Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 22
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Ashfaq, Adeel Zhu, Allen Iyengar, Amit Wu, Hoover Humphries, Romney McKinnell, James A. Shemin, Richard and Benharash, Peyman 2016. Impact of an Institutional Antimicrobial Stewardship Program on Bacteriology of Surgical Site Infections in Cardiac Surgery. Journal of Cardiac Surgery, Vol. 31, Issue. 6, p. 367.


    Różańska, Anna Wójkowska-Mach, Jadwiga Bulanda, Małgorzata and Heczko, Piotr B. 2016. Surgical patients’ safety in Polish hospital environment in the context of selected infection control practices. Journal of Patient Safety & Infection Control,


    Cowperthwaite, Liz and Holm, Rebecca L. 2015. Guideline Implementation: Preoperative Patient Skin Antisepsis. AORN Journal, Vol. 101, Issue. 1, p. 71.


    Dumville, Jo C McFarlane, Emma Edwards, Peggy Lipp, Allyson Holmes, Alexandra Liu, Zhenmi and Dumville, Jo C 2015. Cochrane Database of Systematic Reviews.


    Echols, Kathryn Graves, Michael LeBlanc, Keith G. Marzolf, Sean and Yount, Avis 2015. Role of Antiseptics in the Prevention of Surgical Site Infections. Dermatologic Surgery, Vol. 41, Issue. 6, p. 667.


    Hannan, Margaret M. O'Sullivan, Katie E. Higgins, Ann M. Murphy, Ann-Marie McCarthy, James Ryan, Edmund and Hurley, John P. 2015. The Combined Impact of Surgical Team Education and Chlorhexidine 2% Alcohol on the Reduction of Surgical Site Infection following Cardiac Surgery. Surgical Infections, Vol. 16, Issue. 6, p. 799.


    Kramer, Axel Bekeschus, Sander Matthes, Rutger Bender, Claudia Stope, Matthias B. Napp, Matthias Lademann, Olaf Lademann, Jürgen Weltmann, Klaus-Dieter and Schauer, Frieder 2015. Cold Physical Plasmas in the Field of Hygiene-Relevance, Significance, and Future Applications. Plasma Processes and Polymers, Vol. 12, Issue. 12, p. 1410.


    Leaper, David and Ousey, Karen 2015. Evidence update on prevention of surgical site infection. Current Opinion in Infectious Diseases, Vol. 28, Issue. 2, p. 158.


    Prasetyono, Theddeus O.H. and Saputra, Debby K.A. 2015. Do We Need to Apply Antiseptics? A Review of Antiseptics Use in Cleft Lip Repair Procedure to Prevent Surgical Site Infection. Journal of Craniofacial Surgery, Vol. 26, Issue. 5, p. e461.


    Sajja, Lokeswara Rao 2015. Strategies to reduce deep sternal wound infection after bilateral internal mammary artery grafting. International Journal of Surgery, Vol. 16, p. 171.


    Webster, Joan Osborne, Sonya and Webster, Joan 2015. Cochrane Database of Systematic Reviews.


    Bryce, E. Wong, T. Forrester, L. Masri, B. Jeske, D. Barr, K. Errico, S. and Roscoe, D. 2014. Nasal photodisinfection and chlorhexidine wipes decrease surgical site infections: a historical control study and propensity analysis. Journal of Hospital Infection, Vol. 88, Issue. 2, p. 89.


    Charehbili, Ayoub Swijnenburg, Rutger-Jan van de Velde, Cornelis van den Bremer, Jephta and van Gijn, Willem 2014. A Retrospective Analysis of Surgical Site Infections after Chlorhexidine–Alcohol versus Iodine–Alcohol for Pre-Operative Antisepsis. Surgical Infections, Vol. 15, Issue. 3, p. 310.


    Graf, Karolin and Vonberg, Ralf-Peter 2014. Microbiology for Surgical Infections.


