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Nosocomial Methicillin-Resistant and Methicillin-Susceptible Staphylococcus Aureus Primary Bacteremia: At What Costs?

  • Murray A. Abramson (a1) and Daniel J. Sexton (a1)
Abstract
Objective:

To determine the attributable hospital stay and costs for nosocomial methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S aureus (MRSA) primary bloodstream infections (BSIs).

Design:

Pairwise-matched (1:1) nested case-control study.

Setting:

University-based tertiary-care medical center.

Patients:

Patients admitted between December 1993 and March 1995 were eligible. Cases were defined as patients with a primary nosocomial S aureus BSI; controls were selected according to a priori matching criteria.

Measurements:

Length of hospital stay and total and variable direct costs of hospitalization.

Results:

The median hospital stay attributable to primary nosocomial MSSA BSI was 4 days, compared with 12 days for MRSA (P=.023). Attributable median total cost for MSSA primary nosocomial BSIs was $9,661 versus $27,083 for MRSA nosocomial infections (P=.043).

Conclusion:

Nosocomial primary BSI due to S aureus significantly prolongs the hospital stay. Primary nosocomial BSIs due to MRSA result in an approximate threefold increase in direct cost, compared with those due to MSSA.

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Corresponding author
PO Box 17969, Durham, NC 27715
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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