Hostname: page-component-76fb5796d-vfjqv Total loading time: 0 Render date: 2024-04-26T06:42:41.030Z Has data issue: false hasContentIssue false
  • English
  • Français

Nosocomial Spread of Clostridium Difficile

Published online by Cambridge University Press:  02 January 2015

Alice M. Savage  and
Robert H. Alford
Alice M. Savage*
Affiliation:
Division of Infectious Diseases, Veterans Administration Medical Center, and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
Robert H. Alford
Affiliation:
Division of Infectious Diseases, Veterans Administration Medical Center, and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
*
VA Medical Center, 1310 24th Avenue, South, Nashville, TN 37203
Get access Rights & Permissions [Opens in a new window]

Abstract

Environmental transmission of Clostridium difficile, the causative agent of antibiotic-associated pseudomembranous colitis (PMC), has been supported by animal studies and implicated in spread of C. difficile among leukemic children receiving non-absorbable antibiotics. We report antibiotic-associated C. difficile-related colitis in two adults who shared a commode chair during hospitalization.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 4 , Issue 1 , February 1983 , pp. 31 - 33
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.George, WL, Sutter, VL, Finegold, SM, Antimicrobial agent-induced diarrhea — A bacterial disease. J Infect Dis 1977;136:822–828.CrossRefGoogle ScholarPubMed
2.Bartlett, JG, Antimicrobial agents implicated in Clostridium difficile toxin-associated diarrhea or colitis. Johns Hopkins Med J 1981;149:6–9.Google ScholarPubMed
3.Larson, HE, Price, AB, Borriello, SP, Epidemiology of experimental enterocecitis due to Clostridium difficile. J Infect Dis 1980;142:408–413.CrossRefGoogle ScholarPubMed
4.Fekety, R, Kim, K-H, Batts, DH, et al: Studies on the epidemiology of antibiotic-associated Clostridium difficile colitis. Am J Clin Nutr 1980;33:2527–2532.CrossRefGoogle ScholarPubMed
5.Rodgers, TR, Petrou, M, Lucas, C, et al: Spread of Clostridium difficile among patients receiving non-absorbable antibiotics for gut decontamination. Br Med J 1981;283:408–409.CrossRefGoogle Scholar
6.Tedesco, FJ, Antibiotic associated pseudomembranous colitis with negative proctosigmoidoscopy examination. Gastroenterology 1979;77:295–297.CrossRefGoogle ScholarPubMed
7.Keighley, MRB, Burdon, DW, Arabi, Y, et al: Randomized controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhea. Br Med J 1978;2:1667–1669.CrossRefGoogle Scholar
8.Silva, J Jr, Batts, DH, Fekety, R, et al: Treatment of Clostridium difficile colitis and diarrhea with vancomycin. Am J Med 1981;71:815–822.CrossRefGoogle ScholarPubMed
9.Tedesco, FJ, Antibiotic-associated colitis — An abating enigma. J Clin Gastroenterol 1981;3:221–224.CrossRefGoogle ScholarPubMed
10.George, WL, Volpicelli, NA, Stiner, DB, et al: Relapse of pseudomembranous colitis after vancomycin therapy. N Engl J Med 1979;301:414–415.CrossRefGoogle ScholarPubMed
11.Bartlett, JG, Tedesco, FJ, Shull, S, et al: Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis. Gastroenterology 1980;78:431–434.CrossRefGoogle ScholarPubMed
12.Mulligan, ME, George, WL, Rolfe, RD, et al: Epidemiological aspects of Clostridium difficile-induced diarrhea and colitis. Am J Clin Nutr 1980;33:2533–2538.CrossRefGoogle ScholarPubMed
13.Fekety, R, Kim, K-H, Brown, D, et al: Epidemiology of antibiotic-associated colitis isolation of Clostridium difficile from the hospital environment. Am J Med 1981;70:906–908.CrossRefGoogle ScholarPubMed
14.Brettle, RP, Poxton, IR, Murdoch, J, et al: Clostridium difficile in association with sporadic diarrhea. Br Med J 1982;284:230–233.CrossRefGoogle Scholar
15.Bartlett, JG, Antibiotic-associated pseudomembranous colitis. Rev Infect Dis 1979;1:530–539.CrossRefGoogle ScholarPubMed
16.Lishman, AH, Al-Jumaili, IJ, Record, CO, Spectrum of antibiotic-associated diarrhea. Gut 1981;22:34–37.CrossRefGoogle Scholar
17.Viscidi, R, Willey, S, Bartlett, JG, Isolation rates and toxigenic potential of Clostridium difficile isolates from various patient populations. Gastroenterology 1981;81:5–9.CrossRefGoogle ScholarPubMed
18.Pierce, PF Jr, Wilson, R, Silva, J Jr, et al: Antibiotic-associated pseudomembranous colitis: An epidemiologic investigation of a cluster of cases. J Infect Dis 1982;145:269–274.CrossRefGoogle ScholarPubMed
19.Keighley, MRB, Burdon, DW, Alexander-Williams, J, et al: Diarrhea and pseudomembranous colitis after gastrointestinal operations — A prospective study. Lancet 1978;2:1165–1167.CrossRefGoogle ScholarPubMed
20.Fainstein, V, Bodey, GP, Fekety, R, Relapsing pseudomembranous colitis associated with cancer chemotherapy. J Infect Dis 1981;143:865.CrossRefGoogle ScholarPubMed
21.Trnka, YM, LaMont, JT, Association of Clostridium difficile toxin with symptomatic relapse of chronic inflammatory bowel disease. Gastroenterology 1981;80:693–696.CrossRefGoogle ScholarPubMed
22.Wald, A, Mendelow, H, Bartlett, JG, Non-antibiotic-associated pseudomembranous colitis due to toxin-producing Clostridia. Ann Intern Med 1980;92:798–799.CrossRefGoogle ScholarPubMed
23.Alder, SP, Chandrika, T, Berman, WF, Clostridium difficile associated with pseudomembranous colitis occurrence in a 12-week-old infant without prior antibiotic therapy. Am J Dis Child 1981;135:820–822.Google Scholar
24.Hyams, JS, Berman, MM, Helgason, H, Non-antibiotic-associated enterocolitis caused by Clostridium difficile in an infant. J Pediatr 1981;99:750–752.CrossRefGoogle Scholar
25.Moskovitz, M, Bartlett, JG, Recurrent pseudomembranous colitis unassociated with prior antibiotic therapy. Arch Intern Med 1981;141:663–664.CrossRefGoogle ScholarPubMed
26.Greenfield, C, Burroughs, A, Szawathowski, M, et al: Is pseudomembranous colitis infectious? Lancet 1981;1:371–372.CrossRefGoogle ScholarPubMed
27.Mills, PR, Main, ANH, Gemmell, CG, et al: Pseudomembranous colitis as infectious disease. Lancet 1981;1:552.CrossRefGoogle ScholarPubMed