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Institution-wide and Within-Patient Evolution of Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium Bloodstream Infections

Published online by Cambridge University Press:  14 January 2018

Robert J. Woods ,
Twisha S. Patel ,
Jerod L. Nagel ,
Duane W. Newton  and
Andrew F. Read
Robert J. Woods*
Affiliation:
Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan
Twisha S. Patel
Affiliation:
Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan
Jerod L. Nagel
Affiliation:
Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan
Duane W. Newton
Affiliation:
Department of Pathology, Michigan Medicine, Ann Arbor, Michigan
Andrew F. Read
Affiliation:
Department of Biology, The Pennsylvania State University, University Park, Pennsylvania
*
Address correspondence to Robert J. Woods, MD, PhD, 5510C MSRB I, SPC 5680; 1150 W. Medical Center Dr, Ann Arbor, MI 48109-5680 (robertwo@med.umich.edu).
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Abstract

We report daptomycin minimum inhibitory concentrations (MICs) for vancomycin-resistant Enterococcus faecium isolated from bloodstream infections over a 4-year period. The daptomycin MIC increased over time hospital-wide for initial isolates and increased over time within patients, culminating in 40% of patients having daptomycin-nonsusceptible isolates in the final year of the study.

Infect Control Hosp Epidemiol 2018;39:226–228

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 39 , Issue 2 , February 2018 , pp. 226 - 228
Copyright
© 2018 by The Society for Healthcare Epidemiology of America. All rights reserved 

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Footnotes

PREVIOUS PRESENTATION: These results were previously presented as poster number D-1176 at the 55th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 17, 2015, in San Diego, California.

References

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