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Outbreak of Carbapenem-Resistant Providencia stuartii in an Intensive Care Unit

  • Alexandre P. Zavascki (a1), Cecília G. Carvalhaes (a2), Geórgia L. da Silva (a3), Sílvia Pedroso Tavares Soares (a3), Luciana R. de Alcåntara (a3), Laura S. Elias (a3), Ana M. Sandri (a3) and Ana C. Gales (a2)...


Outbreaks by carbapenem-resistant Providencia stuartii (CRPS) are rarely described. Clinical characteristics of patients with CRPS in an intensive care unit and resistance mechanisms were investigated. Carbapenemase production and/or outer membrane alterations were not detected; only CTX-M-2 and AmpC hyperproduction were noted. The outbreak was ultimately controlled in a 3-month period.


Corresponding author

Alexandre P. Zavascki, MD, PhD, Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos Street, Porto Alegre 90.035-903, Brazil (


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1. Lee, HW, Kang, HY, Shin, KS, Kim, J. Multidrug-resistant Providencia isolates carrying blaPER-1, blaVIM-2, and armA. J Microbiol 2007;45:272274.
2. Miriagou, V, Tzouvelekis, LS, Flevari, K, Tsakiri, M, Douzinas, EE. Providencia stuartii with VIM-1 metallo-β-lactamase. J Anti-microb Chemother 2007;60:183184.
3. Shiroto, K, Ishii, Y, Kimura, S, et al. Metallo-β-lactamase IMP-1 in Providencia rettgeri from two different hospitals in Japan. J Med Microbiol 2005;54:10651070.
4. Horan, TC, Andrus, M, Dudeck, MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309332.
5. Clinical and Laboratory Standards Institute. 2009. Performance standards for antimicrobial susceptibility testing. CLSI document M100-S19. Clinical and Laboratory Standards Institute, Wayne, PA.
6. Thomson, KS. Extended-spectrum-β-lactamase, AmpC, and car-bapenemase issues. J Clin Microbiol 2010;48:10191025.
7. Tenover, FC, Arbeit, RD, Goering, RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.
8. Poirel, L, Naas, T, Guibert, M, EB, Chaibi, Labia, R, Nordmann, P. Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum β-lactamase encoded by an Escherichia coli integran gene. Antimicrob Agents Chemother 1999;43: 573581.
9. Picão, RC, Poirel, L, Gales, AC, Nordmann, P. Diversity of β-lactamases produced by ceftazidime-resistant Pseudomonas aeru ginosa causing bloodstream infections in Brazil. Antimicrob Agents Chemother 2009;53:39083913.
10. Pérez-Pérez, FJ, Hanson, ND. Detection of plasmid-mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 2002;40:21532162.
11. Hernandez-Allés, S, Albertí, S, Alvarez, D, et al. Porin expression in clinical isolates of Klebsiella pneumoniae . Microbiology 1999; 145:673679.
12. Tran, QT, Mahendran, KR, Hajjar, E, et al. Implication of porins in β-lactam resistance of Providencia stuartii . J Biol Chem 2010; 285:3227332281.


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