Skip to main content
    • Aa
    • Aa

Transient Detection of Plasma HIV-1 RNA During Postexposure Prophylaxis

  • Vincenzo Puro (a1), Giuseppe Calcagno (a2), Marco Anselmo (a2), Gisella Benvenuto (a2), Daria Trabattoni (a3), Mario Clerici (a3) and Giuseppe Ippolito (a1)...

Transient plasma human immunodeficiency virus (HIV) copies were detected by nucleic-acid sequence-based amplification during combination antiretroviral prophylaxis in a healthcare worker who reported a percutaneous injury from a stylet and who remained HIV-antibody-negative. An HIV-specific T-helper response, assessed by interleukin-2 production, was observed when tested at 13 months following the exposure.

Corresponding author
IRCCS “Lazzaro Spallanzani, ” Centro di Riferimento AIDS, Servizio di Epidemiologia delle Malattie Infettive, Via Portuense, 292-00149 Rome, Italy
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2. M Clerici , JM Levin , HA Kessler , A Harris , JA Berzofsky , AL Landay , et al. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. JAMA 1994;271:4246.

3. G Ippolito , V Puro , G De Carli . The risk of occupational HIV infection in health care workers. Italian Multicenter Study. The Italian Study Group on Occupational Risk of HIV Infection. Arch Intern Med 1993;153:14511458.

4. DM Cardo , DH Culver , CA Ciesielski , PU Srivastava , R Marcus , D Abiteboul , et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med 1997;337:14851490.

5. LA Pinto . AL Landay , JA Berzofsky , HA Kessler , GM Shearer . Immune response to human immunodeficiency virus (HIV) in healthcare workers occupationally exposed to HIV-contaminated blood. Am J Med 1997;102(5B):2124.

7. JD Rich , NA Merriman , E Mylonakis , TC Greenough , TP Flanigan , BJ Mady , et al. Misdiagnosis of HIV infection by HIV-1 plasma viral load testing: a case series. Ann Intern Med 1999;130:3739.

8. DH Schwartz , OB Laeyendecker , S Arango-Jaramillo , RC Castillo , MJ Reynolds . Extensive evaluation of a seronegative participant in an HIV-1 vaccine trial as a result of false positive PCR. Lancet 1997;350:256259.

9. C de Mendoza , A Holguin , V Soriano . False positive for HIV using commercial viral load quantification assays. AIDS 1998;12:20762077.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Altmetric attention score

Abstract views

Total abstract views: 25 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 24th July 2017. This data will be updated every 24 hours.