    Spruce, Lisa 2014. Back to Basics: Preventing Surgical Site Infections. AORN Journal, Vol. 99, Issue. 5, p. 600.


    Anderson, Maureen E C Foster, Brittany A and Weese, J 2013. Observational study of patient and surgeon preoperative preparation in ten companion animal clinics in Ontario, Canada. BMC Veterinary Research, Vol. 9, Issue. 1, p. 194.


    Bonnevialle, N. Geiss, L. Cavalié, L. Ibnoulkhatib, A. Verdeil, X. and Bonnevialle, P. 2013. Skin preparation before hip replacement in emergency setting versus elective scheduled arthroplasty: Bacteriological comparative analysis. Orthopaedics & Traumatology: Surgery & Research, Vol. 99, Issue. 6, p. 659.


    Bonnevialle, N. Geiss, L. Cavalié, L. Ibnoulkhatib, A. Verdeil, X. and Bonnevialle, P. 2013. Préparation cutanée avant prothèse de hanche en urgence versus prothèse de hanche programmée : analyse bactériologique comparative. Revue de Chirurgie Orthopédique et Traumatologique, Vol. 99, Issue. 6, p. 550.


    Dumville, Jo C McFarlane, Emma Edwards, Peggy Lipp, Allyson Holmes, Alexandra and Dumville, Jo C 2013. Cochrane Database of Systematic Reviews.


    Ferry, T. Valour, F. Lustig, S. Laurent, F. Perrin, G. Chidiac, C. and Barrey, C. 2013. The challenge of infection prevention in spine surgery: an update. European Journal of Orthopaedic Surgery & Traumatology, Vol. 23, Issue. S1, p. 15.


    ×
  • Infection Control & Hospital Epidemiology, Volume 33, Issue 6
  • June 2012, pp. 608-617

Preoperative Skin Antiseptic Preparations for Preventing Surgical Site Infections: A Systematic Review

  • Chris Kamel (a1), Lynda McGahan (a1), Julie Polisena (a1), Monika Mierzwinski-Urban (a1) and John M. Embil (a2)
  • DOI: http://dx.doi.org/10.1086/665723
  • Published online: 02 January 2015
Abstract
Objective.

To evaluate the clinical effectiveness of preoperative skin antiseptic preparations and application techniques for the prevention of surgical site infections (SSIs).

Design.

Systematic review of the literature using Medline, EMBASE, and other databases, for the period January 2001 to June 2011.

Methods.

Comparative studies (including randomized and nonrandomized trials) of preoperative skin antisepsis preparations and application techniques were included. Two researchers reviewed each study and extracted data using standardized tables developed before the study. Studies were reviewed for their methodological quality and clinical findings.

Results.

Twenty studies (n = 9,520 patients) were included in the review. The results indicated that presurgical antiseptic showering is effective for reducing skin flora and may reduce SSI rates. Given the heterogeneity of the studies and the results, conclusions about which antiseptic is more effective at reducing SSIs cannot be drawn.

Conclusions.

The evidence suggests that preoperative antiseptic showers reduce bacterial colonization and may be effective at preventing SSIs. The antiseptic application method is inconsequential, and data are lacking to suggest which antiseptic solution is the most effective. Disinfectant products are often mixed with alcohol or water, which makes it difficult to form overall conclusions regarding an active ingredient. Large, well-conducted randomized controlled trials with consistent protocols comparing agents in the same bases are needed to provide unequivocal evidence on the effectiveness of one antiseptic preparation over another for the prevention of SSIs.

Copyright
Corresponding author
600-865 Carling Avenue, Ottawa, Ontario K1S 5S8, Canada (chrisk@cadth.ca)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

8.SH Downs , N Black . The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998;52(6):377384.

9.A Liberati , DG Altman , J Tetzlaff , et al.The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009;62(10):e1e34.

10.MG Zywiel , JA Daley , RE Delanois , Q Naziri , AJ Johnson , MA Mont . Advance pre-operative Chlorhexidine reduces the incidence of surgical site infections in knee arthroplasty. Int Orthop 2011; 35(7):10011007.

