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A Randomized Controlled Trial of 1% Aqueous Chlorhexidine Gluconate Compared with 10% Povidone-Iodine for Topical Antiseptic in Neonates Effects on Blood Culture Contamination Rates

  • Pracha Nuntnarumit (a1) and Nartsiri Sangsuksawang (a1)

We conducted a randomized controlled trial in neonates with birth weight greater than or equal to 1,500 g that compared 1% aqueous chlorhexidine gluconate (CHG) with 10% povidone–iodine (PI) as a topical antiseptic. We found 1% CHG to be more effective than 1% PI in reducing blood culture contamination rates, and no contact dermatitis was observed.

Corresponding author
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 road, Bangkok, Thailand. 10400 (
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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