Skip to main content Accessibility help
×
×
Home

A Multicenter Study on Optimizing Piperacillin-Tazobactam Use: Lessons on Why Interventions Fail

  • Robert P. Gaynes (a1) (a2) (a3), Carolyn V. Gould (a1) (a2), Jonathan Edwards (a1), Theresa L. Antoine (a1), Henry M. Blumberg (a2) (a4), Kathryn DeSilva (a3), Mark King (a2) (a4), Alice Kraman (a5), Jan Pack (a6), Bruce Ribner (a2) (a6), Ulrich Seybold (a7), James Steinberg (a2) (a5) and John A. Jernigan (a1) (a2)...

Abstract

We examined interventions to optimize piperacillin-tazobactam use at 4 hospitals. Interventions for rotating house staff did not affect use. We could target empiric therapy in only 35% of cases. Because prescribing practices seemed to be institution specific, interventions should address attitudes of local prescribers. Interventions should target empiric therapy and ordering of appropriate cultures.

Copyright

Corresponding author

Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop A-24, Atlanta, GA 30333 (rgaynes@cdc.gov)

References

Hide All
1.Centers for Disease Control and Prevention NNIS System. National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992 through June 2003, issued August 2003. Am J Infect Control 2003;31:481498.
2.Antoine, TL, Curtis, AB, Blumberg, HM, et al.Knowledge, attitudes, and behaviors regarding piperacillin-tazobactam prescribing practices: results from a multicenter study. Infect Control Hosp Epidemiol 2006;27:12741277.
3.Evans, RRS, Classen, DC, Pestotnik, SL, Lundsgaarde, HP, Burke, JP. Improving empiric antibiotic selection using computer decision support. Arch Intern Med 1994;154:878884.
4.Pestotnik, SL, Classen, DC, Evans, RS, Burke, JP. Implementing antibiotic practice guidelines through computer-assisted decision support: clinical and financial outcomes. Ann Intern Med 1996;124:884890.
5.Sellors, J, Kaczorowski, J, Sellors, C, et al.A randomized controlled trial of a pharmacist consultation program for family physicians and their elderly patients. CMAJ 2003;169:1722.
6.Arnold, FW, McDonald, LC, Newman, D, Smith, RS, Ramirez, JA. Improving antimicrobial use: longitudinal assessment of an antimicrobial team including a clinical pharmacist. J Manag Care Pharm 2004;10:152158.
7.Paskovaty, A, Pflomm, JM, Myke, N, Seo, SK. A multidisciplinary approach to antimicrobial stewardship: evolution into the 21st century. Int J Antimicrob Agents 2005;25:110.
8.Eccles, M, Grimshaw, J, Steen, N, et al.The design and analysis of a randomised controlled trial to evaluate computerised decision support in primary care: the COGENT Study. Fam Pract 2000;17:180186.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed