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Pseudo-Outbreak of Multidrug-Resistant Mycobacterium tuberculosis Associated With Presumed Laboratory Processing Contamination

  • Gonzalo Bearman (a1), Carlos Vaamonde (a1), Davise Larone (a2), Lewis Drusin (a1) and Gianna Zuccotti (a3)...

An investigation prompted by six positive cultures for multidrug-resistant Mycobacterium tuberculosis during a 7-week period found that an unusual resistance pattern, temporal proximity of laboratory processing, and identical DNA fingerprints supported the theory of cross-contamination. Laboratory processing procedures included specimen batching and multi-use vials of buffer solution. Processing procedures were changed and no additional cases of suspected cross-contamination have been observed. '(Infect Control Hosp Epidemiol 2002;23:622).

Corresponding author
Division of Infectious Disease, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 420, New York, NY 10021
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1. A Nitta , PT Davidson , ML de Koning , J Kilman . Misdiagnosis of multidrug resistant tuberculosis possibly due to laboratory errors. JAMA 1996;276:19801983.

3. VR Aber , BW Allen , DA Mitchison , P Ayuma , EA Edwards , AB Keyes . Quality control in tuberculosis bacteriology: I. Laboratory studies on isolated positive cultures and the efficacy of direct smear examination. Tubercle 1980;61:123133.

4. S Segal-Maurer , BN Kreisworth , JM Burns , et alMycobacterium tuberculosis specimen contamination revisited: the role of laboratory environmental control in a pseudo-outbreak. Infect Control Hosp Epidemiol 1998; 19:101105.

5. WJ Burman , RR Reves . Review of false-positive cultures for Mycobacterium tuberculosis and recommendations for avoiding unnecessary treatment. Clin Infect Dis 2000;31:13901395.

6. W Cronin , E Rodriguez , S Valway , et alPseudo-outbreak of tuberculosis in an acute care hospital: epidemiology and clinical implications. Infect Control Hosp Epidemiol 1998;19:345347.

7. JR Maurer , EP Desmond , MD Lesser , WD Jones Jr. False positive cultures of Mycobacterium-tuberculosis. Chest 1984;86:439443.

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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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