic to bolster infrastructure and to robustly prepare for and quickly respond to future pandemic threats.