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Spread of Methicillin-Resistant Staphylococcus aureus (MRSA) Among Household Contacts of Individuals With Nosocomially Acquired MRSA

  • David P. Calfee (a1), Lisa J. Durbin (a1), Teresa P. Germanson (a2), Denise M. Toney (a3), Elise B. Smith (a3) and Barry M. Farr (a1)...
Abstract
AbstractObjective:

To determine the frequency with which methicillin-resistant Staphylococcus aureus (MRSA) is spread from colonized or infected patients to their household and community contacts.

Design:

Retrospective cohort study.

Setting:

University hospital.

Participants:

Household and community contacts of MRSA-colonized or -infected patients for whom MRSA screening cultures were performed.

Results:

MRSA was isolated from 25 (14.5%) of 172 individuals. Among the contacts of index patients who had at least one MRSA-colonized contact, those with close contact to the index patient were 7.5 times more likely to be colonized (53% vs 7%; 95% confidence interval, 1.1 to 50.3; P = .002). An analysis of antimicrobial susceptibility and DNA fingerprint patterns suggested person-to-person spread.

Conclusions:

MRSA colonization occurs frequently among household and community contacts of patients with nosocomially acquired MRSA, suggesting that transmission of nosocomially acquired MRSA outside of the healthcare setting may be a substantial source of MRSA colonization and infection in the community.

Copyright
Corresponding author
Box 801337, University of Virginia Health System, Charlottesville, VA 22908
References
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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