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    Pozzilli, Paolo Battelino, Tadej Danne, Thomas Hovorka, Roman Jarosz-Chobot, Przemyslawa and Renard, Eric 2016. Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics. Diabetes/Metabolism Research and Reviews, Vol. 32, Issue. 1, p. 21.

    Stadler, Marietta Zlamal-Fortunat, Sandra Schütz-Fuhrmann, Ingrid Rami-Merhar, Birgit Fröhlich-Reiterer, Elke Hofer, Sabine Mader, Julia Resl, Michael Kautzky-Willer, Alexandra Weitgasser, Raimund Prager, Rudolf and Bischof, Martin 2016. Insulinpumpentherapie bei Kindern, Jugendlichen und Erwachsenen. Wiener klinische Wochenschrift, Vol. 128, Issue. S2, p. 188.

    Brorsson, Anna Lena Viklund, Gunnel Örtqvist, Eva and Lindholm Olinder, Anna 2015. Does treatment with an insulin pump improve glycaemic control in children and adolescents with type 1 diabetes? A retrospective case-control study. Pediatric Diabetes, Vol. 16, Issue. 7, p. 546.

    Hannonen, Riitta Eklund, Kenneth Tolvanen, Asko Komulainen, Jorma Riikonen, Raili Delamater, Alan M. and Ahonen, Timo 2015. Psychological distress of children with early-onset type 1 diabetes and their mothers' well-being. Acta Paediatrica, Vol. 104, Issue. 11, p. 1144.

    Birkebaek, N.H. Kristensen, L.J. Mose, A.H. and Thastum, M. 2014. Quality of life in Danish children and adolescents with type 1 diabetes treated with continuous subcutaneous insulin infusion or multiple daily injections. Diabetes Research and Clinical Practice, Vol. 106, Issue. 3, p. 474.

  • International Journal of Technology Assessment in Health Care, Volume 29, Issue 1
  • January 2013, pp. 48-52


  • Andrea Lukács (a1), Emőke Kiss-Tóth (a1), Beatrix Varga (a2), Andrea Soós (a3), Peter Takác (a1) and László Barkai (a4)
  • DOI:
  • Published online: 28 December 2012

Purpose: The aim of this study was to compare the general health-related quality of life (HRQoL), the metabolic control (HbA1c), the anthropometric measurement, and the cardiorespiratory fitness (expressed by VO2max) in youths with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) to those receiving multiple daily injections (MDI). We looked for factors influencing the HRQoL and metabolic control.

Methods: A total of 239 patients treated with CSII (51 girls and 53 boys) or MDI (64 girls and 71 boys) between ages 8 and 18 years were assessed with the Pediatric Quality of Life Inventory, Generic Core Scales, and Diabetes Module. VO2max was evaluated using the 20-meter shuttle run test.

Results: CSII group had significantly better HRQoL according to both child self-report and parent proxy-report. Youths with CSII reported better physical, emotional, and school-related functioning, and had less diabetes-related fear and symptoms than the MDI group. There were no significant differences in body mass index z-scores, insulin doses, HbA1c, and VO2max between the groups. HRQoL was predicted by the CSII therapy (β = −0.220; p = .000) and the VO2max (β = 0.386; p = .000), other clinical and anthropometric parameters had no effect; the HbA1c was predicted only by VO2max (β = −0.353; p = .000).

Conclusions: Diabetic youths treated with CSII therapy have better HRQoL than those treated with MDI. There are no differences between the investigated groups in anthropometric data, glycated hemoglobin, and physical fitness. Moreover, good physical fitness has an important role in achieving better metabolic control and HRQoL, which underlines the importance of regular aerobic exercise in the treatment and care of type 1 diabetes in childhood.

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1.G Soltesz , CC Patterson , G Dahlquist ; (EURODIAB Study Group). Worldwide childhood type 1 diabetes incidence – what can we learn from epidemiology? Pediatr Diabetes. 2007;8 (Suppl 6):614.

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17.JW Varni , MA Burwinkle , JR Jacobs , et al.The PedsQL™ in type 1 and type 2 diabetes: reliability and validity of the Pediatric Quality of Life Inventory™ Generic Core Scales and type 1 Diabetes Module. Diabetes Care. 2003;26:631637.

18.LA Léger , D Mercier , C Gadoury , J Lambert . The multistage 20 metre shuttle run test for aerobic fitness. J Sports Sci. 1988;6:93101.

22.MJ Naughton , MS Ruggiero , JM Lawrence , et al.(SEARCH for Diabetes in Youth Study). Health-related quality of life of children and adolescents with type 1 or type 2 diabetes mellitus. Arch Pediatr Adolesc Med. 2008;162:649–57.

24.E Pańkowska , M Błazik , P Dziechciarz , A Szypowska , H Szajewska . Continuous subcutaneous insulin infusion vs. multiple daily injections in children with type 1 diabetes: a systematic review and meta-analysis of randomized control trials. Pediatr Diabetes. 2009;10:52–8.

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International Journal of Technology Assessment in Health Care
  • ISSN: 0266-4623
  • EISSN: 1471-6348
  • URL: /core/journals/international-journal-of-technology-assessment-in-health-care
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