11.MR Murray , MD Saltzman , SM Gryzlo , MA Terry , CC Woodward , GW Nuber . Efficacy of preoperative home use of 2% Chlorhexidine gluconate cloth before shoulder surgery. J Shoulder Elbow Surg 2011;20(6):928933.

12.DF Veiga , CA Damasceno , FJ Veiga , et al.Influence of povidone-iodine preoperative showers on skin colonization in elective plastic surgery procedures. Plast Reconstr Surg 2008;121(1): 115118.

14.B Dizer , S Hatipoglu , N Kaymakcioglu , et al.The effect of nurse-performed preoperative skin preparation on postoperative surgical site infections in abdominal surgery. J Clin Nurs 2009; 18(23):33253332.

15.AJ Johnson , JA Daley , MG Zywiel , RE Delanois , MA Mont . Preoperative Chlorhexidine preparation and the incidence of surgical site infections after hip arthroplasty. J Arthroplasty 2010; 25(suppl 6):98102.

16.JS Magera , BA Inman , DS Elliott . Does preoperative topical antimicrobial scrub reduce positive surgical site culture rates in men undergoing artificial urinary sphincter placement? J Urol 2007;178(4 pt 1):13281332.

17.DE Meier , SK Nkor , D Aasa , DA OlaOlorun , JL Tarpley . Prospective randomized comparison of two preoperative skin preparation techniques in a developing world country. World J Surg 2001;25(4):441443.

18.AJ Kalantar-Hormozi , B Davami . No need for preoperative antiseptics in elective outpatient plastic surgical operations: a prospective study. Plast Reconstr Surg 2005;116(2):529531.

21.DF Veiga , CA Damasceno , J Veiga-Filho , et al.Povidone iodine versus Chlorhexidine in skin antisepsis before elective plastic surgery procedures: a randomized controlled trial. Plast Reconstr Surg 2008;122(5):170e171e.

22.RO Darouiche , MJ Wall Jr, KM Itani , et al.Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med 2010;362(1):1826.

23.CG Segal , JJ Anderson . Preoperative skin preparation of cardiac patients. AORN J 2002;76(5):821828.

24.I Levin , J Amer-Alshiek , A Avni , JB Lessing , A Satei , B Almog . Chlorhexidine and alcohol versus povidone-iodine for antisepsis in gynecological surgery. J Womens Health (Larchmt) 2011;20(3): 321324.

27.BT Bucher , RM Guth , AM Elward , et al.Risk factors and outcomes of surgical site infection in children. J Am Coll Surg 2011; 212(6):10331038.

28.C Jacobson , DR Osmon , A Hanssen , et al.Prevention of wound contamination using DuraPrep solution plus Ioban 2 drapes. Clin Orthop Relat Res 2005;439:3237.

31.J Jakobsson , A Perlkvist , C Wann-Hansson . Searching for evidence regarding using preoperative disinfection showers to prevent surgical site infections: a systematic review. Worldviews Evid Based Nurs 2011;8(3):143152.

33.A Noorani , N Rabey , SR Walsh , RJ Davies . Systematic review and meta-analysis of preoperative antisepsis with Chlorhexidine versus povidone-iodine in clean-contaminated surgery. Br J Surg 2010;97(11):16141620.

35.RV Ostrander , MJ Botte , ME Brage . Efficacy of surgical preparation solutions in foot and ankle surgery. JBone Joint Surg Am 2005;87(5):980985.

36.PJ Culligan , K Kubik , M Murphy , L Blackwell , J Snyder . A randomized trial that compared povidone iodine and Chlorhexidine as antiseptics for vaginal hysterectomy. Am J Obstet Gynecol 2005;192(2):422425.

37.MD Saltzman , GW Nuber , SM Gryzlo , GS Marecek , JL Koh . Efficacy of surgical preparation solutions in shoulder surgery. J Bone Joint Surg Am 2009;91(8):19491953.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×