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Outbreak of Acinetobacter baumannii Bacteremia Related to Contaminated Morphine Used for Patient-Controlled Analgesia

  • Hsin-Chun Lee (a1) (a2), Nan-Yao Lee (a2) (a3), Chia-Ming Chang (a2) (a3), Cheng-Yang Chou (a4), Yi-Hui Wu, Li-Rong Wang (a2), Nai-Ying Ko (a5), Ching-Chuan Liu (a6) (a2) and Wen-Chien Ko (a1) (a2) (a3)...
Abstract

We investigated a cluster of postoperative febrile episodes and episodes of Acinetobacter baumannii bacteremia in obstetrics and gynecology wards after an electrical blackout and loss of the water supply. The use of patient-controlled analgesia was the only independent risk factor associated with postoperative fever, and A. baumannii isolates recovered from the blood of patients who had received patient-controlled analgesia were genetically related to an isolate recovered from the diluted morphine solution used for this procedure. After inappropriate preparation of the morphine solution was identified and stopped, the outbreak ended.

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Corresponding author
Department of Internal Medicine, National Cheng Kung University, No. 138, Sheng-Li Road, 70403, Tainan, Taiwan (winston@mail.ncku.edu.tw)
References
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1. Fournier, PE, Richet, H. The epidemiology and control of Acinetobacter baumannii in healthcare facilities. Clin Infect Dis 2006;42:692699.
2. Murray, PR, Baron, EJ, Pfaller, MA, et al. Manual of Clinical Microbiology. 7th ed. Washington, DC: ASM Press;1999.
3. National Committee for Clinical Laboratory Standards (NCCLS). Performance Standards for Antimicrobial Susceptibility Testing: 11th Informational Supplement. Villanova, PA: NCCLS;1999:M100-S11.
4. Tenover, FC, Arbeit, RD, Goering, RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.
5. Siegman-Igra, Y, Jacobi, E, Lang, R, Schwartz, D, Carmeli, Y. Unexpected hospital-acquired bacteraemia in patients at low risk of bloodstream infection: the role of a heparin drip. J Hosp Infect 2005;60:122128.
6. Grohskopf, LA, Roth, VR, Feikin, DR, et al. Serratia liquefaciens bloodstream infections from contamination of epoetin alfa at a hemodialysis center. N Engl J Med 2001;344:14911497.
7. Goetz, AM, Rihs, JD, Chow, JW, Singh, N, Müder, RR. An outbreak of infusion-related Klebsiella pneumoniae bacteremia in a liver transplantation unit. Clin Infect Dis 1995;21:15011503.
8. Ostrowsky, BE, Whitener, C, Bredenberg, HK, et al. Serratia marcescens bacteremia traced to an infused narcotic. N Engl J Med 2002;346:15291537.
9. Bennett, SN, McNeil, MM, Bland, LA, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995;333:147154.
10. Kastango, ES. Blueprint for implementing USP chapter 797 for compounding sterile preparations. Am J Health Syst Pharm 2005;62:12711288.
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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