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Pentamidine: A Review

Published online by Cambridge University Press:  21 March 2023

Brian Wispelwey  and
Richard D. Pearson
Brian Wispelwey*
Affiliation:
Departments of Internal Medicine and Pathology, the Divisions of Infectious Diseases and Geographic Medicine, the University of Virginia, Charlottesville, Virginia
Richard D. Pearson
Affiliation:
Departments of Internal Medicine and Pathology, the Divisions of Infectious Diseases and Geographic Medicine, the University of Virginia, Charlottesville, Virginia
*
University of Virginia, Division of Infectious Diseases, Box 397, Charlottesville, VA 22908
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Extract

With the advent of the acquired immunodeficiency syndrome (AIDS), the therapeutic importance of pentamidine isethionate has increased greatly. This review summarizes the pharmacology, clinical experience in the treatment of Pneumocystis carinii pneumonia, and toxicity of pentamidine. Data are conflicting as to whether pentamidine is more or less effective than trimethoprim-sulfamethoxazole (TMP-SX) for the treatment of P carinii pneumonia in individuals with AIDS, but due to its toxicity and expense, it is considered as second-line therapy for P carinii pneumonia by many authorities. Hypoglycemia has been encountered in up to 27%, and nephrotoxicity in 25%, of treatment courses with pentamidine. In an attempt to circumvent the toxicities associated with parenteral administration, aerosolized delivery has been evaluated for both therapy and prevention of P carinii pneumonia. Aerosolized pentamidine, on the basis of early clinical results, convenience, and low toxicity, is being used extensively to prevent P carinii pneumonia in individuals at high risk. Relapses occur, however, and pneumothorax may be more common in those using this form of prophylaxis. Aerosolized pentamidine should not be used as sole therapy for acute P carinii pneumonia.

Type
Clinical Pharmacology of Antibiotics
Information
Infection Control & Hospital Epidemiology , Volume 12 , Issue 6 , June 1991 , pp. 375 - 382
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1991

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