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Molecular Characterization of Methicillin-Resistant Staphylococcus aureus Spread by Neonates Transferred From Primary Obstetrics Clinics to a Tertiary Care Hospital in Korea

Published online by Cambridge University Press:  21 June 2016

Kwan Soo Ko ,
Sulhee Park ,
Kyong Ran Peck ,
Eun Jung Shin ,
Won Sup Oh ,
Nam Yong Lee  and
Jae-Hoon Song
Kwan Soo Ko
Affiliation:
Asian-Pacific Research Foundation for Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Sulhee Park
Affiliation:
Asian-Pacific Research Foundation for Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Kyong Ran Peck*
Affiliation:
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Eun Jung Shin
Affiliation:
Infection Control Office, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Won Sup Oh
Affiliation:
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Nam Yong Lee
Affiliation:
Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Jae-Hoon Song
Affiliation:
Asian-Pacific Research Foundation for Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
*
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Il-won dong, Kangnam-ku, Seoul 135-710, Korea (krpeck@smc.samsung.co.kr)
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Abstract

Objective.

To investigate the characteristics and origins of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from neonatal patients admitted to a tertiary care hospital from local and primary care obstetrics clinics.

Design.

Molecular typing study.

Setting.

A 1,278-bed tertiary care hospital (Samsung Medical Center) and 2 primary obstetrics clinics in Seoul, Korea.

Patients.

The genotypic characteristics of 12 MRSA samples isolated from 11 neonatal patients transferred from 2 primary care obstetrics clinics to a tertiary care hospital were investigated by means of multilocus sequence typing, spa (staphylococcal protein A) typing, and SCCmec typing. Ten MRSA strains isolated from workers and environments in the associated obstetrics clinics were also investigated.

Results.

Although the antibiograms of isolates from 2 obstetrics clinics differed, no strain showed multidrug resistance to antimicrobials. Multilocus sequence typing analysis showed that all 22 MRSA isolates analyzed in this study had sequence type 1 (with the allelic profile 1-1-1-1-1-1-1), sequence type 493 (62-1-1-1-1-1-1), or a novel sequence type (25-1-1-1-1-1-1) and that all belonged to a single clonal complex (clonal complex 1). Moreover, they all contained SCCmec type IVA and the identical spa type (UJEBKBP). These genotypic characteristics are similar to those of typical community-associated MRSA strains rather than the hospital-acquired MRSA strains common in Korea.

Conclusion.

The findings of this study suggest that community-acquired MRSA strains can spread in primary care clinics and be imported into tertiary care settings.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 6 , June 2006 , pp. 593 - 597
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

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